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Ethyl 4,4-difluoro-3-oxobutanoate

Ethyl 4,4-difluoro-3-oxobutanoate Structure
Ethyl 4,4-difluoro-3-oxobutanoate structure
CAS No.
352-24-9
Chemical Name:
Ethyl 4,4-difluoro-3-oxobutanoate
Synonyms
ETHYL 4,4-DIFLUOROACETOACETATE;ETHYL 4,4-DIFLUORO-3-OXOBUTYRATE;4,4-Difluoroacetoacetic acid ethyl ester;AKOS B016254;AKOS MSC-0700;Ethyl 4,4-difluoroc;ART-CHEM-BB B016254;Difluoro aceto acetat;4-difluoro-3-oxobutanoate;4,4-Difluoroacylacidester
CBNumber:
CB4359962
Molecular Formula:
C6H8F2O3
Molecular Weight:
166.12
MDL Number:
MFCD00039277
MOL File:
352-24-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:03:24
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Ethyl 4,4-difluoro-3-oxobutanoate Properties

Melting point -46°C(lit.)
Boiling point 162 °C
Density 1,61 g/cm3
refractive index 1.407
Flash point 68℃
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form clear liquid
pka 8.61±0.46(Predicted)
color Colorless to Almost colorless
InChI InChI=1S/C6H8F2O3/c1-2-11-5(10)3-4(9)6(7)8/h6H,2-3H2,1H3
InChIKey CBDPWKVOPADMJC-UHFFFAOYSA-N
SMILES C(OCC)(=O)CC(=O)C(F)F
CAS DataBase Reference 352-24-9(CAS DataBase Reference)
EPA Substance Registry System Ethyl 4,4-difluoroacetoacetate (352-24-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Warning
Hazard statements  H315-H319-H226
Precautionary statements  P305+P351+P338-P210-P280a-P303+P361+P353-P501a
Hazard Codes  F,Xi
Risk Statements  10-36/37/38-36/38
Safety Statements  26-36/37/39
RIDADR  1993
WGK Germany  3
Hazard Note  Flammable
TSCA  TSCA listed
HazardClass  IRRITANT, FLAMMABLE
HazardClass  3
HS Code  2918300090
NFPA 704
2
2 0

Ethyl 4,4-difluoro-3-oxobutanoate price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical E1018 Ethyl 4,4-Difluoroacetoacetate >96.0%(GC) 352-24-9 5g $30 2021-12-16 Buy
TCI Chemical E1018 Ethyl 4,4-Difluoroacetoacetate >96.0%(GC) 352-24-9 25g $65 2026-04-30 Buy
Usbiological 237645 Ethyl 4,4-difluoroacetoacetate ≥95% (NMR) ≥95%(NMR) 352-24-9 1g $156 2026-06-03 Buy
Usbiological 237645 Ethyl 4,4-difluoroacetoacetate ≥95% (NMR) ≥95%(NMR) 352-24-9 5g $170 2026-06-03 Buy
Usbiological 237645 Ethyl 4,4-difluoroacetoacetate ≥95% (NMR) ≥95%(NMR) 352-24-9 25g $295 2026-06-03 Buy
Product number Packaging Price Buy
E1018 5g $30 Buy
E1018 25g $65 Buy
237645 1g $156 Buy
237645 5g $170 Buy
237645 25g $295 Buy

Ethyl 4,4-difluoro-3-oxobutanoate Chemical Properties, Uses, Production

Uses

Ethyl 4,4-difluoro-3-oxobutanoate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists.

Uses

Ethyl 4,4-Difluoroacetoacetate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists.

Ethyl 4,4-difluoro-3-oxobutanoate synthesis

454-31-9
141-78-6
352-24-9
Synthesis of Ethyl 4,4-difluoro-3-oxobutanoate from Ethyl difluoroacetate and Ethyl acetate

Ethyl 4,4-difluoro-3-oxobutanoate Preparation Products And Raw materials

Raw materials

Preparation Products

4,4-Difluoro-3-hydroxy-butyric acid ethyl ester Ethyl5-(aminomethyl)-2-(difluoromethyl)pyridine-4-carboxylate

Ethyl 4,4-difluoro-3-oxobutanoate Suppliers

Global Suppliers ( 399)
Supplier Tel Email Country ProdList Advantage
Jinan Wanxingda Chemical Co., Ltd. 0531-88064106 18253116016 bruce@wxdchem.com China 14 58
West fluorine technology co., ltd 0531-85906692 15588812394 325912682@qq.com China 370 58
jinanzhonglanhuagongyouxiangongsi 15169176553; 15169176553 644658103@qq.com China 32 58
Jinan Langhua Chemical Co., Ltd 0531-85906691 18660816586 325912681@qq.com China 212 58
Jinan Wanxingda New Material Technology Co., Ltd. 0531-88064106 18253116016 zhangjia@wxdchem.com China 44 58
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Supplier Advantage
Jinan Wanxingda Chemical Co., Ltd. 58
West fluorine technology co., ltd 58
jinanzhonglanhuagongyouxiangongsi 58
Jinan Langhua Chemical Co., Ltd 58
Jinan Wanxingda New Material Technology Co., Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
INTATRADE GmbH 66
Alfa Aesar 84
Ark Pharm, Inc. 56

