2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
- CAS No.
- 32675-71-1
- Chemical Name:
- 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
- Synonyms
- (Rac)-RG108;2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
- CBNumber:
- CB43372267
- Molecular Formula:
- C19H14N2O4
- Molecular Weight:
- 334.33
- MDL Number:
- MOL File:
- 32675-71-1.mol
- MSDS File:
- SDS
| Boiling point | 606.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.502±0.06 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility |
DMSO: 100mg/mL methanol: soluble |
| form | Yellow solid |
| pka | 3.62±0.10(Predicted) |
| color | yellow |
| InChI | 1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25) |
| InChIKey | HPTXLHAHLXOAKV-UHFFFAOYSA-N |
| SMILES | [nH]1c2c(c(c1)CC(N3C(=O)c4c(cccc4)C3=O)C(=O)O)cccc2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.54 |
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 260920 | DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem | 32675-71-1 | 10mg | $229 | 2026-04-30 | Buy |
| Biosynth | HBA67571 | DNA methyltransferase inhibitor | 32675-71-1 | 50mg | $1305 | 2026-06-04 | Buy |
| Biosynth | HBA67571 | DNA methyltransferase inhibitor | 32675-71-1 | 0.5g | $1480.9 | 2026-06-04 | Buy |
| ChemScene | CS-0137819 | (Rac)-RG108 98% | 32675-71-1 | 5mg | $325 | 2026-06-04 | Buy |
| ChemScene | CS-0137819 | (Rac)-RG108 98% | 32675-71-1 | 10mg | $520 | 2026-06-04 | Buy |
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Chemical Properties, Uses, Production
Uses
A cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.
General Description
A cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.
Biochem/physiol Actions
Cell permeable: yes
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Zhengzhou Ruike Biochemical Technology Co., Ltd. | 18521304688;17324816296 | 421551521@qq.com | China | 280 | 58 |
| Changzhou Xianglong Pharmaceutical Technology Co., LTD | 18661161657 | sales@xianglongpharm.com | China | 9998 | 58 |
| Tan-Mo Technology Co., Ltd. | 19850211281 | qiann@gbw-china.com | China | 1973 | 58 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
