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Diglycolic anhydride

CAS No.
4480-83-5
Chemical Name:
Diglycolic anhydride
Synonyms
1,4-DIOXANE-2,6-DIONE;4-Maleimidobutyric acid hydrazide hydrochloride;SKL267;p-Dioxane-2,6-dione;digylcolic anhydride;DIGLYCOLIC ANHYDRIDE;Oxydiacetic anhydride;1,4-DIOXINE-2,6-DIONE;DiglycolicAnhydride>Diglycolicanhydride,95%
CBNumber:
CB4361550
Molecular Formula:
C4H4O4
Molecular Weight:
116.07
MDL Number:
MFCD00006677
MOL File:
4480-83-5.mol
MSDS File:
SDS
Last updated:2026-05-28 06:05:03

Diglycolic anhydride Properties

Melting point 92-93 °C (lit.)
Boiling point 240-241 °C (lit.)
Density 1.4230
refractive index 1.5800 (estimate)
Flash point 240-241°C
storage temp. Store below +30°C.
solubility Soluble in chloroform.
form Crystalline Powder, Crystals or Needles
color White to pale cream
Sensitive Moisture Sensitive
BRN 112527
Stability Hygroscopic, Moisture Sensitive
InChI 1S/C4H4O4/c5-3-1-7-2-4(6)8-3/h1-2H2
InChIKey PIYNUZCGMLCXKJ-UHFFFAOYSA-N
SMILES O=C1COCC(=O)O1
CAS DataBase Reference 4480-83-5(CAS DataBase Reference)
FDA UNII RKE2JJ6VPJ
NIST Chemistry Reference 1,4-Dioxane-2,6-dione(4480-83-5)
UNSPSC Code 12352115
NACRES NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
RIDADR  2923
WGK Germany  3
10-21
HazardClass  8
PackingGroup  III
HS Code  29189090
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 1

Diglycolic anhydride price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D103705 Diglycolic anhydride technical grade, 90% 4480-83-5 25g $187 2026-04-30 Buy
Sigma-Aldrich D103705 Diglycolic anhydride technical grade, 90% 4480-83-5 5g $57.2 2023-06-20 Buy
TCI Chemical D2308 Diglycolic Anhydride >95.0%(T) 4480-83-5 25g $77 2026-04-30 Buy
TCI Chemical D2308 Diglycolic Anhydride >98.0%(T) 4480-83-5 100g $256 2026-04-30 Buy
Biosynth FD11051 Diglycolic anhydride 4480-83-5 0.5kg $649 2026-06-04 Buy
Product number Packaging Price Buy
D103705 25g $187 Buy
D103705 5g $57.2 Buy
D2308 25g $77 Buy
D2308 100g $256 Buy
FD11051 0.5kg $649 Buy

Diglycolic anhydride Chemical Properties, Uses, Production

Chemical Properties

white to off-white

Uses

Diglycolic anhydride is used in the preparation of N,N-diethyldiglycollamsaeure by reacting with diethylamine. It is an useful bio chemical for proteomics research.

Synthesis

50.01 g of diglycolic acid was dissolved in 140 mL of acetic anhydride, Heated to 145 ℃, Add 5 drops of phosphoric acid as initiator, And the mixture was refluxed for 2 hours. After the reaction was stopped, Most acetic anhydride was removed by rotary evaporation at 80 ℃. Approximately 100 mL of liquid was obtained,300 mL of toluene was added. Stirring, and allowed to stand for 10 hours. Vacuum filtration to give 38.89g colourless to white Diglycolic anhydride crystals. The yield was 90%.

Diglycolic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

Global Suppliers ( 277)
Supplier Tel Email Country ProdList Advantage
Shijiazhuang Surui Chemical Co., LTD 15833970389 15833970389 sjzkhhg@126.com China 36 58
Chongqing Xingcan Pharmaceutical Technology Co., Ltd. 13594048950 19923294409 xingcanyaoye@sina.com China 1591 58
Nantong Xiaochang Pharmaceutical Trading Co., Ltd. 0513-82104991 18862997351 sales11@btcpharm.com China 859 58
Zhenjiang D&A Biological Technology Co., Ltd. 18912101619 wxf2005a@126.com China 95 58
Shanghai Witofly Chemical Co. ,Ltd. 02150630626 17717886015 sales@witofly.com China 1864 55
Shanghai Taijilin Industrial Co., Ltd. 02150630626 17717886015 kate@tajilin.com China 1341 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81

View Latest Price from Diglycolic anhydride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Diglycolic Anhydride pictures 2026-09-17 Diglycolic Anhydride
4480-83-5
$1.00 100g 97.0%min 20kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Diglycolic anhydride pictures 2026-03-20 Diglycolic anhydride
4480-83-5
$10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
Diglycolic anhydride pictures 2025-05-26 Diglycolic anhydride
4480-83-5
$30.00 1kg 0.99 20 tons Hebei Fengjia New Material Co., Ltd
DIGLYCOLIC ANHYDRIDE DIGLYCOLIC ANHYDRIDE, TECH., 90% Diglycolicanhydride,95% Acetic acid, 2,2'-oxybis-, cyclic anhydride Acetic acid, oxydi-, cyclic anhydride Diglycolic acid anhydride Oxydiacetic anhydride p-Dioxane-2,6-dione 1,4-DIOXINE-2,6-DIONE Diglycolic anhydride,97% digylcolic anhydride Diglycolic anhydride, 97% 25GR 1,4-Dioxane-2,6-dione, 2,6-Dioxo-1,4-dioxane Diglycolic anhydride technical grade, 90% (R)-1-Methyl-2-pyrrolidineethanamine dihydrochloride 4-Maleimidobutyric acid hydrazide hydrochloride DiglycolicAnhydride> DIGLYCOLIC ANHYDRIDE FOR SYNTHESIS SKL267 Diglycolic anhydride (6CI) 1,4-DIOXANE-2,6-DIONE 4480-83-5 Dioxanes Dioxanes & Dioxolanes Organic Building Blocks Building Blocks Carbonyl Compounds Carboxylic Acid Anhydrides Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Dioxanes Dioxanes & Dioxolanes