MAREIN
- CAS No.
- 535-96-6
- Chemical Name:
- MAREIN
- Synonyms
- OKANIN-4'-O-GLUCOSIDE;MAREIN;MAREIN hplc;MAREIN WITH HPLC;Marein, 10 mM in DMSO;Okaini 4’-O-β-D-glucopyranoside;Okaini 4'-O-β-D-glucopyranoside;2',3,3',4,4'-PENTAHYDROXY-4'-GLUCOSYLCHALCONE;(E)-4'-(β-D-Glucopyranosyloxy)-2',3,3',4-tetrahydroxychalcone;(E)-3-(3,4-dihydroxyphenyl)-1-[4-(?-D-glucopyranosyloxy)-2,3-dihydroxyphenyl]-2-propen-1-one
- CBNumber:
- CB4330620
- Molecular Formula:
- C21H22O11
- Molecular Weight:
- 450.39
- MDL Number:
- MFCD00017496
- MOL File:
- 535-96-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 197-202°C |
|---|---|
| Boiling point | 835.4±65.0 °C(Predicted) |
| Density | 1.664±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | DMSO: soluble |
| form | A crystalline solid |
| pka | 6.92±0.40(Predicted) |
| color | Light yellow to yellow |
| InChIKey | XGEYXJDOVMEJNG-UOWIVAOKNA-N |
| SMILES | [C@@H]1([C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)OC1C=CC(C(=O)/C=C/C2C=CC(O)=C(O)C=2)=C(O)C=1O |&1:0,1,3,4,6,r| |
| LogP | -0.180 (est) |
| FDA UNII | CY787E65J4 |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi |
|---|
MAREIN price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 33213 | Marein ≥95% | 535-96-6 | 1mg | $53 | 2026-04-30 | Buy |
| Cayman Chemical | 33213 | Marein ≥95% | 535-96-6 | 5mg | $212 | 2026-04-30 | Buy |
| Cayman Chemical | 33213 | Marein ≥95% | 535-96-6 | 10mg | $344 | 2026-04-30 | Buy |
| Cayman Chemical | 33213 | Marein ≥95% | 535-96-6 | 25mg | $594 | 2026-04-30 | Buy |
| Usbiological | 380779 | Marein ≥98% | 535-96-6 | 10mg | $585 | 2026-06-03 | Buy |
MAREIN Chemical Properties, Uses, Production
Uses
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects[1][2][3].
Definition
ChEBI: Marein is a member of flavonoids and a glycoside.
References
[1] B Orlikova, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805. DOI:10.3892/or.2012.1870
[2] Baoping Jiang, et al. Protective effects of marein on high glucose-induced glucose metabolic disorder in HepG2 cells. Phytomedicine. 2016 Aug 15;23(9):891-900. DOI:10.1016/j.phymed.2016.05.004
[3] Baoping Jiang, et al. Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells. Free Radic Res. 2016;50(11):1173-1187. DOI:10.1080/10715762.2016.1222374
MAREIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Yongjian Pharmaceutical Technology Co., Ltd | 17701422015 | 3582572959@qq.com | China | 990 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | synchempharma@aliyun.com | China | 4988 | 55 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7982 | 55 |
