Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide Structure
N,O-Bis(trimethylsilyl)acetamide structure
CAS No.
10416-59-8
Chemical Name:
N,O-Bis(trimethylsilyl)acetamide
Synonyms
BSA;BIS(TRIMETHYLSILYL)ACETAMIDE;TriMethylsilyl N-(triMethylsilyl)acetiMidate;TMS-BA;dynasylan bsa;bis(trimethylsllyl)acetamide;N.O-Bis(trimethylsilyl)acetamide (BSA);(E)-TriMethylsilyl N-(triMethylsilyl)acetiMidate;trimethylsilyl (1E)-N-trimethylsilylethanimidate;BSiA
CBNumber:
CB7366985
Molecular Formula:
C8H21NOSi2
Molecular Weight:
203.43
MDL Number:
MFCD00008270
MOL File:
10416-59-8.mol
MSDS File:
SDS
Last updated:2025-11-21 15:10:21
Product description Number Pack Size Price
N,O-Bis(trimethylsilyl)acetamide for synthesis 8.18727 25mL $67.3
N,O-Bis(trimethylsilyl)acetamide for synthesis 8.18727 100mL $185
N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 128910 10ml $65
N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 128910 1l $659
N,O-Bis(trimethylsilyl)acetamide for gas chromatography 1.09649 25mL $200
More product size
Request For Quotation

N,O-Bis(trimethylsilyl)acetamide Properties

Melting point 24 °C
Boiling point 71-73 °C35 mm Hg(lit.)
Density 0.832 g/mL at 20 °C(lit.)
vapor pressure 10 hPa (50 °C)
refractive index n20/D 1.417(lit.)
Flash point 53 °F
storage temp. Store below +30°C.
solubility Miscible with many nonpolar and polar aprotic solvents.
form Crystalline Powder, Crystals and/or Chunks
pka 5.82±0.50(Predicted)
Specific Gravity 0.832
color Light yellow or beige to brown
Hydrolytic Sensitivity 7: reacts slowly with moisture/water
Sensitive Moisture Sensitive
BRN 1306669
CAS DataBase Reference 10416-59-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII R14N49I64O
NIST Chemistry Reference Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8)
EPA Substance Registry System Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester (10416-59-8)
UNSPSC Code 41116105
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS05,GHS07
Signal word  Danger
Hazard statements  H226-H302-H314
Precautionary statements  P210-P233-P280-P301+P312-P303+P361+P353-P305+P351+P338
Hazard Codes  C,Xn,F
Risk Statements  10-14-22-34-40-20/21/22-11
Safety Statements  26-36/37/39-45-7/8-43A-36-30-23-16-7/9
RIDADR  UN 2920 8/PG 2
WGK Germany  3
RTECS  AK3000000
F  10-21
TSCA  TSCA listed
HazardClass  8
PackingGroup  II
HS Code  29310095
Toxicity LD50 orally in Rabbit: 1580 mg/kg
Limited Quantities 1.0 L (0.3 gallon) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
3
3 0
W

N,O-Bis(trimethylsilyl)acetamide price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18727 N,O-Bis(trimethylsilyl)acetamide for synthesis 10416-59-8 25mL $67.3 2025-07-31 Buy
Sigma-Aldrich 8.18727 N,O-Bis(trimethylsilyl)acetamide for synthesis 10416-59-8 100mL $185 2025-07-31 Buy
Sigma-Aldrich 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 10416-59-8 10ml $65 2025-07-31 Buy
Sigma-Aldrich 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 10416-59-8 1l $659 2025-07-31 Buy
Sigma-Aldrich 1.09649 N,O-Bis(trimethylsilyl)acetamide for gas chromatography 10416-59-8 25mL $200 2022-05-15 Buy
Product number Packaging Price Buy
8.18727 25mL $67.3 Buy
8.18727 100mL $185 Buy
128910 10ml $65 Buy
128910 1l $659 Buy
1.09649 25mL $200 Buy

N,O-Bis(trimethylsilyl)acetamide Chemical Properties,Uses,Production

Description

Clear to yellowish clear liquid liquid which is soluble in many nonpolar and polar aprotic solvents.
The trimethylsilyl group is a frequently utilized monofunctional blocking group for protic organic and inorganic materials. As it eliminated during the silylation is neutral acetamide, N,O-Bis(trimethylsilyl)acetamide can be preferably used for substrates which are acid- or base-sensitive.
N,O-bis(trimethylsilyl)-acetamide is an effective silylating agent. It is used in the pharmaceutical and in the chemical industry. Typically the silylating reaction with BSA results in neutral by-products only.

Uses

  1. Used for blocking and protection of hydroxyl groups in natural products, e.g. amino acids, carbohydrates;
  2. Used for blocking and protection of functional groups in organic intermediates;
  3. Used for formation of derivatives of H-acid compounds for analysis;
The silylated derivatives are volatile and can therefore be determined by gas chromatography. Deblocking is preferably carried out by means of hydrolysis, giving high yields. In some cases, thermal elimination of the trimethylsilyl group is possible.

