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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide structure

CAS No.: 1892-57-5

Chemical Name:: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

Synonyms: EDCI;EDAC;1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE;WSCI;WSCD;N1-((EthyliMino)Methylene)-N3,N3-diMethylpropane-1,3-diaMine;({[3-(dimethylamino)propyl]imino}methylidene)(ethyl)amine;1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide;1-(3-Dimethylaminopropyl)-3-;WATER-SOLUBLE CARBODIIMIDE

CBNumber:: CB4403030

Molecular Formula:: C8H17N3

Molecular Weight:: 155.24

MDL Number:: MFCD00044916

MOL File:: 1892-57-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:27:50

Product description	Number	Pack Size	Price
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide ≥97.0% (T)	39391	10ml	$204
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide ≥97.0% (T)	39391	50ml	$876
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide >98.0%(GC)(T)	D4029	5g	$80
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide >98.0%(GC)(T)	D4029	25g	$240
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide	TRC-D460818-50MG	50mg	$64
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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Properties

Boiling point	66-68°C/1mm
Density	0.877 g/mL at 20 °C (lit.)
refractive index	n20/D 1.461
Flash point	66-68°C/1mm
storage temp.	-20°C
solubility	Chloroform
pka	9.52±0.28(Predicted)
form	Liquid
Specific Gravity	0.885
color	Colorless to slightly yellow
Water Solubility	Soluble in water.
Sensitive	Air Sensitive
BRN	507429
Major Application	peptide synthesis
InChI	1S/C8H17N3/c1-4-9-8-10-6-5-7-11(2)3/h4-7H2,1-3H3
InChIKey	LMDZBCPBFSXMTL-UHFFFAOYSA-N
SMILES	CCN=C=NCCCN(C)C
CAS DataBase Reference	1892-57-5(CAS DataBase Reference)
FDA UNII	RJ5OZG6I4A
NIST Chemistry Reference	1,3-Propanediamine, n'-(ethylcarbonimidoyl)-n,n-dimethyl-(1892-57-5)
EPA Substance Registry System	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl- (1892-57-5)
UNSPSC Code	12352116
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08,GHS09

Signal word

Danger

Hazard statements

H302-H311-H315-H317-H373-H410

Precautionary statements

P260-P273-P280-P301+P312-P302+P352+P312-P314

target organs

Stomach,large intestine,lymph node

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

Safety Statements

26-36/37/39-45

RIDADR

UN 2735 8/PG 3

WGK Germany

1-3-10

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29252900

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 3 Dermal
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Dam. 1
Skin Corr. 1A
Skin Sens. 1A
STOT RE 2 Oral

NFPA 704

	1
3		1

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	39391	N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide ≥97.0% (T)	1892-57-5	10ml	$204	2026-04-30	Buy
Sigma-Aldrich	39391	N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide ≥97.0% (T)	1892-57-5	50ml	$876	2026-04-30	Buy
TCI Chemical	D4029	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide >98.0%(GC)(T)	1892-57-5	5g	$80	2026-04-30	Buy
TCI Chemical	D4029	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide >98.0%(GC)(T)	1892-57-5	25g	$240	2026-04-30	Buy
TRC	TRC-D460818-50MG	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide	1892-57-5	50mg	$64	2026-06-03	Buy

Product number	Packaging	Price	Buy
39391	10ml	$204	Buy
39391	50ml	$876	Buy
D4029	5g	$80	Buy
D4029	25g	$240	Buy
TRC-D460818-50MG	50mg	$64	Buy

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Chemical Properties,Uses,Production

Description

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is a water-soluble carbodiimide available as hydrochloride salt. This compound is a carboxyl- and amine-reactive crosslinker that is water soluble and can activate carboxyl residues for their reaction with primary amines to form O-acylisourea as a reaction intermediate, which reacts with amide bonds to release isourea as a by-product. It can crosslink the carboxy-group of glutamate and aspartate to the side-chain primary amine of lysine and the amino group at the N-terminus. The crosslinker readily reacts at a pH range of 4.5–7.2 and only crosslinks the residues within their van der Waals distance. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is also widely used in fabricating different nanosystems implemented in drug/protein delivery systems. It is mainly used for surface crosslinking/immobilization of drugs to increase stability against environmental changes, such as pH or temperature[1-2].

Chemical Properties

Clear light yellow liquid

Uses

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is used as a carboxyl activating agent and activate phosphate groups in phospho mono and di esters. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.

General Description

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is commonly used in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reaction to activate carboxyl group for coupling with amines to form amides.

reaction suitability

reaction type: Coupling Reactions

Synthesis

The production method of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide is to react with N, N'-dimethylpropanediamine and carbon disulfide as raw materials to prepare N, N'- Dimethylpropylthiourea. Then it is oxidized with ethyl chloroformate to obtain N, N'-dimethylpropyl isothiocyanate, which is then reacted with ethylamine and oxidized with sodium hypochlorite to obtain the product 1-(3-dimethylaminopropyl)-3- Ethylcarbodiimide.
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

References

[1] Manjula ;Mummadisetti et al.“Chapter Five-An approach to nearest neighbor analysis of pigment-protein complexes using chemical cross-linking in combination with mass spectrometry.” Methods in enzymology" Methods in Enzymology, 680 (2023) 139-162.
[2] Dmour, Isra and M. Taha. “Natural and semisynthetic polymers in pharmaceutical nanotechnology.”Organic Materials as Smart Nanocarriers for Drug Delivery (2018) 35-100.

