N,O-Bis(trimethylsilyl)acetamide
- CAS No.
- 10416-59-8
- Chemical Name:
- N,O-Bis(trimethylsilyl)acetamide
- Synonyms
- BSA;BIS(TRIMETHYLSILYL)ACETAMIDE;TMS-BA;TriMethylsilyl N-(triMethylsilyl)acetiMidate;trimethylsilyl N-trimethylsilylethanimidate;trimethylsilyl (E)-N-(trimethylsilyl)acetimidate;CB2500;dynasylan bsa;bis(trimethylsllyl)acetamide;N.O-Bis(trimethylsilyl)acetamide (BSA)
- CBNumber:
- CB7366985
- Molecular Formula:
- C8H21NOSi2
- Molecular Weight:
- 203.43
- MDL Number:
- MFCD00008270
- MOL File:
- 10416-59-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 24 °C |
|---|---|
| Boiling point | 71-73 °C35 mm Hg(lit.) |
| Density | 0.832 g/mL at 20 °C(lit.) |
| vapor pressure | 10 hPa (50 °C) |
| refractive index |
n |
| Flash point | 53 °F |
| storage temp. | Store below +30°C. |
| solubility | Miscible with many nonpolar and polar aprotic solvents. |
| form | Crystalline Powder, Crystals and/or Chunks |
| pka | 5.82±0.50(Predicted) |
| Specific Gravity | 0.832 |
| color | Light yellow or beige to brown |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| Sensitive | Moisture Sensitive |
| BRN | 1306669 |
| InChI | 1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+ |
| InChIKey | SIOVKLKJSOKLIF-CMDGGOBGSA-N |
| SMILES | C\C(O[Si](C)(C)C)=N/[Si](C)(C)C |
| CAS DataBase Reference | 10416-59-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | R14N49I64O |
| NIST Chemistry Reference | Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8) |
| EPA Substance Registry System | Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester (10416-59-8) |
| UNSPSC Code | 41116105 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H302-H314 | |||||||||
| Precautionary statements | P210-P233-P280-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C,Xn,F | |||||||||
| Risk Statements | 10-14-22-34-40-20/21/22-11 | |||||||||
| Safety Statements | 26-36/37/39-45-7/8-43A-36-30-23-16-7/9 | |||||||||
| RIDADR | UN 2920 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AK3000000 | |||||||||
| F | 10-21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29310095 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Flam. Liq. 3 Skin Corr. 1B |
|||||||||
| Toxicity | LD50 orally in Rabbit: 1580 mg/kg | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 1.0 L (0.3 gallon) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
N,O-Bis(trimethylsilyl)acetamide price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.18727 | N,O-Bis(trimethylsilyl)acetamide for synthesis | 10416-59-8 | 25mL | $71.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.18727 | N,O-Bis(trimethylsilyl)acetamide for synthesis | 10416-59-8 | 100mL | $197 | 2026-04-30 | Buy |
| Sigma-Aldrich | 128910 | N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% | 10416-59-8 | 10ml | $69.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 128910 | N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% | 10416-59-8 | 1l | $702 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1.09649 | N,O-Bis(trimethylsilyl)acetamide for gas chromatography | 10416-59-8 | 25mL | $200 | 2022-05-15 | Buy |
N,O-Bis(trimethylsilyl)acetamide Chemical Properties,Uses,Production
Description
Clear to yellowish clear liquid liquid which is soluble in many nonpolar and polar aprotic solvents.
The trimethylsilyl group is a frequently utilized monofunctional blocking group for protic organic and inorganic materials. As it eliminated during the silylation is neutral acetamide, N,O-Bis(trimethylsilyl)acetamide can be preferably used for substrates which are acid- or base-sensitive.
N,O-bis(trimethylsilyl)-acetamide is an effective silylating agent. It is used in the pharmaceutical and in the chemical industry. Typically the silylating reaction with BSA results in neutral by-products only.
Uses
- Used for blocking and protection of hydroxyl groups in natural products, e.g. amino acids, carbohydrates;
- Used for blocking and protection of functional groups in organic intermediates;
- Used for formation of derivatives of H-acid compounds for analysis;
Chemical Properties
Colorless or light yellow transparent liquid or solid. Boiling point 71-73℃/35mm.
Physical properties
bp 71–73°C/35 mmHg.