Chemical Properties

Colorless or light yellow transparent liquid or solid. Boiling point 71-73℃/35mm.

Physical properties

bp 71–73°C/35 mmHg.

Uses

Powerful silylation reagent for a wide range of functional groups under mild conditions

Uses

N,O-bis(trimethylsilyl)-acetamide (BSA) is frequently used with TMCS as a catalyst to modify a variety of functional groups including carboxyl groups. In one novel application, BSA was used to measure carboxypeptidase activity by forming derivatives which could be determined by gas chromatography.BSA has been used to prepare derivatives of steroids and glucocorticoids.

Uses

N,O-Bis(trimethylsilyl)acetamide is a powerful silylating agent; reacts with a wide range of functional groups.
BSA was used to trimethylsilylate the hydroxyl group of 12 selectively to form in almost quantitative yield (eq 32).The presence of catalytic amounts (～0.02 equiv) of tetrabutylammonium fluoride (TBAF) significantly promoted the silylation of alcohols under mild conditions with high chemoselectivity, i.e., TBAF plays a role as a smooth silyl transfer catalyst from nitrogen to the hydroxyl group.

Preparation

N,O-Bis(trimethylsilyl)acetamide is made by the reaction of acetamide with a large excess of chlorotrimethylsilane in the presence of triethylamine.

General Description

N,O-Bis(trimethylsilyl)acetamide is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions.

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

Purification Methods

Fractionate it through a spinning band column and collect liquid b 71-73o/35mm, and not higher because the main impurity MeCONHSiMe3 distils at b 105-107o/35mm. It is used for derivatising alcohols and sugars [Klebe et al. J Am Chem Soc 88 3390 1966, see Matsuo et al. Carbohydr Res 241 209 1993, Johnson Carbohydr Res 237 313 1992]. Itis FLAMMABLE and TOXIC.

N,O-Bis(trimethylsilyl)acetamide Preparation Products And Raw materials

Raw materials

Triethylamine hydrochloride Acetamide Toluene Chlorotrimethylsilane

Preparation Products

N-Methyl-N-(trimethylsilyl)trifluoroacetamide N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine 2-METHYL-1-(TRIMETHYLSILOXY)-1-PROPENE 1-Cyclohexenyloxytrimethylsilane 1-(Trimethylsiloxy)cyclopentene
β-D-Glucopyranose, 1,6-anhydro-2,3,4-tris-O-(trimethylsilyl)- [(11-Fluoroundecyl)oxy]trimethylsilane Pyrimidine, 5-methyl-4-[(trimethylsilyl)oxy]-2-[(trimethylsilyl)thio]-

1of2

N,O-Bis(trimethylsilyl)acetamide Suppliers

Global( 723)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Medfine Bio-pharmaceutical Co., Ltd
+86-86-13013810076 +8619921460217 tina.lv@bio-medfine.com China 296 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5244 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20130 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13588 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21604 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
Supplier Advantage
Shanghai Medfine Bio-pharmaceutical Co., Ltd
58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55

Related articles

View Lastest Price from N,O-Bis(trimethylsilyl)acetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N,O-Bis(trimethylsilyl)acetamide pictures 2026-01-05 N,O-Bis(trimethylsilyl)acetamide
10416-59-8
 US $1.00 / KG 1KG ≥99% 2000mt/year Jinan Finer Chemical Co., Ltd
N,O-Bis(trimethylsilyl)acetamide pictures 2025-12-01 N,O-Bis(trimethylsilyl)acetamide
10416-59-8
 US $0.00 / kg 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
N,O-Bis(trimethylsilyl)acetamide pictures 2025-09-25 N,O-Bis(trimethylsilyl)acetamide
10416-59-8
 US $8.00-0.80 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

N,O-Bis(trimethylsilyl)acetamide Spectrum

N,O-Bis(trimethylsilyl)acetamide(10416-59-8)MSN,O-Bis(trimethylsilyl)acetamide(10416-59-8)1HNMRN,O-Bis(trimethylsilyl)acetamide(10416-59-8)IR1N,O-Bis(trimethylsilyl)acetamide(10416-59-8)Raman

10416-59-8(N,O-Bis(trimethylsilyl)acetamide)Related Search:

Acetamide N-(Trimethylsilyl)acetamide Acetaminophen 2-Cyanoacetamide 2,2,2-TRIFLUORO-N,O-BIS(TRIMETHYLSILYL)-ACETAMIDE,Trifluoro-N,O-bis(trimethylsilyl)acetamide,N,O-bis(trimethylsilyl)acetamide,*with 10%
Thioacetamide tert-Butyldimethylsilyl chloride N,N'-Methylenebisacrylamide N,N'-Dimethyl-1,2-ethanediamine N,N-Bis(2-cyanoethyl)formamide
TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE N,N'-BIS(3-AMINOPROPYL)ETHYLENEDIAMINE N,N-Dimethylacetamide 2,2-Bis(trimethylsilyl)acetamide 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-Acetamid
TRIMETHYLSILANE Bovine albumin N,O-BIS(TERT-BUTYLDIMETHYLSILYL)ACETAMIDE

