Dihydrocoumarin
- CAS No.
- 119-84-6
- Chemical Name:
- Dihydrocoumarin
- Synonyms
- 3,4-DIHYDROCOUMARIN;HYDROCOUMARIN;CHROMAN-2-ONE;3,4-DIHYDRO-2H-1-BENZOPYRAN-2-ONE;FEMA 2381;MELILOTIN;2-Chromanone;BENZODIHYDROPYRONE;2H-1-Benzopyran-2-one, 3,4-dihydro-;3,4-Dihydro-1-benzopyran-2-one
- CBNumber:
- CB4413174
- Molecular Formula:
- C9H8O2
- Molecular Weight:
- 148.16
- MDL Number:
- MFCD00006881
- MOL File:
- 119-84-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 24-25 °C (lit.) |
|---|---|
| Boiling point | 272 °C (lit.) |
| Density | 1.169 g/mL at 25 °C (lit.) |
| vapor pressure | 13.6kPa at 20℃ |
| FEMA | 2381 | DIHYDROCOUMARIN |
| refractive index |
n |
| FLAVIS Number | 13.009 | 3,4-Dihydrocoumarin |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform, Methanol (Sparingly) |
| form | Solid |
| color | Colourless to Off-White |
| Specific Gravity | 1.169 |
| Odor | at 10.00 % in dipropylene glycol. sweet tonka coumarinic coconut herbal cinnamon balsamic |
| Odor Type | tonka |
| biological source | synthetic |
| Water Solubility | insoluble |
| JECFA Number | 1171 |
| BRN | 4584 |
| Cosmetics Ingredients Functions |
FRAGRANCE PERFUMING |
| InChI | 1S/C9H8O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2 |
| InChIKey | VMUXSMXIQBNMGZ-UHFFFAOYSA-N |
| SMILES | O=C1CCc2ccccc2O1 |
| LogP | 1.82 at 25℃ |
| Toxicology and Carcinogenesis | Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CASRN 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) |
| Substances Added to Food (formerly EAFUS) | DIHYDROCOUMARIN |
| CAS DataBase Reference | 119-84-6(CAS DataBase Reference) |
| EWG's Food Scores | 4-7 |
| FDA UNII | NM5K1Y1BT2 |
| NIST Chemistry Reference | 2H-1-Benzopyran-2-one, 3,4-dihydro-(119-84-6) |
| EPA Substance Registry System | 3,4-Dihydrocoumarin (119-84-6) |
| UNSPSC Code | 12352200 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317 | |||||||||
| Precautionary statements | P261-P264-P270-P280-P301+P312-P302+P352 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MW5775000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29322980 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Skin Sens. 1 |
|||||||||
| Hazardous Substances Data | 119-84-6(Hazardous Substances Data) | |||||||||
| Toxicity | The acute oral LD50 value in rats was reported as 1.65 g/kg (1.47-1.83 g/ kg) (Moreno, 1972a). The acute dermal LD50 value in rabbits was reported as > 5 g/kg (Moreno, 1972b). | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Dihydrocoumarin price More Price(94)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W238104 | Dihydrocoumarin ≥99%, FCC, FG | 119-84-6 | 1 each | $58 | 2026-04-30 | Buy |
| Sigma-Aldrich | W238104 | Dihydrocoumarin ≥99%, FCC, FG | 119-84-6 | 1kg | $86 | 2026-04-30 | Buy |
| Sigma-Aldrich | W238104 | Dihydrocoumarin ≥99%, FCC, FG | 119-84-6 | 5kg | $229 | 2026-04-30 | Buy |
| Sigma-Aldrich | W238104 | Dihydrocoumarin ≥99%, FCC, FG | 119-84-6 | 10Kg | $383 | 2026-04-30 | Buy |
| Sigma-Aldrich | D104809 | Dihydrocoumarin 99% | 119-84-6 | 5g | $39.9 | 2026-04-30 | Buy |
Dihydrocoumarin Chemical Properties,Uses,Production
Description
With a sweet, creamy, and herbal, fragrance, with a slightly burnt taste, dihydrocoumarin (DHC) is used as a flavoring agent in food, tobacco, soap, and perfume, etc. Its exotic flavor is well suited for caramel, nuts, dairy, vanilla, tropical fruit, and alcohol. It is a eukaryotic metabolite found in tonka beans grown in northern South America, from which it was isolated as early as the 1820s, as well as sweet clover. Other uses include as an organic solvent and pharmaceutical intermediary. It has been shown to influence the epigenetic process of human cells in vitro.