Uses
Powerful silylation reagent for a wide range of functional groups under mild conditions
Uses
N,O-bis(trimethylsilyl)-acetamide (BSA) is frequently used with TMCS as a catalyst to modify a variety of functional groups including carboxyl groups. In one novel application, BSA was used to measure carboxypeptidase activity by forming derivatives which could be determined by gas chromatography.BSA has been used to prepare derivatives of steroids and glucocorticoids.
Uses
N,O-Bis(trimethylsilyl)acetamide is a powerful silylating agent; reacts with a wide range of functional
groups.
BSA was used to
trimethylsilylate the hydroxyl group of 12 selectively to form
in almost quantitative yield (eq 32).The presence of catalytic
amounts (～0.02 equiv) of tetrabutylammonium fluoride (TBAF)
significantly promoted the silylation of alcohols under mild conditions
with high chemoselectivity, i.e., TBAF plays a role as a
smooth silyl transfer catalyst from nitrogen to the hydroxyl group.
Preparation
N,O-Bis(trimethylsilyl)acetamide is made by the reaction of acetamide with a large excess of chlorotrimethylsilane in the presence of triethylamine.
General Description
N,O-Bis(trimethylsilyl)acetamide is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions.
reaction suitability
reagent type: derivatization reagent
reaction type: Silylations
Purification Methods
Fractionate it through a spinning band column and collect liquid b 71-73o/35mm, and not higher because the main impurity MeCONHSiMe3 distils at b 105-107o/35mm. It is used for derivatising alcohols and sugars [Klebe et al. J Am Chem Soc 88 3390 1966, see Matsuo et al. Carbohydr Res 241 209 1993, Johnson Carbohydr Res 237 313 1992]. Itis FLAMMABLE and TOXIC.
N,O-Bis(trimethylsilyl)acetamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XPERTICK (SHANDONG) BIO-PHARMACEUTICAL CO., LTD | 21-58999881 15623240527 | emily@xtick.cn | China | 61 | 58 |
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| Jiangxi Estik Technology Development Co., Ltd | 02158999881 19892935632 | business@xpertick.cn | China | 50 | 58 |
| Zhejiang Aobang Pharmaceutical & Chemical Co. LTD | 13676682222 13676682222; | 877870302@qq.com | China | 31 | 58 |
| Nantong Jiaxingtai Biotechnology Co., Ltd. | 18795782766 | 769011731@qq.com | China | 430 | 58 |
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 726 | 60 |
| Tianjin Zhongxin Chemtech Co., Ltd. | 022-66880623 | sales@tjzxchem.com | China | 612 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
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View Lastest Price from N,O-Bis(trimethylsilyl)acetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | N,O-Bis(trimethylsilyl)acetamide
10416-59-8
|
$1.00 | 1KG | ≥99% | 2000mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-09-02 | N,O-Bis(trimethylsilyl)acetamide
10416-59-8
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | N,O-Bis(trimethylsilyl)acetamide
10416-59-8
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- N,O-Bis(trimethylsilyl)acetamide
10416-59-8
- $1.00
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- N,O-Bis(trimethylsilyl)acetamide
10416-59-8
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- N,O-Bis(trimethylsilyl)acetamide
10416-59-8
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
10416-59-8(N,O-Bis(trimethylsilyl)acetamide)Related Search:
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Reaction vial, capacity 2 ml * 8 N,O-Bis(trimethylsilyl)acetamide,95% N,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 ml * 8 / Reaction vial, capacity 2 ml * 8 [Trimethylsilylating Reagent, for NH2 compounds] Bis(trimethylsilyl)acetamide 5g [10416-59-8] N,O-Bis(trimethylsil TMS-BA (25% in Acetonitrile) 1 ML * 8 / Reaction vial, capacity 2 ML * 8 [TriMethylsilylating Reagent, for NH2 coMpounds] N,O-Bis(triMethylsilyl)acetaMide, 95% 100ML N,O-Bis(triMethylsilyl)acetaMide, 95% 25ML TMS-BA BSA N,O-Bis(triMethylsilyl)acetaMide Kit Ht--406 Bis(Trimethylsilyl)Acetamide (Bsa) N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 mL * 8 / Reaction vial, capacity 2 mL * 8> BSA [=N,O-Bis(trimethylsilyl)acetamide][for Gas Chromatography]> N,O-Bis(trimethylsilyl)acetamide >
