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Ethyl 4,4-difluoro-3-oxobutanoate

Ethyl 4,4-difluoro-3-oxobutanoate structure

CAS No.: 352-24-9

Chemical Name:: Ethyl 4,4-difluoro-3-oxobutanoate

Synonyms: ETHYL 4,4-DIFLUOROACETOACETATE;ETHYL 4,4-DIFLUORO-3-OXOBUTYRATE;4,4-Difluoroacetoacetic acid ethyl ester;AKOS B016254;AKOS MSC-0700;Ethyl 4,4-difluoroc;ART-CHEM-BB B016254;Difluoro aceto acetat;4-difluoro-3-oxobutanoate;4,4-Difluoroacylacidester

CBNumber:: CB4359962

Molecular Formula:: C6H8F2O3

Molecular Weight:: 166.12

MDL Number:: MFCD00039277

MOL File:: 352-24-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 06:03:24

Product description	Number	Pack Size	Price
Ethyl 4,4-Difluoroacetoacetate >96.0%(GC)	E1018	5g	$30
Ethyl 4,4-Difluoroacetoacetate >96.0%(GC)	E1018	25g	$65
Ethyl 4,4-difluoroacetoacetate ≥95% (NMR) ≥95%(NMR)	237645	1g	$156
Ethyl 4,4-difluoroacetoacetate ≥95% (NMR) ≥95%(NMR)	237645	5g	$170
Ethyl 4,4-difluoroacetoacetate ≥95% (NMR) ≥95%(NMR)	237645	25g	$295
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Ethyl 4,4-difluoro-3-oxobutanoate Properties

Melting point	-46°C(lit.)
Boiling point	162 °C
Density	1,61 g/cm³
refractive index	1.407
Flash point	68℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	clear liquid
pka	8.61±0.46(Predicted)
color	Colorless to Almost colorless
InChI	InChI=1S/C6H8F2O3/c1-2-11-5(10)3-4(9)6(7)8/h6H,2-3H2,1H3
InChIKey	CBDPWKVOPADMJC-UHFFFAOYSA-N
SMILES	C(OCC)(=O)CC(=O)C(F)F
CAS DataBase Reference	352-24-9(CAS DataBase Reference)
EPA Substance Registry System	Ethyl 4,4-difluoroacetoacetate (352-24-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Warning

Hazard statements

H315-H319-H226

Precautionary statements

P305+P351+P338-P210-P280a-P303+P361+P353-P501a

Hazard Codes

F,Xi

Risk Statements

10-36/37/38-36/38

Safety Statements

26-36/37/39

RIDADR

1993

WGK Germany

Hazard Note

Flammable

TSCA

TSCA listed

HazardClass

IRRITANT, FLAMMABLE

HazardClass

HS Code

2918300090

NFPA 704

	2
2		0

Ethyl 4,4-difluoro-3-oxobutanoate price More Price(69)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	E1018	Ethyl 4,4-Difluoroacetoacetate >96.0%(GC)	352-24-9	5g	$30	2021-12-16	Buy
TCI Chemical	E1018	Ethyl 4,4-Difluoroacetoacetate >96.0%(GC)	352-24-9	25g	$65	2026-04-30	Buy
Usbiological	237645	Ethyl 4,4-difluoroacetoacetate ≥95% (NMR) ≥95%(NMR)	352-24-9	1g	$156	2026-06-03	Buy
Usbiological	237645	Ethyl 4,4-difluoroacetoacetate ≥95% (NMR) ≥95%(NMR)	352-24-9	5g	$170	2026-06-03	Buy
Usbiological	237645	Ethyl 4,4-difluoroacetoacetate ≥95% (NMR) ≥95%(NMR)	352-24-9	25g	$295	2026-06-03	Buy

Product number	Packaging	Price	Buy
E1018	5g	$30	Buy
E1018	25g	$65	Buy
237645	1g	$156	Buy
237645	5g	$170	Buy
237645	25g	$295	Buy

Ethyl 4,4-difluoro-3-oxobutanoate Chemical Properties,Uses,Production

Uses

Ethyl 4,4-difluoro-3-oxobutanoate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists.

Uses

Ethyl 4,4-Difluoroacetoacetate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists.

Ethyl 4,4-difluoro-3-oxobutanoate synthesis

Synthesis of Ethyl 4,4-difluoro-3-oxobutanoate from Ethyl difluoroacetate and Ethyl acetate

Ethyl 4,4-difluoro-3-oxobutanoate Preparation Products And Raw materials

Raw materials

Preparation Products

4,4-Difluoro-3-hydroxy-butyric acid ethyl ester Ethyl5-(aminomethyl)-2-(difluoromethyl)pyridine-4-carboxylate

Ethyl 4,4-difluoro-3-oxobutanoate Suppliers

Global( 393)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5224	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9333	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Zibo Shiji Zhonglian Medical Technology Co., Ltd.	15069388126 15069388126;	sales@sjzlpharm.com	China	65	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14026	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60