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide synthesis

Synthesis of 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide from 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Preparation Products And Raw materials

Raw materials

Ethyl isocyanate 3-Dimethylaminopropylamine Potassium carbonate Triethylamine Tosyl chloride

Diethyl ether Dichloromethane

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Preparation Products

N-Succinimidyl Methacrylate 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Suppliers

Global( 391)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14036	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759	marketing1@neostarunited.com	China	8827	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34526	58
AFINE CHEMICALS LIMITED	+86-571-85134551 +86-18958018566	info@afinechem.com	China	15052	58
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9539	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
AFINE CHEMICALS LIMITED	58
Finetech Industry Limited	58

View Lastest Price from 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-24	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5		1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-20	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5	$10.00	100KG	99%	100 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-06-20	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5	$9.00-30.00	1kg	0.99	10 tons	Hebei Yanxi Chemical Co., Ltd.

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
1892-57-5
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
1892-57-5
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
1892-57-5
$9.00-30.00
0.99
Hebei Yanxi Chemical Co., Ltd.

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Spectrum

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide(1892-57-5)¹HNMR

1892-57-5(1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide)Related Search:

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Ethyl formate ISOXADIFEN-ETHYL N,N'-Diisopropylcarbodiimide 4-Dimethylaminobenzoic acid Ethylparaben

Ethyl acetate Ethyl acrylate N,N-Diisopropylethylamine Ethanol N,N-Dimethylformamide

Phthalimide Ethyl cyanoacetate 4-Dimethylaminobenzaldehyde

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1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE WSCD N-ETHYL-N'-(3-DIMETHYLAMINOPROPYL)CARBODIIMIDE ethyldimethylaminopropylcarbodiimide n’-(ethylcarbonimidoyl)-n,n-dimethyl-3-propanediamine N3-Ethyliminomethylene-N1,N1-dimethylpropane-1,3-diamine 1-(3-dimethylaminopropyl)-N?ethylcarbodiimide N'-(ethylcarbonimidoyl)-N,N-dimethylpropane-1,3-diamine Rivaroxaban Impurity 139 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 98% EDC polymer-bound, N-Ethyl-Nμ-(3-dimethylaminopropyl)carbodiimide polymer-bound, N-(3-Dimethylaminopropyl)-Nμ-ethylcarbodiimide polymer-bound EDC, WSC, N-Ethyl-Nμ-(3-dimethylaminopropyl)carbodiimide 1-ehyl-3-(dimethylaminopropyl)carbodiimide 3-[(Ethylcarbonimidoyl)amino]-N,N-dimethyl-1-propanamine WSC【Dotite】 3-(ethyliminomethyleneamino)propyl-dimethyl-amine 3-(ethyliminomethylideneamino)-N,N-dimethyl-propan-1-amine 3-(ethyliminomethylideneamino)-N,N-dimethylpropan-1-amine N-(3-Dimethylaminopr N-(3-DiMethylaMinopropyl)-N'-ethylcarb N-(3-DiMethylaMinopropyl)-N'-ethylcarbodiiMide(EDCI) N-(3-DiMethylaMinopropyl)-N'-ethylcarbodiiMide >=97.0% (T) 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide EDC EDAC 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide(EDC) 1-(3-Dimethylaminopropyl)-3- 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 97%, for synthesis 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide> 1,3-Propanediamine, N3-(ethylcarbonimidoyl)-N1,N1-dimethyl- N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide, ≥97% Avanafil Impurity 72 1-ETHYL-(3- DIMETHYLAMINOPROPYL)CARBODIIMIDE (EDC Free Base) 1-(3-Dimethylaminopropyl)-3- ethylcarb n'-(ethylkohlenstoffimidoyl)-n,n-dimethylpropan-1,3-diamin N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide 98% N'-(Ethylkohlenstoffimidoyl)-N,N-dimethylpropan-1,3-diamin Rivaroxaban Impurity 139 (Mirabegron EP Impurity I) 1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE WATER-SOLUBLE CARBODIIMIDE WSCI [3-(Dimethylamino)propyl]ethylcarbodiimide EDCI ({[3-(dimethylamino)propyl]imino}methylidene)(ethyl)amine 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide EDAC N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide N1-((EthyliMino)Methylene)-N3,N3-diMethylpropane-1,3-diaMine Mirabegron Impurity 142 1892-57-5 25952-83-0 CH3CH2NCNCH23NCH32 C8H17N3 BioChemical Carbodiimides Reagents for Protein Sequencing Protein Sequencing Protein Analysis Proteomics and Protein Expression