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ChemicalBook >> CAS DataBase List >>1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)-

1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)-

1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- Structure
1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- structure
CAS No.
136564-67-5
Chemical Name:
1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)-
Synonyms
LTD4 antagonist 1;LTD4 antagonist 1,LTD-4 antagonist 1;1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)-
CBNumber:
CB43339552
Molecular Formula:
C31H32F3N3O5S
Molecular Weight:
615.6630896
MDL Number:
MFCD31544443
MOL File:
136564-67-5.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24
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1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- Properties

storage temp. Store at -20°C
solubility Soluble in DMSO

1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- Chemical Properties, Uses, Production

Uses

LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.

in vivo

LTD4 antagonist 1 (Compound 38b) exhibits a po ED50/iv ED50 of 1.44 and 0.036 μmol/kg in LTD4-induced bronchoconstriction in guinea pigs[1].

IC 50

LTD4: 0.57 nM (Ki)

References

[1] Robert T. Jacobs, et al. Synthesis, Structure-Activity Relationships, and Pharmacological Evaluation of a Series of Fluorinated 3-Benzyl-5-Indolecarboxamides: Identification of 4-[[5-[((2R)-2-Methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methylindol-3-yl]meth

1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- Suppliers

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BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
BOC Sciences 65
MedChemexpress LLC 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58
1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- LTD4 antagonist 1 LTD4 antagonist 1,LTD-4 antagonist 1 136564-67-5