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N,N'-Bis-Z-1-guanylpyrazole

N,N'-Bis-Z-1-guanylpyrazole Structure
N,N'-Bis-Z-1-guanylpyrazole structure
CAS No.
152120-55-3
Chemical Name:
N,N'-Bis-Z-1-guanylpyrazole
Synonyms
Z-Pyrazol;Pyrazol(Z)2;PYRAZOLE(Z)2;Pyrazol(Z)2≥ 99% (HPLC);N,N'-Bis-Z-1-guanylpyrazole;N,N'-Bis-Z-1-guanylpyrazole;N,N'-Di-Cbz-1H-pyrazole-1-carbo;1-[N,N'-(Di-Cbz)amidino]pyrazole;N,N'-DI-Z-1H-PYRAZOL-1-CARBAMIDINE;N,N'-DI-Z-1H-PYRAZOLE-1-CARBAMIDINE
CBNumber:
CB4334204
Molecular Formula:
C20H18N4O4
Molecular Weight:
378.39
MDL Number:
MFCD02092983
MOL File:
152120-55-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:45
Request For Quotation

N,N'-Bis-Z-1-guanylpyrazole Properties

Melting point 90-96 °C
Density 1.25±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form powder to crystal
pka 6.66±0.46(Predicted)
color White to Almost white
Major Application peptide synthesis
InChI InChI=1S/C20H18N4O4/c25-19(27-14-16-8-3-1-4-9-16)22-18(24-13-7-12-21-24)23-20(26)28-15-17-10-5-2-6-11-17/h1-13H,14-15H2,(H,22,23,25,26)
InChIKey NRBUVVTTYMTSKM-UHFFFAOYSA-N
SMILES C(/N1N=CC=C1)(\NC(=O)OCC1C=CC=CC=1)=N\C(=O)OCC1C=CC=CC=1
UNSPSC Code 12352200
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
F  10-21
HS Code  29331990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

N,N'-Bis-Z-1-guanylpyrazole price More Price(88)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 439428 N,N′-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine 97% 152120-55-3 5g $236 2026-04-30 Buy
TCI Chemical B3605 N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine >98.0%(HPLC)(T) 152120-55-3 1g $60 2026-04-30 Buy
TCI Chemical B3605 N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine >98.0%(HPLC)(T) 152120-55-3 5g $178 2026-04-30 Buy
Usbiological 264288 N,N'-Bis-Z-1-guanylpyrazole Asreported 152120-55-3 5g $429 2026-06-03 Buy
Usbiological 264288 N,N'-Bis-Z-1-guanylpyrazole Asreported 152120-55-3 10g $656 2026-06-03 Buy
Product number Packaging Price Buy
439428 5g $236 Buy
B3605 1g $60 Buy
B3605 5g $178 Buy
264288 5g $429 Buy
264288 10g $656 Buy

N,N'-Bis-Z-1-guanylpyrazole Chemical Properties, Uses, Production

Chemical Properties

Off-white powder

Uses

N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine is used as pharmaceutical intermediate.

Synthesis

N-Z-1H-PYRAZOLE-1-CARBOXAMIDINE

152120-62-2

Benzyl chloroformate

501-53-1

N,N'-BIS-Z-1-GUANYLPYRAZOLE

152120-55-3

Step 2 Synthesis of N,N'-bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine: N-(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine (58.62 g, 239 mmol) was dissolved in 600 mL of anhydrous THF, and the reaction mixture was cooled to 0 °C and stirred under nitrogen atmosphere. 60% NaH (28.8 g) was added to the reaction mixture in batches and the reaction temperature was maintained at 0 °C. Subsequently, 60 mL of anhydrous THF solution of benzyl chloroformate (40.9 mL) was added dropwise over 30 minutes. The reaction mixture was continued to be stirred at 0 °C for 2 hours and then brought to room temperature and stirred for 18 hours. The reaction mixture was again cooled to 0 °C and saturated aqueous Na2SO4 solution was slowly added to quench the reaction. The reaction mixture was diluted with EtOAc and filtered through diatomaceous earth. The organic layer was dried with MgSO4, filtered and concentrated under reduced pressure to give a viscous oil. After washing with hexane and drying under reduced pressure, N,N'-bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine was obtained as 67.81 g in 75% yield.