Supplier	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Aochuang Chemical Co.,Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Zibo Shiji Zhonglian Medical Technology Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Fluoropharm Co., Ltd.	60

View Lastest Price from Ethyl 4,4-difluoro-3-oxobutanoate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-06	Ethyl 4,4-difluoro-3-oxobutanoate 352-24-9	$85.00-850.00	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2026-06-30	Ethyl 4,4-difluoro-3-oxobutanoate 352-24-9		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-05-28	Ethyl 4,4-difluoroacetoacetate 352-24-9	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD

Ethyl 4,4-difluoro-3-oxobutanoate
352-24-9
$85.00-850.00
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

Ethyl 4,4-difluoro-3-oxobutanoate
352-24-9
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

Ethyl 4,4-difluoroacetoacetate
352-24-9
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

Ethyl 4,4-difluoro-3-oxobutanoate Spectrum

Ethyl 4,4-difluoro-3-oxobutanoate(352-24-9)¹HNMR Ethyl 4,4-difluoro-3-oxobutanoate(352-24-9)FT-IR

352-24-9(Ethyl 4,4-difluoro-3-oxobutanoate)Related Search:

Ethyl 2-chloro-4,4,4-trifluoroacetoacetate Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate ETHYL PENTAFLUOROPROPIONYLACETATE Ethyl 4,4-difluoro-3-oxobutanoate Ethyl 4,4,4-trifluoroacetoacetate

ETHYL HEPTAFLUOROBUTYRYLACETATE ETHYL 2-METHYL-4,4,4-TRIFLUOROACETOACETATE ISOPROPYL 4,4,4-TRIFLUOROACETOACETATE ETHYL 2,2-DIFLUOROACETOACETATE Ethyl acetoacetate

ETHYL 4,4,4-TRIFLUORO-2-(TRIPHENYLPHOSPHORANYLIDENE)ACETOACETATE 4,4,4-TRIFLUORO-ACETOACETIC ACID TERT-BUTYL ESTER 4,4,4-TRIFLUORO-2-HYDROXYLIMINO-3-OXOBUTYRIC ACID ETHYL ESTER ETHYL 4,4,4-TRIFLUORO-2-METHOXY-3-OXOBUTYRATE ETHYL 3-([2-ACETYL-5-(TERT-BUTYL)-3-THIENYL]AMINO)-2-(2,2,2-TRIFLUOROACETYL)ACRYLATE

METHYL 4-([2-(ETHOXYCARBONYL)-4,4,4-TRIFLUORO-3-OXOBUT-1-ENYL]AMINO)THIOPHENE-3-CARBOXYLATE METHYL 2-([2-(ETHOXYCARBONYL)-4,4,4-TRIFLUORO-3-OXOBUT-1-ENYL]AMINO)BENZOATE METHYL 2-([2-(ETHOXYCARBONYL)-4,4,4-TRIFLUORO-3-OXOBUT-1-ENYL]AMINO)THIOPHENE-3-CARBOXYLATE

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AKOS MSC-0700 AKOS B016254 ETHYL 4,4-DIFLUORO-3-OXOBUTYRATE ART-CHEM-BB B016254 Difluoro aceto acetat Ethyl 4,4-difluoro-3-oxobutyrate 90% Ethyl4,4-difluoro-3-oxobutyrate90% Ethyl 4,4-difluoro-3-oxobutanoate 4,4-Difluoro-3-oxo butyric acid ethyl ester Ethyl 4,4-difluoro-3-oxobutanoate 90% Ethyl 4,4-difluoroc 4,4-difluoro-3-oxobutanoate 3-Oxo-4,4-difluorobutanoic acid ethyl ester 3-Oxo-4,4-difluorobutyric acid ethyl ester 4-difluoro-3-oxobutanoate Butanoic acid,4,4-difluoro-3-oxo-, ethyl ester Ethyl-4 4-difluoroacetoacetate- >98% -purity (Pack 100GM X 3 Nos) Ethyl 4,4-difluoro-3-oxobutyrate, Ethyl 4,4-difluoro-3-oxobutanoate Ethyl 4,4-difluorocetoacetate SynonyMs Ethyl 4,4-difluoro-3-oxobutanoate 4,4-difluoro-ethyl acetoacetate Ethyl 4,4-difluorocetoacetate 4,4-Difluoro-3-oxobutanoic acid ethyl ester Ethyl 4,4-difluoro-3-ketobutyrate Ethyl4,4-Difluoroacetoacetate> TIANFU CHEM---Ethyl 4,4-difluoro-3-oxobutanoate Butanoic acid, 4,4-difluoro-3-oxo-, ethyl ester (9CI, ACI) 4,4-difluoro-3-oxo-Butanoic acid ethyl ester (9CI ACI) 4,4-Difluoroacylacidester Ethyl4,4-difluoro-3-oxobutyrat Difluoroacetoacetate Ethyl 4,4-Difluoroacetoacetic acid ethyl ester ETHYL 4,4-DIFLUOROACETOACETATE 352-24-9 top