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2-Acetylthiophene

2-Acetylthiophene Structure
2-Acetylthiophene structure
CAS No.
88-15-3
Chemical Name:
2-Acetylthiophene
Synonyms
Ethanone, 1-(2-thienyl)-;AKOS 91936;2-Acetylthioph;2-Acetothienone;2-Acetylthiophen;2-ACETYLTHIOLE;2-Acylthiophene;2-ACETOTHIOPHENE;-Acetylthiophene;2-ACETYLTHIOPHENE
CBNumber:
CB5259889
Molecular Formula:
C6H6OS
Molecular Weight:
126.18
MDL Number:
MFCD00005442
MOL File:
88-15-3.mol
MSDS File:
SDS
Last updated:2026-01-13 11:21:33
Product description Number Pack Size Price
2-Acetylthiophene 98% A22602 25g $38
2-Acetylthiophene ≥98%, FG W503509 250g $173
2-Acetylthiophene ≥98%, FG W503509 1kg $521
2-Acetylthiophene for synthesis 8.00175 50mL $110
2-Acetylthiophene for synthesis 8.00175 250ML $450
More product size
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2-Acetylthiophene Properties

Melting point 10-11 °C (lit.)
Boiling point 214 °C (lit.)
Density 1.168 g/mL at 25 °C (lit.)
vapor pressure 2.7 hPa (50 °C)
refractive index n20/D 1.565(lit.)
Flash point 196 °F
storage temp. Store below +30°C.
solubility 14g/l
form Liquid
color Clear pale yellow to light brown
Odor at 100.00 %. sulfurous nutty hazelnut walnut
Odor Type sulfurous
biological source synthetic
Water Solubility Insoluble in water.
Sensitive Light Sensitive
BRN 107910
Major Application flavors and fragrances
InChI 1S/C6H6OS/c1-5(7)6-3-2-4-8-6/h2-4H,1H3
InChIKey WYJOVVXUZNRJQY-UHFFFAOYSA-N
SMILES CC(=O)c1cccs1
LogP 1.250
CAS DataBase Reference 88-15-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 5ASO208T20
NIST Chemistry Reference Ethanone, 1-(2-thienyl)-(88-15-3)
EPA Substance Registry System Ethanone, 1-(2-thienyl)- (88-15-3)
UNSPSC Code 12352115
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300+H330-H311
Precautionary statements  P260-P264-P270-P280-P302+P352+P312-P304+P340+P310
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  T,Xi,Xn
Risk Statements  25-23/24/25-20/21/22
Safety Statements  45-38-36/37/39-28-36
RIDADR  UN 2810 6.1/PG 2
WGK Germany  3
RTECS  OB6300000
F  13
Autoignition Temperature 265 °C DIN 51794
Hazard Note  Irritant
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  II
HS Code  29349990
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 2 Inhalation
Acute Tox. 2 Oral
Acute Tox. 3 Dermal
Toxicity LD50 orally in Rabbit: 25 - 200 mg/kg LD50 dermal Rat 370 mg/kg
Limited Quantities 100ml (liquid) or 0.5 Kg (solid)
Excepted Quantities Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml)
NFPA 704
2
1 0

2-Acetylthiophene price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A22602 2-Acetylthiophene 98% 88-15-3 25g $38 2023-06-20 Buy
Sigma-Aldrich W503509 2-Acetylthiophene ≥98%, FG 88-15-3 250g $173 2023-06-20 Buy
Sigma-Aldrich W503509 2-Acetylthiophene ≥98%, FG 88-15-3 1kg $521 2023-01-07 Buy
Sigma-Aldrich 8.00175 2-Acetylthiophene for synthesis 88-15-3 50mL $110 2023-01-07 Buy
Sigma-Aldrich 8.00175 2-Acetylthiophene for synthesis 88-15-3 250ML $450 2023-01-07 Buy
Product number Packaging Price Buy
A22602 25g $38 Buy
W503509 250g $173 Buy
W503509 1kg $521 Buy
8.00175 50mL $110 Buy
8.00175 250ML $450 Buy

2-Acetylthiophene Chemical Properties,Uses,Production

Description

2-Acetylthiophene occurs naturally in kohlrabi. It has a sulfurous nutty hazelnut odor. It can be used as a food additive. It is also used as an intermediate to produce drugs, such as Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc.

