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PX-866-17OH

PX-866-17OH Structure
PX-866-17OH structure
CAS No.
1012327-63-7
Chemical Name:
PX-866-17OH
Synonyms
PX-866-17OH;(1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione;Cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione, 5-(acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-, (1E,4S,4aR,5R,6aS,7S,9aR)-
CBNumber:
CB44666794
Molecular Formula:
C29H37NO8
Molecular Weight:
527.61
MDL Number:
MOL File:
1012327-63-7.mol
MSDS File:
SDS
Last updated:2026-05-11 16:31:51
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PX-866-17OH Properties

Boiling point 651.2±55.0 °C(Predicted)
Density 1.28±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: soluble
form A crystalline solid
pka 8.36±0.70(Predicted)

PX-866-17OH price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21204 PX-866-17OH ≥98% 1012327-63-7 1mg $141 2026-04-30 Buy
Cayman Chemical 21204 PX-866-17OH ≥98% 1012327-63-7 5mg $352 2026-04-30 Buy
Cayman Chemical 21204 PX-866-17OH ≥98% 1012327-63-7 10mg $561 2026-04-30 Buy
Biosynth MQB32763 PX-866-17OH 1012327-63-7 10mg $1031.1 2026-06-04 Buy
Biosynth MQB32763 PX-866-17OH 1012327-63-7 25mg $1681.25 2026-06-04 Buy
Product number Packaging Price Buy
21204 1mg $141 Buy
21204 5mg $352 Buy
21204 10mg $561 Buy
MQB32763 10mg $1031.1 Buy
MQB32763 25mg $1681.25 Buy

PX-866-17OH Chemical Properties, Uses, Production

Description

PX-866-17OH is an active metabolite of PX-866 . It inhibits PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ (IC50s = 14, 57, 131, and 148 nM, respectively).

Uses

PX-866-17OH is the metabolite of PX-866 (Sonolisib, HY-N6775) and a pan-isoform inhibitor of PI3K with IC50s of 14, 57, 131, and 148 nM against PI3Kα, PI3Kβ, PI3K , and PI3Kδ, respectively[1].

References

[1] Zask A, et al. Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51(5):1319-23. DOI:10.1021/jm7012858

PX-866-17OH Preparation Products And Raw materials

Raw materials

Preparation Products

PX-866-17OH Suppliers

Global Suppliers ( 12)
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from PX-866-17OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PX-866-17OH pictures 2026-05-11 PX-866-17OH
1012327-63-7
 $463.00-1830.00 10g TargetMol Chemicals Inc.
  • PX-866-17OH pictures
  • PX-866-17OH
    1012327-63-7
  • $463.00-1830.00
  • TargetMol Chemicals Inc.

1012327-63-7 (PX-866-17OH) Related Search:

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gamma-Glu-Cys trifluoroacetate salt

1of2

PX-866-17OH Cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione, 5-(acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-, (1E,4S,4aR,5R,6aS,7S,9aR)- (1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione 1012327-63-7