1of4

dynasylan bsa Co-Formula CFS-598 trimethylsilyl N-trimethylsilylethanimidate BIS(TRIMETHYLSILYL)ACETAMIDE Acetimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester bis(trimethylsllyl)acetamide CB2500 Ethanimidicacid,N-(trimethylsilyl)-,trimethylsilylester N-(Trimethylsilyl)acetimidic acid, trimethylsilyl ester n-(trimethylsilyl)acetimidicacid,trimethylsilylester N.O-Bis(trimethylsilyl)acetamide (BSA) N,O-BIS(TRIMETHYLSILYL)ACETAMIDE SET WIT H 10 X 1 ML N,O-Bis(trimethyl-d9-silyl)acetamide (BSA-d18), 98% CP, 99 atom % D N,O-BIS(TRIMETHYLSILYL)ACETAMIDE, FOR GC N,O-BIS(TRIMETHYLSILYL)ACETAMIDE, DERIVA N,O-BIS(TRIMETHYLSILYL)ACETAMIDE, WITH 5 % TMCS N,O-BIS-(TRIMETHYLSILYL)ACETAMIDE*(BSA) BULK PACKAG N,O-BIS(TRIMETHYLSILYL)ACETAMIDE 98+% TMS-BA [=N,O-BIS(TRIMETHYLSILYL)ACETAMIDE] 25% IN ACETONITRILE [FOR GAS CHROMATOGRAPHY] BIS-(TRIMETHYL SILYL) ACETAMIDE (BSA) N,O-Bis(Trimethylsilyl)Acetamide(Bsa),Antibiotics N,O-BIS(TRIMETHYLSILY)ACETAMIDE DYNASYLAN BSATrimethylsilyl N-trimethylsilylacetamidate N,O-BIS(TRIMETHYLSILYL)ACETAMIDE N,O-Bistrimethyl Sylyl Acetamide BSA [=N,O-Bis(trimethylsilyl)acetamide] [for Gas Chromatography] N,O-Bis(trimethylsilyl)acetamide (25% in Acetonitrile) [Trimethylsilylating Reagent, for NH2 compounds] N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 ml * 8 / Reaction vial, capacity 2 ml * 8 N,O-Bis(triMethylsilyl)ac... BSA N,O-BIS(TRIMETHYLSILYL)ACETAMIDE FOR GAS TriMethylsilyl N-(triMethylsilyl)acetiMidate Trimethylsilyl N-(trimethylsilyl)ethanimidate, N,O-Bis(trimethylsilyl)acetamide, BSA |N|,|O|-Bis(triMethylsilyl)acetaMide (TMS-BA) (E)-TriMethylsilyl N-(triMethylsilyl)acetiMidate BSA (25% in Acetonitrile) N,O-Bis(triMethylsilyl)acetaMide synthesis grade, >=95% N-(Trimethylsilyl)ethanimidic acid trimethylsilyl ester N,O-Bis(trimethylsilyl)acetamide≥ 95% (Assay) N,O-Bis(trimethylsiyl)acetamide 99%min n-(trimethylsilyl)-acetimidicacitrimethylsilylester n-(trimethylsilyl)-ethanimidicacitrimethylsilylester Trimethylsilyl N-trimethylsilylacetamidate TMS-BA NO-Bis (trimethylsilyl) acetamide 90+ % gas chromatography N,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 ml * 8 / Reaction vial, capacity 2 ml * 8 Trimethylsilyl (1E)-N-[(E)-trimethylsilyl]ethanimidoate N-Trimethylsilyl-1-trimethylsilyloxyethanimine 1-(Trimethylsiloxy)-N-(trimethylsilyl)ethanimine N-(Trimethylsilyl)-1-(trimethylsiloxy)ethanimine N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 ml * 8
Reaction vial, capacity 2 ml * 8 N,O-Bis(trimethylsilyl)acetamide,95% N,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 ml * 8 / Reaction vial, capacity 2 ml * 8 [Trimethylsilylating Reagent, for NH2 compounds] Bis(trimethylsilyl)acetamide 5g [10416-59-8] N,O-Bis(trimethylsil TMS-BA (25% in Acetonitrile) 1 ML * 8 / Reaction vial, capacity 2 ML * 8 [TriMethylsilylating Reagent, for NH2 coMpounds] N,O-Bis(triMethylsilyl)acetaMide, 95% 100ML N,O-Bis(triMethylsilyl)acetaMide, 95% 25ML