Sources
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16151
http://www.bojensen.net/EssentialOilsEng/EssentialOils29/EssentialOils29.htm#Tonka
https://books.google.kg/books?id=pUEqBgAAQBAJ&pg=PA427&lpg=PA427&dq=dihydrocoumarin+uses&source=bl&ots=HTZrffvsXu&sig=GPGKqrMRXQaRJ-qgHk7aULeBmGw&hl=en&sa=X&redir_esc=y#v=onepage&q=dihydrocoumarin%20uses&f=false
https://products.symrise.com/aroma-molecules/product-search/dihydrocoumarin/action/pdf/
http://www.lookchem.com/3-4-Dihydrocoumarin/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315280/
Chemical Properties
Dihydrocoumarin forms colorless crystals (mp 24°C) with a sweet, herbal odor. Dihydrocoumarin is prepared by hydrogenation of coumarin, for example, in the presence of a Raney nickel catalyst. Another process employs the vapor-phase dehydrogenation of hexahydrocoumarin in the presence of Pd or Pt-Al2O3 catalysts . Hexahydrocoumarin is prepared by cyanoethylation of cyclohexanone and hydrolysis of the nitrile group, followed by ring closure to the lactone.
Chemical Properties
Dihydrocoumarin has an odor similar to coumarin at room temperature or reminiscent of nitrobenzene at higher temperature. It has a burning taste.
Occurrence
Reported found in Melilotus officinalis, from which it may be extracted by water distillation.
Uses
Hydrocoumarin can be used as a reagent to prepare splitomicin analogs as inhibitors of Sir2.
Uses
Dihydrocoumarin may be used as an analytical reference standard for the determination of the analyte in guaco extracts and pharmaceutical preparations, and various plant extracts by chromatography-based techniques and capillary electrophoresis.
Definition
ChEBI: A chromanone that is the 3,4-dihydro derivative of coumarin.
Preparation
Dihydrocoumarin is synthesized by reduction of coumarin under pressure in the presence of nickel at 160 to 200°C or in the presence of Pd-BaSO4 in alcoholic solution.
Synthesis Reference(s)
Tetrahedron Letters, 37, p. 4555, 1996 DOI: 10.1016/0040-4039(96)00902-1
General Description
Viscous, almost colorless liquid, solidifying
in the cold, melting at 23° C. Sp. Gr. 1.19.
B.P. 272° C.
Slightly soluble in water, soluble in alcohol,
miscible with oils.
Sweet-herbaceous, nutlike, haylike odor,
usually described as "coumannic" or "tobacco-like".
Air & Water Reactions
Solutions of the chemical in water are stable for less than two hours. Insoluble in water.
Reactivity Profile
Hydrocoumarin is a lactone (behaves as an ester). Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Hydrocoumarin may hydrolyze under alkaline or acidic conditions.
Fire Hazard
Hydrocoumarin is combustible.
Biochem/physiol Actions
Taste at 10 ppm
Dihydrocoumarin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| jiliang chemicals | 21-62165282 | bidingchem@163.com | China | 1395 | 60 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 |
Related articles
- Dihydrocoumarin: An HDAC Inhibitor with Implications for DNA Repair, Aging, and One - Pot Synthesis
- Dihydrocoumarin is a compound in Melilotus officinalis and a flavoring agent that inhibits the NAD-dependent histone deacetyla....
- Apr 17,2025
View Lastest Price from Dihydrocoumarin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-17 | Dihydrocoumarin
119-84-6
|
$29.00 | 99.19% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-28 | Dihydrocoumarin
119-84-6
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | Cinnamic acid
119-84-6
|
$10.00 | 1KG | 99% | 5tons | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Dihydrocoumarin
119-84-6
- $29.00
- 99.19%
- TargetMol Chemicals Inc.
-
- Dihydrocoumarin
119-84-6
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Cinnamic acid
119-84-6
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