Chemical Properties

clear colorless to slightly yellow liquid

Uses

2-Acetylthiophene(2AT) is used as an intermediate in the manufacturing of drugs like Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc. 2AT is used as an important precursor to thiophene-2-acetic acid (T2AA) or its acid chloride (Cl) and thiophene-2-carboxylic acid (T2CA) (Cl). It is important that the process used to synthesize 2AT yields the lowest amount of 3- acetylthiophene isomer.

Definition

ChEBI: 2-Acetylthiophene is an aromatic ketone.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 8, 1943
The Journal of Organic Chemistry, 36, p. 540, 1971 DOI: 10.1021/jo00803a011
Tetrahedron Letters, 40, p. 3109, 1999 DOI: 10.1016/S0040-4039(99)00476-1

Safety Profile

Poison by intraperitoneal route. A flammable liquid. When heated to decomposition emits toxic fumes of SOx,.

Solubility in organics

2-Acetylthiophene is miscible at 25°C with triethylene glycol, methanol, ethanol, n-butanol, diethyl ether, dioxane, cellulose butyl ester, ethyl acetate, acetone, acetonitrile, carbon disulphide, carbon tetrachloride, nitromethane, acetic acid, thiophene, tetranaphthalene, aminobenzene, and benzene . It is immiscible with water, glycerol, ethylene glycol, decahydronaphthalene, cyclohexane, diisobutylene, 1-hexadecene, and n-heptane. When equal volumes are mixed, 2-acetylthiophene is miscible with n-heptane above 60.8°C and with ethylene glycol above 31.1°C.
[1] JOHNSON G C. Physical Properties of 2-Acetylthiophene[J]. Journal of the American Chemical Society, 1947, 69 1: 150-152. DOI:10.1021/ja01193a040.

Purification Methods

Fractionally distil the thiophene through a 12-plate column, and fraction b 77o/4mm is collected. Also wet the acetylthiophene in order to remove and free thiophene which forms an azeotrope with H2O, b 68o. Store it in a brown bottle, and the clear colourless liquid remains thus for extended periods. [Kosak & Hartough Org Synth Coll Vol III 14 1955, Hartough & Kosak J Am Chem Soc 69 3093 1947.] The red 4-nitrophenylhydrazone crystallises from EtOH with m 181-182o. [Beilstein 17/9 V 387.]

2-Acetylthiophene Preparation Products And Raw materials

Raw materials

Acetyl chloride

Preparation Products

5-[2-(METHYLTHIO)PYRIMIDIN-4-YL]THIOPHENE-2-SULFONYL CHLORIDE 1-(4-BROMO-2-THIENYL)ETHAN-1-ONE 5-THIEN-2-YL-4H-PYRAZOLE-3-CARBOXYLIC ACID Ethyl 5-thien-2-yl-1H-pyrazole-3-carboxylate N-(2-THIOPHENECARBOMYL)PYRIDINIUM BROMIDE
3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER 4-Bromo-2-thiophenecarboxylic acid 5-ACETYL-2-THIOPHENECARBALDEHYDE 2-Thiopheneacetic acid 2-(2-BROMOACETYL)THIOPHENE
2-Acetyl-5-bromothiophene 2-(2-thienyl)propionic acid 1-[2-Hydroxy-2(2-thienyl)ethyl]pyridinium bromide 2,4-DIOXO-4-THIOPHEN-2-YL-BUTYRIC ACID METHYL ESTER 5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide
THIOPHENE-2-ACETAMIDE 1,3,5-tri(thiophen-2-yl)benzene 2-ACETYL-4-CHLOROTHIOPHENE 2,5-Dihydrothiophene 2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL

