PD 404182
- CAS No.
- 72596-74-8
- Chemical Name:
- PD 404182
- Synonyms
- PD 404,182;3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;2H,6H-Pyrimido[1,2-c][1,3]benzothiazin-6-imine, 3,4-dihydro-;3，4-Dihydro-2H，6H-benzo[e]pyrimido[1，2-c][1，3]thiazin-6-imine;6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
- CBNumber:
- CB4347334
- Molecular Formula:
- C11H11N3S
- Molecular Weight:
- 217.29
- MDL Number:
- MFCD03788000
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 366.8±25.0 °C(Predicted) |
|---|---|
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥22 mg/mL, soluble |
| pka | 6.27±0.20(Predicted) |
| form | powder |
| color | Light yellow to yellow |
| FDA UNII | 3PYK7K517E |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
PD 404182 price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 34396 | PD 404182 ≥98% | 72596-74-8 | 5mg | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 34396 | PD 404182 ≥98% | 72596-74-8 | 10mg | $183 | 2026-04-30 | Buy |
| Cayman Chemical | 34396 | PD 404182 ≥98% | 72596-74-8 | 25mg | $402 | 2026-04-30 | Buy |
| Cayman Chemical | 34396 | PD 404182 ≥98% | 72596-74-8 | 50mg | $702 | 2026-04-30 | Buy |
| Biosynth | XCA59674 | 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine | 72596-74-8 | 25mg | $1237.25 | 2026-06-05 | Buy |
PD 404182 Chemical Properties,Uses,Production
Uses
PD 404182 is an inhibitor of SARS-CoV-2
Enzyme inhibitor
This KDO-8-P synthase inhibitor and potential antibiotic (FW = 217.29 g/mol), also named 6H-6-imino(2,3,4,5-tetrahydropyrimido)[1,2-c][1,3] benzothiazine, is a slow, tight-binding agent that targets 3-deoxy-D-mannooctulosonate-8-phosphate synthase, an enzyme participating in the synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO). The latter is an essential component of LPS (lipopolysaccharide) in the outer membrane of Gramnegative bacteria. PD 404182 is an antiretroviral agent with submicromolarinhibitory activity against human immunodeficiency virus-1 (HIV-1) and HIV-2 infection. PD-404182 also potently inhibits dimethylarginine dimethylaminohydrolase isoform-1 (DDAH1), the human enzyme that degrades Asymmetric Dimethylarginine, or ADMA (See Asymmetric Dimethylarginine). Because ADMA inhibits nitric oxide synthesis and because ADMA levels are predictive for future cardiovascular disease, chronic use of PD-404182 is apt to have side-effects.
PD 404182 Preparation Products And Raw materials
Raw materials
Preparation Products
PD 404182 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4905 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9796 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| DC Chemicals | 021-58447131 13564518121 | doncunbiosci@gmail.com | China | 618 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