View Latest Price from Ethyl 4,4-difluoro-3-oxobutanoate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl 4,4-difluoro-3-oxobutanoate pictures 2026-08-25 Ethyl 4,4-difluoro-3-oxobutanoate
352-24-9
 $85.00-850.00 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
Ethyl 4,4-difluoro-3-oxobutanoate pictures 2026-06-30 Ethyl 4,4-difluoro-3-oxobutanoate
352-24-9
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
Ethyl 4,4-difluoroacetoacetate pictures 2026-05-28 Ethyl 4,4-difluoroacetoacetate
352-24-9
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD

Ethyl 4,4-difluoro-3-oxobutanoate Spectrum

Ethyl 4,4-difluoro-3-oxobutanoate(352-24-9)1HNMREthyl 4,4-difluoro-3-oxobutanoate(352-24-9)FT-IR

352-24-9 (Ethyl 4,4-difluoro-3-oxobutanoate) Related Search:

Isopropyl 4,4,4-trifluoroacetoacetate Ethyl 2-methyl-4,4,4-trifluoroacetoacetate Ethyl acetoacetate Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate Ethyl 4,4-difluoro-3-oxobutanoate
Ethyl 4,4,4-trifluoroacetoacetate Ethyl 2-chloro-4,4,4-trifluoroacetoacetate Ethyl heptafluorobutyrylacetate Ethyl pentafluoropropionylacetate Ethyl 2,2-difluoroacetoacetate
4,4,4-Trifluoro-2-hydroxylimino-3-oxobutyric acid ethyl ester Ethyl 4,4,4-trifluoro-2-methoxy-3-oxobutyrate 4,4,4-Trifluoro-acetoacetic acid tert-butyl ester Ethyl 4,4,4-trifluoro-2-(triphenylphosphoranylidene)acetoacetate Ethyl 3-([2-acetyl-5-(tert-butyl)-3-thienyl]amino)-2-(2,2,2-trifluoroacetyl)acrylate
Methyl 2-([2-(ethoxycarbonyl)-4,4,4-trifluoro-3-oxobut-1-enyl]amino)benzoate Methyl 4-([2-(ethoxycarbonyl)-4,4,4-trifluoro-3-oxobut-1-enyl]amino)thiophene-3-carboxylate Methyl 2-([2-(ethoxycarbonyl)-4,4,4-trifluoro-3-oxobut-1-enyl]amino)thiophene-3-carboxylate

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AKOS MSC-0700 AKOS B016254 ETHYL 4,4-DIFLUORO-3-OXOBUTYRATE ART-CHEM-BB B016254 Difluoro aceto acetat Ethyl 4,4-difluoro-3-oxobutyrate 90% Ethyl4,4-difluoro-3-oxobutyrate90% Ethyl 4,4-difluoro-3-oxobutanoate 4,4-Difluoro-3-oxo butyric acid ethyl ester Ethyl 4,4-difluoro-3-oxobutanoate 90% Ethyl 4,4-difluoroc 4,4-difluoro-3-oxobutanoate 3-Oxo-4,4-difluorobutanoic acid ethyl ester 3-Oxo-4,4-difluorobutyric acid ethyl ester 4-difluoro-3-oxobutanoate Butanoic acid,4,4-difluoro-3-oxo-, ethyl ester Ethyl-4 4-difluoroacetoacetate- >98% -purity (Pack 100GM X 3 Nos) Ethyl 4,4-difluoro-3-oxobutyrate, Ethyl 4,4-difluoro-3-oxobutanoate Ethyl 4,4-difluorocetoacetate SynonyMs Ethyl 4,4-difluoro-3-oxobutanoate 4,4-difluoro-ethyl acetoacetate Ethyl 4,4-difluorocetoacetate 4,4-Difluoro-3-oxobutanoic acid ethyl ester Ethyl 4,4-difluoro-3-ketobutyrate Ethyl4,4-Difluoroacetoacetate> TIANFU CHEM---Ethyl 4,4-difluoro-3-oxobutanoate Butanoic acid, 4,4-difluoro-3-oxo-, ethyl ester (9CI, ACI) 4,4-difluoro-3-oxo-Butanoic acid ethyl ester (9CI ACI) 4,4-Difluoroacylacidester Ethyl4,4-difluoro-3-oxobutyrat Difluoroacetoacetate Ethyl 4,4-Difluoroacetoacetic acid ethyl ester ETHYL 4,4-DIFLUOROACETOACETATE 352-24-9 top