3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 96551-22-3
- Chemical Name:
- 3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- TERT-BUTYL 3-(HYDROXYMETHYL)-1H-INDOLE-1-CARBOXYLATE;Ethanol,7-diazenyl-;Benzene,1-ethenyl-6-nitro-;1-BOC-3-HYDROXYMETHYL-INDOLE;N-BOC-3-(HYDROXYMETHYL)INDOLE;3-(Hydroxymethyl)indole, N-BOC;3-(HYDROXYMETHYL)INDOLE, N-BOC PROTECTED;3-(HYDROXYMETHYL)-1H-INDOLE-1-CARBOXYLATE;t-butyl 3-hydroxymethylindole-1-carboxylate;3-(Hydroxymethyl)-1H-indole, N-BOC protected
- CBNumber:
- CB4401612
- Molecular Formula:
- C14H17NO3
- Molecular Weight:
- 247.29
- MDL Number:
- MFCD05864717
- MOL File:
- 96551-22-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Hydroxymethylindole-1-carboxylic acid tert-butyl ester Asreported | 280130 | 1g | $333 |
| 3-Hydroxymethylindole-1-carboxylic acid tert-butyl ester Asreported | 280130 | 2g | $463 |
| 3-Hydroxymethylindole-1-carboxylic acid tert-butyl ester Asreported | 280130 | 5g | $622 |
| 3-Hydroxymethylindole-1-carboxylic acid tert-butyl ester Asreported | 280130 | 10g | $831 |
| 3-Hydroxymethylindole-1-carboxylic acid tert-butyl ester ≥95% | 17590 | 1G | $60.39 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 280130 | 3-Hydroxymethylindole-1-carboxylic acid tert-butyl ester Asreported | 96551-22-3 | 1g | $333 | 2026-06-03 | Buy |
| Usbiological | 280130 | 3-Hydroxymethylindole-1-carboxylic acid tert-butyl ester Asreported | 96551-22-3 | 2g | $463 | 2026-06-03 | Buy |
| Usbiological | 280130 | 3-Hydroxymethylindole-1-carboxylic acid tert-butyl ester Asreported | 96551-22-3 | 5g | $622 | 2026-06-03 | Buy |
| Usbiological | 280130 | 3-Hydroxymethylindole-1-carboxylic acid tert-butyl ester Asreported | 96551-22-3 | 10g | $831 | 2026-06-03 | Buy |
| Chem-Impex | 17590 | 3-Hydroxymethylindole-1-carboxylic acid tert-butyl ester ≥95% | 96551-22-3 | 1G | $60.39 | 2026-05-19 | Buy |
3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production
Chemical Properties
3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is Light Brown Solid
Uses
3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER can be used in the preparation of arylpiperidinones for treatment of inflammation.
Synthesis
57476-50-3
96551-22-3
Step 2. To a solution of tert-butyl 3-formyl-1H-indole-1-carboxylate (44 g, 0.17 mol) in anhydrous ethanol (50 mL) was added sodium borohydride (16.6 g, 0.45 mol) in batches at 0 °C. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was filtered to remove insoluble material. The filtrate was rotary evaporated to remove ethanol. The residue was dissolved in ethyl acetate (100 mL) and water (50 mL) for partitioning. The aqueous layer was further extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with saturated saline (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give tert-butyl 3-(hydroxymethyl)-1H-indole-1-carboxylate (40 g, 95% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 1.59 (s, 9H), 4.77 (s, 2H), 7.19 (t, 1H), 7.25 (t, 1H), 7.51 (s, 1H), 7.57 (d, 1H), 8.06 (d, 1H).
References
[1] Liebigs Annalen der Chemie, 1985, # 2, p. 413 - 417
[2] Journal of Organic Chemistry, 2016, vol. 81, # 4, p. 1723 - 1730
[3] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 8, p. 1242 - 1247
[4] Patent: WO2013/148365, 2013, A1. Location in patent: Paragraph 0083
[5] Synthetic Communications, 2000, vol. 30, # 12, p. 2143 - 2159
3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Shanghai Safer Pharmaceutical Technology Co., Ltd. | 021-31761238 | sales@saferph.com | CHINA | 897 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 17259 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4871 | 58 |
View Lastest Price from 3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | 1-Boc-3-Hydroxymethylindole
96551-22-3
|
$2.00 | 1KG | ≥98% | 100kg | Career Henan Chemical Co |
-
- 1-Boc-3-Hydroxymethylindole
96551-22-3
- $2.00
- ≥98%
- Career Henan Chemical Co
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