4-(4-Methylpiperazino)benzylamine
- CAS No.
- 216144-45-5
- Chemical Name:
- 4-(4-Methylpiperazino)benzylamine
- Synonyms
- AKOS B022037;BUTTPARK 98\50-54;ART-CHEM-BB B022037;4-(4-Methylpiperazino)benzylam;4-(4-Methylpiperazin-1-yl)Benz;4-(4-METHYLPIPERAZINO)BENZYLAMINE;4-(4-Methylpiperazino)benzylamine90%;4-(4-Methylpiperazino)benzylamine 90%;4-(4-Methylpiperazin-1-yl)benzylamine;4-(4-Methyl-1-piperazinyl)benzylamine
- CBNumber:
- CB4420929
- Molecular Formula:
- C12H19N3
- Molecular Weight:
- 205.3
- MDL Number:
- MFCD03086117
- MOL File:
- 216144-45-5.mol
- MSDS File:
- SDS
| Boiling point | 122-124/0.05mm |
|---|---|
| Density | 1.065±0.06 g/cm3(Predicted) |
| storage temp. | Store at Room Tem. |
| pka | 10.40±0.10(Predicted) |
| CAS DataBase Reference | 216144-45-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Hazard Codes | C |
| Risk Statements | 36/37/38-34 |
| Safety Statements | 26-36/37/39-45 |
| Hazard Note | Corrosive |
| HS Code | 2933599590 |
4-(4-Methylpiperazino)benzylamine price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 50202 | (4-(4-METHYLPIPERAZIN-1-YL)-BENZYLAMINE 95% | 216144-45-5 | 1G | $77 | 2026-04-30 | Buy |
| AstaTech | 50202 | (4-(4-METHYLPIPERAZIN-1-YL)-BENZYLAMINE 95% | 216144-45-5 | 5G | $195 | 2026-04-30 | Buy |
| Activate Scientific | AS22735 | 4-(4-Methylpiperazino)benzylamine 98% | 216144-45-5 | 1g | $78 | 2026-06-04 | Buy |
| Activate Scientific | AS22735 | 4-(4-Methylpiperazino)benzylamine 98% | 216144-45-5 | 5g | $304 | 2026-06-04 | Buy |
| Apolloscientific | OR23311 | 4-(4-Methylpiperazin-1-yl)benzylamine 95% | 216144-45-5 | 5g | $191 | 2026-06-04 | Buy |
4-(4-Methylpiperazino)benzylamine Chemical Properties, Uses, Production
Synthesis
34334-28-6
216144-45-5
General procedure for the synthesis of 4-(4-methyl-1-piperazinyl)benzylamine from 4-(4-methylpiperazin-1-yl)benzonitrile: Sodium borohydride (10 eq.) was added to a solution of 4-(4-methylpiperazin-1-yl)benzonitrile (1 eq.) and cobalt chloride hexahydrate (2.1 eq.). The reaction mixture was stirred for 5 hours and then filtered through a pad of diatomaceous earth. The organic phase was concentrated under reduced pressure. The yellow oil obtained was purified by rapid chromatography on silica gel (dichloromethane: methanol = 8:2) to afford the target compound 4-(4-methyl-1-piperazinyl)benzylamine as a white solid in 50% yield.1H NMR (400 MHz, methanol-d4): δ (ppm) 2.42 (s, 3H); 2.74 (t, J=8Hz, 4H); 3.17 (t. J=8Hz, 4H); 4.43 (s, 2H); 6.89 (d, J=8Hz, 2H); 7.18 (d, J=8Hz, 2H). Elemental analysis (C12H19N3) calculated values: C, 70.20; H, 9.33; N, 20.47; measured values: C, 70.10; H, 9.13; N, 20.27.
References
[1] Tetrahedron Letters, 2013, vol. 54, # 38, p. 5204 - 5206
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 26, p. 8261 - 8269
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5293 - 5305
[4] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 7, p. 741 - 745
4-(4-Methylpiperazino)benzylamine Preparation Products And Raw materials
4-(4-Methylpiperazino)benzylamine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Record Tech (Shanghai) Co., LTD | 13761627472 | 183009664@qq.com | China | 659 | 62 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
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| Suzhou Sibian Chemical Technology Co.,Ltd. | 0512-65617459 18915409046 | sales@sibian-chem.com | China | 1917 | 55 |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824; | bjkaida@163.com | China | 1597 | 59 |
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