β-Boswellic Acid
- CAS No.
- 631-69-6
- Chemical Name:
- β-Boswellic Acid
- Synonyms
- BETA-BOSWELLIC ACID;BRN0077366;Masticinic acid;Frankincic acid;B-BOSWELLIC ACID;β-Boswellic Acid;BOSWELLIC ACID, B-;BOSWELLIC ACID, a-(P);BOSWELLIC ACID B-(P) 25mg;β-Boswellic Acid USP/EP/BP
- CBNumber:
- CB4427357
- Molecular Formula:
- C30H48O3
- Molecular Weight:
- 456.71
- MDL Number:
- MFCD04039448
- MOL File:
- 631-69-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 130-135°C |
|---|---|
| alpha | D +107° (c = 0.75 in CHCl3) |
| Boiling point | 556.0±50.0 °C(Predicted) |
| Density | 1.09±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.50±0.70(Predicted) |
| color | Off-White |
| Water Solubility | practically insoluble in water |
| Major Application | food and beverages |
| InChIKey | NBGQZFQREPIKMG-AKOQEMLPSA-N |
| SMILES | C[C@@H]1CC[C@]2(C)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@@H](O)[C@@](C)([C@@H]5CC[C@@]34C)C(O)=O)[C@@H]2[C@H]1C |
| LogP | 9.105 (est) |
| CAS DataBase Reference | 631-69-6 |
| FDA UNII | B252M1YO2V |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
β-Boswellic Acid price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89454 | β-Boswellic acid phyproof® Reference Substance | 631-69-6 | 10 mg | $662 | 2026-04-30 | Buy |
| Sigma-Aldrich | 80342 | β-Boswellic acid analytical standard | 631-69-6 | 5mg | $608 | 2026-04-30 | Buy |
| Cayman Chemical | 11693 | β-Boswellic Acid ≥95% | 631-69-6 | 1mg | $60 | 2026-04-30 | Buy |
| Cayman Chemical | 11693 | β-Boswellic Acid ≥95% | 631-69-6 | 5mg | $208 | 2026-04-30 | Buy |
| Cayman Chemical | 11693 | β-Boswellic Acid ≥95% | 631-69-6 | 10mg | $357 | 2026-04-30 | Buy |
β-Boswellic Acid Chemical Properties, Uses, Production
Description
β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities. It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 μM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid . It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 μM for DNA, RNA, and protein synthesis, respectively. In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS). It also increases calcium mobilization in platelets at concentrations ≥3 μM and induces platelet aggregation (EC50 = 8 μM).
Chemical Properties
BETA-BOSWELLIC ACID is Off-White Solid
Uses
The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
Definition
ChEBI: Boswellic acid is a triterpenoid.
Anticancer Research
It is a natural pentacyclic triterpenediol and occurs in Boswellia serrata plants as anisomeric blend of 3α, 24-dihydroxyolean-12-ene and 3α, 24-dihydroxyurs-12-ene.It induces apoptosis in various cancer cells. The events involved in this process areexcessive reactive oxygen species (ROS), nitric oxide (NO) formation, DNA ladderformation, and increased sub-G0 phase in cell cycle. This ultimately results incleavage of Bcl-2 and translocation of Bax to mitochondria, which lead to the lossof mitochondrial potential and release of cyt-c and other factors into cytosol. All these events are linked with reduced expression of survivin and inhibitor of caspase-activatedDNases (ICAD) that leads to the activation of poly(ADP-ribose) polymerase(PARP). The triterpene upregulates the expression of cell death receptor-4(DR-4) and tumor necrosis factor receptor-1 (TNF-R1), where both lead to activationof caspase-8 (Huang et al. 2000; Desai et al. 2008; Lu et al. 2008).
References
[1] H.P.T. AMMON. Mechanism of antiinflammatory actions of curcumine and boswellic acids[J]. Journal of ethnopharmacology, 1993, 38 2: Pages 105-112. DOI: 10.1016/0378-8741(93)90005-p
[2] H SAFAYHI. Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.[J]. Journal of Pharmacology and Experimental Therapeutics, 1992, 261 3: 1143-1146.
[3] Y SHAO. Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture.[J]. Planta medica, 1998, 64 4: 328-331. DOI: 10.1055/s-2006-957444
[4] MINGMING WANG. Pretreatment with β-Boswellic Acid Improves Blood Stasis Induced Endothelial Dysfunction: Role of eNOS Activation.[J]. Scientific Reports, 2015: 15357. DOI: 10.1038/srep15357
[5] ULF SIEMONEIT. Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts.[J]. Planta medica, 2017, 83 12-13: 1020-1027. DOI: 10.1055/s-0043-107884
β-Boswellic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xian JCF Herb Technology Development Co., Ltd | 18149239207 13679125026 | 769591166@qq.com | China | 1003 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
View Latest Price from β-Boswellic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | β-Boswellic Acid
631-69-6
|
1KG | >99% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | ||
 |
2026-06-30 | β-Boswellic Acid
631-69-6
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-22 | β-Boswellic Acid
631-69-6
|
1kg | 65% 90% | 1000 kg | BINBOBIO CO., LTD. |
-
- β-Boswellic Acid
631-69-6
- $0.00
- >99% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- β-Boswellic Acid
631-69-6
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- β-Boswellic Acid
631-69-6
- $0.00
- 65% 90%
- BINBOBIO CO., LTD.
