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N-Methyl-N-(trimethylsilyl)acetamide

N-Methyl-N-(trimethylsilyl)acetamide Structure
N-Methyl-N-(trimethylsilyl)acetamide structure
CAS No.
7449-74-3
Chemical Name:
N-Methyl-N-(trimethylsilyl)acetamide
Synonyms
N-METHYL-N-TRIMETHYLSILYLACETAMIDE;MOUSE ALBUMIN;N-Methyl-N-TMS-acetamide;[TriMethylsilylating Agent];N-Methyl-N-(trimethylsilyl)amide;N-METHYL-N-TRIMETHYLSILYACETAMIDE;N-Methyl-N-trimethylsilylacetamine;N-TRIMETHYLSILYL-N-METHYLACETAMIDE;n-methyl-n-(trimethylsilyl)-acetamid;Acetamide,N-methyl-N-(trimethylsilyl)-
CBNumber:
CB4355232
Molecular Formula:
C6H15NOSi
Molecular Weight:
145.27
MDL Number:
MFCD00040758
MOL File:
7449-74-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:58:06
Product description Number Pack Size Price
N-Methyl-N-trimethylsilylacetamide for GC derivatization, ≥97.0% (GC) 69480 10ml $189
N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] >95.0%(GC) M0536 10g $92
N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] >95.0%(GC) M0536 25g $179
N-Methyl-N-trimethylsilylacetamide TRC-M321985-5G 5g $96
N-Methyl-N-trimethylsilylacetamide TRC-M321985-1G 1g $65
More product size
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N-Methyl-N-(trimethylsilyl)acetamide Properties

Boiling point 159-161 °C(lit.)
Density 0.904 g/mL at 20 °C(lit.)
refractive index n20/D 1.439
Flash point 48 °C
storage temp. -20°C
form lyophilized powder
pka -0.11±0.70(Predicted)
color Clear light yellow
Specific Gravity 0.906
Sensitive Moisture Sensitive
BRN 506975
InChI InChI=1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3
InChIKey QHUOBLDKFGCVCG-UHFFFAOYSA-N
SMILES C(N(C)[Si](C)(C)C)(=O)C
CAS DataBase Reference 7449-74-3(CAS DataBase Reference)
FDA UNII W0IWF6UKW5
NIST Chemistry Reference Acetamide, n-methyl-n-(trimethylsilyl)-(7449-74-3)
EPA Substance Registry System Acetamide, N-methyl-N-(trimethylsilyl)- (7449-74-3)
UNSPSC Code 12000000
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Flame (GHS02)Exclamation Mark (GHS07)
GHS05,GHS02,GHS07
Signal word  Warning
Hazard statements  H314-H315-H319-H335-H226
Precautionary statements  P261-P303+P361+P353-P305+P351+P338-P501a-P210-P233-P240-P241+P242+P243-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P370+P378-P403+P235-P405-P501
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  10-36/37/38
Safety Statements  37/39-16
RIDADR  UN 1993 3/PG 3
WGK Germany  3
F  10-21
TSCA  TSCA listed
HazardClass  3
PackingGroup  III
HS Code  29319090
Storage Class 3 - Flammable liquids
Hazard Classifications Flam. Liq. 3
REACH Registrations Active
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

N-Methyl-N-(trimethylsilyl)acetamide price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 69480 N-Methyl-N-trimethylsilylacetamide for GC derivatization, ≥97.0% (GC) 7449-74-3 10ml $189 2022-05-15 Buy
TCI Chemical M0536 N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] >95.0%(GC) 7449-74-3 10g $92 2026-04-30 Buy
TCI Chemical M0536 N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] >95.0%(GC) 7449-74-3 25g $179 2026-04-30 Buy
TRC TRC-M321985-5G N-Methyl-N-trimethylsilylacetamide 7449-74-3 5g $96 2026-06-03 Buy
TRC TRC-M321985-1G N-Methyl-N-trimethylsilylacetamide 7449-74-3 1g $65 2026-06-03 Buy
Product number Packaging Price Buy
69480 10ml $189 Buy
M0536 10g $92 Buy
M0536 25g $179 Buy
TRC-M321985-5G 5g $96 Buy
TRC-M321985-1G 1g $65 Buy

