4-(Boc-amino)cyclohexanecarboxylic acid
- CAS No.
- 130309-46-5
- Chemical Name:
- 4-(Boc-amino)cyclohexanecarboxylic acid
- Synonyms
- 4-(Boc-amino)cyclohexanecarboxylic acid;4-N-BOC-AMINOCYCLOHEXANE CARBOXYLIC ACID;4-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID;4-Aminocyclohexane-1-carboxylic acid, N-BOC protected;1-(t-Butyloxycarbonylamino)cyclohexyl-4-carboxylic acid;4-Aminocyclohexane-1-carboxylic acid, N-BOC protected 98%;4-[(tert-Butoxycarbonyl)amino]cyclohexane-1-carboxylic acid;4-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclohexanecarboxylic acid;Cyclohexanecarboxylicacid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-;4-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexane-1-carboxylic acid
- CBNumber:
- CB4369026
- Molecular Formula:
- C12H21NO4
- Molecular Weight:
- 243.3
- MDL Number:
- MFCD03453262
- MOL File:
- 130309-46-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2922498590 | |||||||||
| NFPA 704 |
|
4-(Boc-amino)cyclohexanecarboxylic acid price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B3248 | 4-(tert-Butoxycarbonylamino)cyclohexanecarboxylic Acid (cis- and trans- mixture) >98.0%(GC)(T) | 130309-46-5 | 5g | $83 | 2026-04-30 | Buy |
| TCI Chemical | B3248 | 4-(tert-Butoxycarbonylamino)cyclohexanecarboxylic Acid (cis- and trans- mixture) >98.0%(GC)(T) | 130309-46-5 | 25g | $275 | 2026-04-30 | Buy |
| Biosynth | FFA30946 | 4-(Boc-amino)cyclohexanecarboxylic acid | 130309-46-5 | 50g | $590 | 2026-06-04 | Buy |
| Apolloscientific | OR17545 | 4-Aminocyclohexane-1-carboxylic acid, N-BOC protected 97% | 130309-46-5 | 1g | $22 | 2026-06-04 | Buy |
| Apolloscientific | OR17545 | 4-Aminocyclohexane-1-carboxylic acid, N-BOC protected 97% | 130309-46-5 | 5g | $32 | 2026-06-04 | Buy |
4-(Boc-amino)cyclohexanecarboxylic acid Chemical Properties, Uses, Production
Uses
4-(Boc-amino)cyclohexanecarboxylic acid is used as pharmaceutical intermediate.
Synthesis
24424-99-5
1776-53-0
53292-90-3
To a stirred solution of trans-4-aminocyclohexanecarboxylic acid (1 g, 6.98 mmol) in tert-butanol (10 mL) and NaOH (0.307 g, 7.68 mmol) in water (10 mL) was slowly added di-tert-butyl dicarbonate (1.7 g, 7.68 mmol) at 0 °C. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, hexane (50 mL) was added to the mixture and the pH was adjusted to about 6 with 6 N HCl. Subsequently, the mixture was extracted with ethyl acetate (3 x 50 mL) and the organic phases were combined and washed with saturated brine solution (25 mL). The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the white powdery product cis-4-((tert-butoxycarbonyl)amino)cyclohexanecarboxylic acid (1.4 g, 82.8% yield). Mass spectrum (ES-) m/z 242 [M-H]-.
References
[1] Patent: US2017/348315, 2017, A1. Location in patent: Paragraph 0400
[2] Patent: WO2010/45987, 2010, A1. Location in patent: Page/Page column 43-44
[3] European Journal of Medicinal Chemistry, 2001, vol. 36, # 3, p. 265 - 286
[4] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 2, p. 89 - 93
4-(Boc-amino)cyclohexanecarboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
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