N-Methyl-N-(trimethylsilyl)acetamide
- CAS No.
- 7449-74-3
- Chemical Name:
- N-Methyl-N-(trimethylsilyl)acetamide
- Synonyms
- N-METHYL-N-TRIMETHYLSILYLACETAMIDE;MOUSE ALBUMIN;N-Methyl-N-TMS-acetamide;[TriMethylsilylating Agent];N-Methyl-N-(trimethylsilyl)amide;N-METHYL-N-TRIMETHYLSILYACETAMIDE;N-Methyl-N-trimethylsilylacetamine;N-TRIMETHYLSILYL-N-METHYLACETAMIDE;n-methyl-n-(trimethylsilyl)-acetamid;Acetamide,N-methyl-N-(trimethylsilyl)-
- CBNumber:
- CB4355232
- Molecular Formula:
- C6H15NOSi
- Molecular Weight:
- 145.27
- MDL Number:
- MFCD00040758
- MOL File:
- 7449-74-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 159-161 °C(lit.) |
|---|---|
| Density | 0.904 g/mL at 20 °C(lit.) |
| refractive index |
n |
| Flash point | 48 °C |
| storage temp. | -20°C |
| form | lyophilized powder |
| pka | -0.11±0.70(Predicted) |
| color | Clear light yellow |
| Specific Gravity | 0.906 |
| Sensitive | Moisture Sensitive |
| BRN | 506975 |
| InChI | InChI=1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3 |
| InChIKey | QHUOBLDKFGCVCG-UHFFFAOYSA-N |
| SMILES | C(N(C)[Si](C)(C)C)(=O)C |
| CAS DataBase Reference | 7449-74-3(CAS DataBase Reference) |
| FDA UNII | W0IWF6UKW5 |
| NIST Chemistry Reference | Acetamide, n-methyl-n-(trimethylsilyl)-(7449-74-3) |
| EPA Substance Registry System | Acetamide, N-methyl-N-(trimethylsilyl)- (7449-74-3) |
| UNSPSC Code | 12000000 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H314-H315-H319-H335-H226 | |||||||||
| Precautionary statements | P261-P303+P361+P353-P305+P351+P338-P501a-P210-P233-P240-P241+P242+P243-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P370+P378-P403+P235-P405-P501 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 37/39-16 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Flam. Liq. 3 | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
N-Methyl-N-(trimethylsilyl)acetamide price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 69480 | N-Methyl-N-trimethylsilylacetamide for GC derivatization, ≥97.0% (GC) | 7449-74-3 | 10ml | $189 | 2022-05-15 | Buy |
| TCI Chemical | M0536 | N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] >95.0%(GC) | 7449-74-3 | 10g | $92 | 2026-04-30 | Buy |
| TCI Chemical | M0536 | N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] >95.0%(GC) | 7449-74-3 | 25g | $179 | 2026-04-30 | Buy |
| TRC | TRC-M321985-5G | N-Methyl-N-trimethylsilylacetamide | 7449-74-3 | 5g | $96 | 2026-06-03 | Buy |
| TRC | TRC-M321985-1G | N-Methyl-N-trimethylsilylacetamide | 7449-74-3 | 1g | $65 | 2026-06-03 | Buy |
N-Methyl-N-(trimethylsilyl)acetamide Chemical Properties, Uses, Production
Chemical Properties
clear light yellow liquid
Uses
N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:
- Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.
- Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.
Reactions
The interaction of N-Methyl-N-(trimethylsilyl)acetamide with chloromethyl(methyl)-diacetoxysilane led to the formation of 2,4,6-trimethyl-2,4-bis((N-methylacetamido)methyl)-1,3,5,2,4-trioxadisilinan-6-ylium chloride[1].
General Description
N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).
reaction suitability
reagent type: derivatization reagent
reaction type: Silylations
Purification Methods
N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]
References
[1] Nataliya F. Lazareva, Igor M.Lazarev,lrina V.Sterkhova. "Trans-silylationof N-methyl-N-trimethylsilylacetamide with chloromethyl(methyl)diacetoxysilane."Journal of Organometallic Chemistry1006 (2023): Article 123000.
N-Methyl-N-(trimethylsilyl)acetamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44567 | 61 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
View Latest Price from N-Methyl-N-(trimethylsilyl)acetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | N-Methyl-N-(trimethylsilyl)acetamide
7449-74-3
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2026-06-30 | N-Methyl-N-(trimethylsilyl)acetamide
7449-74-3
|
1KG | 90.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2021-07-13 | N-Methyl-N-trimethylsilylacetamide
7449-74-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- N-Methyl-N-(trimethylsilyl)acetamide
7449-74-3
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- N-Methyl-N-(trimethylsilyl)acetamide
7449-74-3
- 90.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- N-Methyl-N-trimethylsilylacetamide
7449-74-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