N-Methyl-N-(trimethylsilyl)acetamide Chemical Properties,Uses,Production

Chemical Properties

clear light yellow liquid

Uses

N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:

  • Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.
  • Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

Reactions

The interaction of N-Methyl-N-(trimethylsilyl)acetamide with chloromethyl(methyl)-diacetoxysilane led to the formation of 2,4,6-trimethyl-2,4-bis((N-methylacetamido)methyl)-1,3,5,2,4-trioxadisilinan-6-ylium chloride[1].
N-Methyl-N-(trimethylsilyl)acetamide

General Description

N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

Purification Methods

N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]

References

[1] Nataliya F. Lazareva, Igor M.Lazarev,lrina V.Sterkhova. "Trans-silylationof N-methyl-N-trimethylsilylacetamide with chloromethyl(methyl)diacetoxysilane."Journal of Organometallic Chemistry1006 (2023): Article 123000.

N-Methyl-N-(trimethylsilyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-N-ethylacetamide

N-Methyl-N-(trimethylsilyl)acetamide Suppliers

Global( 166)Suppliers
Supplier Tel Email Country ProdList Advantage
Alfa Chemistry
+1-5166625404; Info@alfa-chemistry.com United States 20405 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-15225627621 +86-13213167925 jiuyitime@fdachem.com China 16512 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14014 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Hubei Co-Formula Material Tech Co., Ltd. 		+86-27-84459282 sales@cfmats.com CHINA 882 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9996 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9066 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52704 58
Supplier Advantage
Alfa Chemistry
58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
career henan chemical co 		58
Hubei Co-Formula Material Tech Co., Ltd. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Baoji Guokang Healthchem Co., Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from N-Methyl-N-(trimethylsilyl)acetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Methyl-N-(trimethylsilyl)acetamide pictures 2026-06-30 N-Methyl-N-(trimethylsilyl)acetamide
7449-74-3
 1KG 90.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
N-Methyl-N-(trimethylsilyl)acetamide pictures 2026-04-17 N-Methyl-N-(trimethylsilyl)acetamide
7449-74-3
 $3.00-9.00 99% ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
N-Methyl-N-trimethylsilylacetamide pictures 2021-07-13 N-Methyl-N-trimethylsilylacetamide
7449-74-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

N-Methyl-N-(trimethylsilyl)acetamide Spectrum

N-Methyl-N-(trimethylsilyl)acetamide(7449-74-3)MSN-Methyl-N-(trimethylsilyl)acetamide(7449-74-3)1HNMRN-Methyl-N-(trimethylsilyl)acetamide(7449-74-3)13CNMR

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N-Methyl-N-TMS-acetamide Acetamide,N-methyl-N-(trimethylsilyl)- 1-(4-phenylmethoxyphenyl)-2-propanamine N-Methyl-N-trimethylsilyl-acetamide(MSA) MSA~N-Trimethylsilyl-N-methylacetamide N-Methyl-N-trimethylsilyacetamideMSA(N-Trimethylsilyl-N-methylacetamide) N-Methyl-N-trimethylsilylacetamine N-Methyl-N-(trimethylsilyl)acetamide,98% N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] [TriMethylsilylating Agent] N-Methyl-N-triMethylsilylacetaMide  N-METHYL-N-TRIMETHYLSILYACETAMIDE N-TRIMETHYLSILYL-N-METHYLACETAMIDE MOUSE ALBUMIN n-methyl-n-(trimethylsilyl)-acetamid N-Methyl-N-trimethylsilylacetamide[TrimethylsilylatingAgent]> N-Methyl-N-trimethylsilylacetamide N-Methyl-N-(trimethylsilyl)amide N-METHYL-N-TRIMETHYLSILYLACETAMIDE 7449-74-3 C6H15NOSi Si (Classes of Silicon Compounds) Silylacetamides Si-N Compounds Silylation (GC Derivatizing Reagents) Trimethylsilylation (GC Derivatizing Reagents) GC Derivatizing Reagents Derivatization Reagents Fluka Reagents Analytical Chromatography Product Catalog Analytical Chemistry GC Derivatizing Reagents Si (Classes of Silicon Compounds) Silylacetamides Silylation (GC Derivatizing Reagents) Si-N Compounds Trimethylsilylation (GC Derivatizing Reagents)