References

[1] Patent: US2008/207655, 2008, A1. Location in patent: Page/Page column 17

N,N'-Bis-Z-1-guanylpyrazole Preparation Products And Raw materials

Raw materials

N-Z-1H-pyrazole-1-carboxamidine Benzyl chloroformate Sodium hydride Tetrahydrofuran

Preparation Products

N,N'-Bis-Z-1-guanylpyrazole Suppliers

Global Suppliers ( 147)
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 1846 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Supplier Advantage
Suzhou Highfine Biotech Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62

View Latest Price from N,N'-Bis-Z-1-guanylpyrazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N,N'-BIS-Z-1-GUANYLPYRAZOLE pictures 2025-04-04 N,N'-BIS-Z-1-GUANYLPYRAZOLE
152120-55-3
 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
N,N 2021-07-13 N,N"-BIS-Z-1-GUANYLPYRAZOLE
152120-55-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
N,N 2021-07-09 N,N"-BIS-Z-1-GUANYLPYRAZOLE
152120-55-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

N,N'-Bis-Z-1-guanylpyrazole Spectrum

N,N'-BIS-Z-1-GUANYLPYRAZOLE(152120-55-3)1HNMR

152120-55-3 (N,N'-Bis-Z-1-guanylpyrazole) Related Search:

Aminoguanidine Sulfate N,N'-Bis-Z-1-guanylpyrazole N-Z-1H-pyrazole-1-carboxamidine N,N'-Bis-Boc-1-guanylpyrazole 10-Oxa-2,4,8-triazadodec-2-enoic acid, 4-[(1,1-dimethylethoxy)carbonyl]-11,11-dimethyl-9-oxo-3-(1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester
Carbamic acid, N-[[[(1,1-dimethylethoxy)carbonyl]amino]-1H-pyrazol-1-ylmethylene]-, 1,1-dimethylethyl ester, [N(E)]-

1of2

Benzyl ((((benzyloxy)carbonyl)aMino)(1H-pyrazol-1-yl)Methylene)carbaMate Pyrazol(Z)2≥ 99% (HPLC) Pyrazol(Z)2N,N'-Di-Cbz-1H-pyrazole-1-carbaMidine N,N'-Di-Cbz-1H-pyrazole-1-carboxamidine -Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine N-[phenylmethoxycarbonylamino(1-pyrazolyl)methylidene]carbamic acid (phenylmethyl) ester N,N'-DI-Z-1H-PYRAZOLE-1-CARBAMIDINE N,N-BIS(BENZYLOXYCARBONYL)-1H-PYRAZOLE-1 N,N-Bisbenzyloxycarbonyl-1-guanylpyrazole, N,N-Di-Cbz-1H-pyrazole-1-carboxamidine Pyrazol(Z)2 PYRAZOLE(Z)2 N,N'-DI-Z-1H-PYRAZOL-1-CARBAMIDINE N,N-BISBENZYLOXYCARBONYL-1-GUANYLPYRAZOLE N,N'-Di-Cbz-1H-pyrazole-1-carbamidine N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine N,N'Bis(Bezyloxycarbonyl)1H-pyrazole1carboxaMidine N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxaM Pyrazol(Z)2 N,N'-Bis-Z-1-Guanylpyrazole N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxaMidine, 98+% N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine N,N'-Di-Cbz-1H-pyrazole-1-carboxamidine N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine > benzyl (NZ)-N-[phenylmethoxycarbonylamino(pyrazol-1-yl)methylidene]carbamate Carbamic acid, N-[[[(phenylmethoxy)carbonyl]amino]-1H-pyrazol-1-ylmethylene]-, phenylmethyl ester (Z)-Benzyl(1H-pyrazol-1-yl)methylenedicarbamate 1-[N,N'-(Di-Cbz)amidino]pyrazole 1-[N,N'-Bis(carbobenzoxy)amidino]pyrazole N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboximidamide N,N'-Di-Cbz-1H-pyrazole-1-carbo benzyl (NZ)-N-[benzyloxycarbonylamino(pyrazol-1-yl)methylene]carbamate Pyrazol(Z)2 N,N'-Bis-Z-1-Guanylpyrazole N,N'-Di-Cbz-pyrazole-1-carboxamidine N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine N,N′-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine N,N′-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine, CAS 152120-55-3 Z-Pyrazol N,N'-Bis-Z-1-guanylpyrazole N,N'-Bis-Z-1-guanylpyrazole 152120-55-3 Guanidine Protection/Guanidinylation Peptide Synthesis Specialty Synthesis Guanidine Protection/Guanidinylation Peptide Synthesis Specialty Synthesis