PX-866-17OH manufacturers
- PX-866-17OH
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- $1130.00
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2026-05-11
- CAS:1012327-63-7
- Purity:
- Supply Ability: 10g
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| | PX-866-17OH Basic information |
| Product Name: | PX-866-17OH | | Synonyms: | PX-866-17OH;Cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione, 5-(acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-, (1E,4S,4aR,5R,6aS,7S,9aR)-;(1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione | | CAS: | 1012327-63-7 | | MF: | C29H37NO8 | | MW: | 527.61 | | EINECS: | | | Product Categories: | | | Mol File: | 1012327-63-7.mol |  |
| | PX-866-17OH Chemical Properties |
| Boiling point | 651.2±55.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A crystalline solid | | pka | 8.36±0.70(Predicted) |
| | PX-866-17OH Usage And Synthesis |
| Description | PX-866-17OH is an active metabolite of PX-866 . It inhibits PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ (IC50s = 14, 57, 131, and 148 nM, respectively). | | Uses | PX-866-17OH is the metabolite of PX-866 (Sonolisib, HY-N6775) and a pan-isoform inhibitor of PI3K with IC50s of 14, 57, 131, and 148 nM against PI3Kα, PI3Kβ, PI3K , and PI3Kδ, respectively[1]. | | References | [1] Zask A, et al. Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51(5):1319-23. DOI:10.1021/jm7012858 |
| | PX-866-17OH Preparation Products And Raw materials |
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