Fmoc-cycloleucine
- CAS No.
- 117322-30-2
- Chemical Name:
- Fmoc-cycloleucine
- Synonyms
- Fmoc-cLeu-OH;FMOC-CLE-OH;FMOC-AC5C-OH;CAS:117322-30-2;FMOC-CYCLOLEUCINE;FMOC-NH(1)CPEN-OH;1-(Fmoc-amino)cycL;RARECHEM EM WB 0031;Fmoc-DL-cycloleucine;Fmoc-cycloleucine USP/EP/BP
- CBNumber:
- CB4329145
- Molecular Formula:
- C21H21NO4
- Molecular Weight:
- 351.4
- MDL Number:
- MFCD01074696
- MOL File:
- 117322-30-2.mol
- MSDS File:
- SDS
| Melting point | 187 °C(dec.) |
|---|---|
| Boiling point | 579.4±29.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | soluble in Dimethylformamide |
| form | powder to crystal |
| pka | 4.08±0.20(Predicted) |
| color | White to Light yellow |
| BRN | 5995036 |
| CAS DataBase Reference | 117322-30-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H402 |
| Precautionary statements | P273-P280-P305+P351+P338 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29242990 |
Fmoc-cycloleucine price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0866 | 1-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclopentanecarboxylic Acid >95.0%(HPLC)(T) | 117322-30-2 | 1g | $65 | 2026-04-30 | Buy |
| TCI Chemical | F0866 | 1-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclopentanecarboxylic Acid >95.0%(HPLC)(T) | 117322-30-2 | 5g | $224 | 2026-04-30 | Buy |
| Usbiological | 278069 | Fmoc-1-aminocyclopentane-1-carboxylic acid Asreported | 117322-30-2 | 1g | $349 | 2026-06-03 | Buy |
| Usbiological | 278069 | Fmoc-1-aminocyclopentane-1-carboxylic acid Asreported | 117322-30-2 | 2g | $482 | 2026-06-03 | Buy |
| Usbiological | 278069 | Fmoc-1-aminocyclopentane-1-carboxylic acid Asreported | 117322-30-2 | 5g | $844 | 2026-06-03 | Buy |
Fmoc-cycloleucine Chemical Properties,Uses,Production
Chemical Properties
White powder
Uses
Fmoc-cycloleucine is a reagent in the development of selective inhibitors of nuclear hormone receptors.
Synthesis
82911-69-1
52-52-8
117322-30-2
General procedure for the synthesis of Fmoc-cycloleucine from 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) and 1-aminocyclopentanecarboxylic acid: Fmoc-OSu (3.13 g, 9.3 mmol) was added to a mixture of acetonitrile/water (100 mL) and sodium bicarbonate (NaHCO3, 1.63 g, 1.4 mmol) containing 1-aminocyclopentanecarboxylic acid (1.0 g, 7.8 mmol) and sodium bicarbonate (NaHCO3, 1.63 g, 1.4 mmol). 19.4 mmol) in a mixed acetonitrile/water (100 mL, 1:1 v/v) solution. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, most of the solvent was removed by distillation under reduced pressure. Subsequently, the pH of the reaction mixture was adjusted to 2 with 2N hydrochloric acid (HCl) and extracted with dichloromethane (DCM). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4) and then concentrated. Finally, the residue was purified by silica gel fast column chromatography (petroleum ether/ethyl acetate=20:1) to afford the target product 1 -(((9H-fluoren-9-yl)methoxy)carbonylamino)cyclopentanecarboxylic acid (Compound 4 of Example A, 0.75 g, 28% yield) as a white solid.
References
[1] Journal of the American Chemical Society, 2000, vol. 122, # 37, p. 8898 - 8909
[2] Patent: WO2012/119941, 2012, A1. Location in patent: Page/Page column 110
[3] Journal of the American Chemical Society, 2003, vol. 125, # 23, p. 6852 - 6853
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 18, p. 5694 - 5706
Fmoc-cycloleucine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
View Lastest Price from Fmoc-cycloleucine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | N-Fmoc-1-amino-1-cyclopentanecarboxylic acid
117322-30-2
|
$1.10-9.90 | 1KG | 99%min | 100KG | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2020-01-01 | Fmoc-cycloleucine
117322-30-2
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- N-Fmoc-1-amino-1-cyclopentanecarboxylic acid
117322-30-2
- $1.10-9.90
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Fmoc-cycloleucine
117322-30-2
- $1.00
- 99%
- Career Henan Chemical Co