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2-Acetylthiophene Suppliers

Global( 702)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Yingrui Biopharma Co.,Ltd
21-33585366 export01@shyrchem.com CHINA 1319 58
Suzhou Yangen Biotech Co.Ltd
+8615051547453 christina@yangenbiotech.com China 230 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8753 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5242 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20128 58
airuikechemical co., ltd. 		+86-18353166132 sales02@airuikechemical.com China 983 58
JINING XINHE CHEMICAL CO., LTD 		+8615318402391 sales@xinhepharma.com China 809 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13620 58
Supplier Advantage
Shanghai Yingrui Biopharma Co.,Ltd
58
Suzhou Yangen Biotech Co.Ltd
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
airuikechemical co., ltd. 		58
JINING XINHE CHEMICAL CO., LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58

Related Qustion

Ask a question
Q:What is 2-Acetylthiophene used for?STAR - Nov 25，2025
A:2-Acetylthiophene is a multi-functional small-molecule compound that can react with various chemical reagents to synthesise other heterocyclic compounds, while also serving as a common subject for structural analysis research. It is widely employed in thermochemical, physical, molecular mechanics, and spectroscopic experimental studies. Under Vilsmeier reaction conditions, 2-acetylthiophene can be used to synthesise β-chloro-β-(2-thienyl)acrolein or N,N-dimethyl-2-thienylformamide. It may also react with phosphorus pentachloride to yield 2-(2-thienyl)-2-chloroethyl phosphonic acid.

View Lastest Price from 2-Acetylthiophene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Acetylthiophene pictures 2026-01-28 2-Acetylthiophene
88-15-3
 0.99 RongNa Biotechnology Co.,Ltd
2-ACETYLTHIOPHENE pictures 2026-01-05 2-ACETYLTHIOPHENE
88-15-3
 US $1.00 / PCS 1PCS 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Acetylthiophene pictures 2025-11-20 2-Acetylthiophene
88-15-3
 US $0.00-0.00 / kg 1kg 98% 100tons Shandong Vital Biotechnology Co., Ltd.

2-Acetylthiophene Spectrum

2-Acetylthiophene(88-15-3)MS2-Acetylthiophene(88-15-3)1HNMR2-Acetylthiophene(88-15-3)13CNMR2-Acetylthiophene(88-15-3)IR12-Acetylthiophene(88-15-3)Raman

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1-(2-THIENYL)ETHAN-1-ONE AKOS BBS-00000940 AKOS 91936 2-ACETYLTHIOLE 2-ACETYLTHIOPHENE 2-ACETOTHIOPHENE LABOTEST-BB LT01593557 METHYL 2-THIENYL KETONE 2-ACETYLTHIOPHENE 98+% 2-Acetylthiophene99% acetylthiophene,2-acetylthiophene Ethanone, 1-(2-thienyl)- 2-ACETYLBROMOTHIOPHENE 1-(2-Thienyl)-1-ethanone 1-(Thien-2-yl)ethan-1-one 2-Acetylthiophene, 98% 100GR METHYL 2-THIENYL KETONE FOR SYNTHESIS 1-(2-thienyl)-ethanon 1-thiophen-2-yl-ethanone 2-acethylthiophene 2-Acetothienone 2-Acetylthiophen 2-Thienyl methyl ketone 2-thienylmethylketone alpha-acetylthiophene Ketone, methyl 2-thienyl ketone,methyl2-thienyl thiophene,2-acetyl- 2 - thiophene ethyl ketone 2-Acetylthioph 2-Acetylthiophene in stock Factory 2-Acetylthiophene > High Quality 2-Acetylthiophene 2-Acetylthiophene USP/EP/BP 2-Acetylthiophene (Stellar-2002) 2-Acetyl Thiophene pure, 99% Avatrombopag Impurity 95 -Acetylthiophene 5-BROMO-4-(THIOPHEN-2-YL)-1,3-THIAZOL-2-AMINE Acetonitrile Dried Special 2-Acetylthiophene 98% For Synthesis Aficamten Impurity 11 Methyl-2-thienylketon 5-bromo-4-(4-bromothiophen-2-yl)thiazol-2-amine 2-Acetylthiophene, 95% 2-Acylthiophene 88-15-3 8-15-3 CH3COC4H3S Thiophenes Heterocyclic Building Blocks KETONE Building Blocks Heterocycle-oher series Sulphur Derivatives Thiophene&Benzothiophene thiophene Flavor Thiophenes