N-Methyl-N-(trimethylsilyl)acetamide
- CAS No.
- 7449-74-3
- Chemical Name:
- N-Methyl-N-(trimethylsilyl)acetamide
- Synonyms
- N-METHYL-N-TRIMETHYLSILYLACETAMIDE;MOUSE ALBUMIN;N-Methyl-N-TMS-acetamide;[TriMethylsilylating Agent];N-Methyl-N-(trimethylsilyl)amide;N-METHYL-N-TRIMETHYLSILYACETAMIDE;N-Methyl-N-trimethylsilylacetamine;N-TRIMETHYLSILYL-N-METHYLACETAMIDE;n-methyl-n-(trimethylsilyl)-acetamid;Acetamide,N-methyl-N-(trimethylsilyl)-
- CBNumber:
- CB4355232
- Molecular Formula:
- C6H15NOSi
- Molecular Weight:
- 145.27
- MDL Number:
- MFCD00040758
- MOL File:
- 7449-74-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| N-Methyl-N-trimethylsilylacetamide for GC derivatization, ≥97.0% (GC) | 69480 | 10ml | $189 |
| N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] >95.0%(GC) | M0536 | 10g | $92 |
| N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] >95.0%(GC) | M0536 | 25g | $179 |
| N-Methyl-N-trimethylsilylacetamide | M321985 | 10g | $105 |
| N-Methyl-N-trimethylsilylacetamide | M321985 | 5g | $70 |
| More product size | |||
| Boiling point | 159-161 °C(lit.) |
|---|---|
| Density | 0.904 g/mL at 20 °C(lit.) |
| refractive index |
n |
| Flash point | 48 °C |
| storage temp. | -20°C |
| form | lyophilized powder |
| pka | -0.11±0.70(Predicted) |
| color | Clear light yellow |
| Specific Gravity | 0.906 |
| Sensitive | Moisture Sensitive |
| BRN | 506975 |
| InChI | InChI=1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3 |
| InChIKey | QHUOBLDKFGCVCG-UHFFFAOYSA-N |
| SMILES | C(N(C)[Si](C)(C)C)(=O)C |
| CAS DataBase Reference | 7449-74-3(CAS DataBase Reference) |
| FDA UNII | W0IWF6UKW5 |
| NIST Chemistry Reference | Acetamide, n-methyl-n-(trimethylsilyl)-(7449-74-3) |
| EPA Substance Registry System | Acetamide, N-methyl-N-(trimethylsilyl)- (7449-74-3) |
| UNSPSC Code | 12000000 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H314-H315-H319-H335-H226 | |||||||||
| Precautionary statements | P261-P303+P361+P353-P305+P351+P338-P501a-P210-P233-P240-P241+P242+P243-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P370+P378-P403+P235-P405-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 37/39-16 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
N-Methyl-N-(trimethylsilyl)acetamide price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 69480 | N-Methyl-N-trimethylsilylacetamide for GC derivatization, ≥97.0% (GC) | 7449-74-3 | 10ml | $189 | 2022-05-15 | Buy |
| TCI Chemical | M0536 | N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] >95.0%(GC) | 7449-74-3 | 10g | $92 | 2025-07-31 | Buy |
| TCI Chemical | M0536 | N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] >95.0%(GC) | 7449-74-3 | 25g | $179 | 2025-07-31 | Buy |
| TRC | M321985 | N-Methyl-N-trimethylsilylacetamide | 7449-74-3 | 10g | $105 | 2021-12-16 | Buy |
| TRC | M321985 | N-Methyl-N-trimethylsilylacetamide | 7449-74-3 | 5g | $70 | 2021-12-16 | Buy |
N-Methyl-N-(trimethylsilyl)acetamide Chemical Properties,Uses,Production
Chemical Properties
clear light yellow liquid
Uses
N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:
- Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.
- Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.
Reactions
The interaction of N-Methyl-N-(trimethylsilyl)acetamide with chloromethyl(methyl)-diacetoxysilane led to the formation of 2,4,6-trimethyl-2,4-bis((N-methylacetamido)methyl)-1,3,5,2,4-trioxadisilinan-6-ylium chloride[1].
General Description
N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).
reaction suitability
reagent type: derivatization reagent
reaction type: Silylations
Purification Methods
N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]
References
[1] Nataliya F. Lazareva, Igor M.Lazarev,lrina V.Sterkhova. "Trans-silylationof N-methyl-N-trimethylsilylacetamide with chloromethyl(methyl)diacetoxysilane."Journal of Organometallic Chemistry1006 (2023): Article 123000.
N-Methyl-N-(trimethylsilyl)acetamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13588 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29796 | 58 |
| Hubei Co-Formula Material Tech Co., Ltd. | +86-27-84459282 | sales@cfmats.com | CHINA | 882 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9208 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
View Lastest Price from N-Methyl-N-(trimethylsilyl)acetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-01 | N-Methyl-N-(trimethylsilyl)acetamide
7449-74-3
|
US $0.00-0.00 / KG | 1KG | 90.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-10-13 | N-Methyl-N-(trimethylsilyl)acetamide
7449-74-3
|
US $3.00-9.00 / KG | 0.1KG | 99% | g-kg-tons, free sample is available | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2021-07-13 | N-Methyl-N-trimethylsilylacetamide
7449-74-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- N-Methyl-N-(trimethylsilyl)acetamide
7449-74-3
- US $0.00-0.00 / KG
- 90.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- N-Methyl-N-(trimethylsilyl)acetamide
7449-74-3
- US $3.00-9.00 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- N-Methyl-N-trimethylsilylacetamide
7449-74-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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