SCH-351591
- CAS No.
- 444659-43-2
- Chemical Name:
- SCH-351591
- Synonyms
- D4396;D-4396;D 4396;SCH-351591;5-Quinolinecarboxamide, N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-
- CBNumber:
- CB43352155
- Molecular Formula:
- C17H10Cl2F3N3O3
- Molecular Weight:
- 432.18
- MDL Number:
- MOL File:
- 444659-43-2.mol
- MSDS File:
- SDS
| Boiling point | 530.8±50.0 °C(Predicted) |
|---|---|
| Density | 1.57±0.1 g/cm3(Predicted) |
| pka | 8.17±0.70(Predicted) |
| FDA UNII | G6EF7V146S |
SCH-351591 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0015494 | SCH 351591 99.22% | 444659-43-2 | 5mg | $552 | 2026-06-04 | Buy |
| ChemScene | CS-0015494 | SCH 351591 99.22% | 444659-43-2 | 10mg | $884 | 2026-06-04 | Buy |
| ChemScene | CS-0015494 | SCH 351591 99.22% | 444659-43-2 | 25mg | $1768 | 2026-06-04 | Buy |
| ChemScene | CS-0015494 | SCH 351591 99.22% | 444659-43-2 | 50mg | $2830 | 2026-06-04 | Buy |
| ChemScene | CS-0015494 | SCH 351591 99.22% | 444659-43-2 | 100mg | $4528 | 2026-06-04 | Buy |
SCH-351591 Chemical Properties, Uses, Production
Uses
SCH 351591 is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 58 nM. SCH 351591 can inhibit all 4 PDE4 subtypes (A, B, C, and D). SCH 351591 has the potential for the asthma and chronic obstructive pulmonary disease (COPD) research[1].
Definition
ChEBI: SCH-351591 is an aromatic amide resulting from the formal condensation of the carboxy group of 8-methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid with the primary amino group of 3,5-dichloropyridin-4-amine 1-oxide. It is a potent inhibitor of phosphodiesterase IV (PDE4). It has a role as a phosphodiesterase IV inhibitor. It is a member of pyridine N-oxides, a chloropyridine, a monocarboxylic acid amide, a member of quinolines, an aromatic ether, an aromatic amide and an organofluorine compound.
IC 50
PDE4: 58 nM (IC50)
References
[1] Patricia E Losco, et al. The toxicity of SCH 351591, a novel phosphodiesterase-4 inhibitor, in Cynomolgus monkeys. Toxicol Pathol. 2004 May-Jun;32(3):295-308. DOI:10.1080/01926230490431493
SCH-351591 Preparation Products And Raw materials
Raw materials
Preparation Products
SCH-351591 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20027 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 10000 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from SCH-351591 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-21 | SCH-351591
444659-43-2
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- SCH-351591
444659-43-2
- $1520.00-2500.00
- TargetMol Chemicals Inc.
