5-Bromo-3-iodo-1H-indazole
- CAS No.
- 459133-66-5
- Chemical Name:
- 5-Bromo-3-iodo-1H-indazole
- Synonyms
- 5-BROMO-3-IODOINDAZOLE;5-BROMO-3-IODO (1H)INDAZOLE;1H-Indazole, 5-broMo-3-iodo--;1H-Indazole, 5-broMo-3-iodo--3
- CBNumber:
- CB4389097
- Molecular Formula:
- C7H4BrIN2
- Molecular Weight:
- 322.93
- MDL Number:
- MFCD07781637
- MOL File:
- 459133-66-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 196 °C(Solv: ligroine (8032-32-4)) |
|---|---|
| Boiling point | 413.1±25.0 °C(Predicted) |
| Density | 2.421±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 10.78±0.40(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C7H4BrIN2/c8-4-1-2-6-5(3-4)7(9)11-10-6/h1-3H,(H,10,11) |
| InChIKey | IBFAYUXCRDDBRD-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(Br)C=C2)C(I)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P260-P280-P301+P312-P302+P352-P304+P340-P361+P364 |
| RIDADR | UN2811 |
| HS Code | 2933998090 |
5-Bromo-3-iodo-1H-indazole price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 266260 | 5-Bromo-3-iodo indazole Asreported | 459133-66-5 | 250mg | $368 | 2026-06-03 | Buy |
| Usbiological | 266260 | 5-Bromo-3-iodo indazole Asreported | 459133-66-5 | 500mg | $509 | 2026-06-03 | Buy |
| Usbiological | 266260 | 5-Bromo-3-iodo indazole Asreported | 459133-66-5 | 1g | $844 | 2026-06-03 | Buy |
| Usbiological | 266260 | 5-Bromo-3-iodo indazole Asreported | 459133-66-5 | 2g | $1187 | 2026-06-03 | Buy |
| Usbiological | 266260 | 5-Bromo-3-iodo indazole Asreported | 459133-66-5 | 5g | $1693 | 2026-06-03 | Buy |
5-Bromo-3-iodo-1H-indazole Chemical Properties, Uses, Production
Uses
5-Bromo-3-iodo-1H-indazole is important chemical intermediate.
Synthesis
53857-57-1
459133-66-5
General procedure for the synthesis of 5-bromo-3-iodo-1H-indazole from 5-bromo-1H-indazole: To a solution of 5-bromo-1H-indazole (5.0 g, 25.4 mmol, 1.0 eq.) in anhydrous DMF (15.0 mL) was added sequentially, protected by nitrogen, KOH (4.3 g, 76.1 mmol, 3.0 eq.) and iodine (12.9 g, 50.75 mmol, 2.0 equiv). The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction solution was diluted with ice water and then extracted with ethyl acetate (50 mL x 2). The organic layers were combined, washed sequentially with aqueous Na2S2O3 and brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure to afford the crude product 5-bromo-3-iodo-1H-indazole (8.0 g, 97.9% yield), which could be used for the next reaction without further purification.
References
[1] Molecules, 2018, vol. 23, # 8,
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 6, p. 2361 - 2372
[3] Patent: WO2017/98328, 2017, A2. Location in patent: Paragraph 00213
[4] Synthesis, 2006, # 20, p. 3506 - 3514
[5] Letters in Drug Design and Discovery, 2013, vol. 10, # 7, p. 625 - 631
5-Bromo-3-iodo-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xuchang Fengfei New Materials Technology Co., Ltd | 19713077352; 19713077352 | 1038096457@qq.com | China | 2330 | 58 |
| Shenzhen Gre-syn Chemical Technology Co., Ltd. | 13226079980 | 761330897@qq.com | China | 1159 | 55 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| skychemical Co.Ltd | 021-20958197 20965099 | sales@skychemical.com | China | 1182 | 57 |
View Latest Price from 5-Bromo-3-iodo-1H-indazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 5-BROMO-3-IODO (1H)INDAZOLE
459133-66-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 5-BROMO-3-IODO (1H)INDAZOLE
459133-66-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-03 | 5-BROMO-3-IODO (1H)INDAZOLE
459133-66-5
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- 5-BROMO-3-IODO (1H)INDAZOLE
459133-66-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-BROMO-3-IODO (1H)INDAZOLE
459133-66-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-BROMO-3-IODO (1H)INDAZOLE
459133-66-5
- $1.00
- 95-99%
- Career Henan Chemical Co
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