GNE-6468
- CAS No.
- 1677668-27-7
- Chemical Name:
- GNE-6468
- Synonyms
- GNE-6468;GNE 6468,GNE6468;Benzoic acid, 4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxy-
- CBNumber:
- CB44667953
- Molecular Formula:
- C23H16ClN3O4
- Molecular Weight:
- 433.84
- MDL Number:
- MOL File:
- 1677668-27-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
GNE-6468 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | CSC66827 | GNE-6468 | 1677668-27-7 | 1mg | $250 | 2026-06-04 | Buy |
| Biosynth | CSC66827 | GNE-6468 | 1677668-27-7 | 5mg | $389.8 | 2026-06-04 | Buy |
| Biosynth | CSC66827 | GNE-6468 | 1677668-27-7 | 10mg | $623.7 | 2026-06-04 | Buy |
| Biosynth | CSC66827 | GNE-6468 | 1677668-27-7 | 25mg | $1169.5 | 2026-06-04 | Buy |
| Biosynth | CSC66827 | GNE-6468 | 1677668-27-7 | 50mg | $1871 | 2026-06-04 | Buy |
GNE-6468 Chemical Properties, Uses, Production
Description
GNE-6468 is a potent and selective RORc inverse agonist. GNE-6468 displayed >300-fold selectivity for RORc over the other ROR family members, PPARγ, and NRs in our cellular selectivity panel. The favorable potency, selectivity, and physiochemical properties of GNE-6468, in addition to its potent suppression of IL-17 production in human primary cells, support its use as chemical biology tools to further explore the role of RORc in human biology. The nuclear receptor (NR) retinoic acid receptor-related orphan receptor gamma (RORγ, RORc, or NR1F3) is a promising target for the treatment of autoimmune diseases. RORc is a critical regulator in the production of the pro-inflammatory cytokine interleukin-17.
Uses
GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC[1].
in vivo
GNE-6468 (compound 28) displays high predicted clearance values in human and rodent hepatocytes (CLhep = 17 and 42 mL/min/kg, respectively) [1].
IC 50
ROR-γ: 2 nM (EC50)
References
[1] Fauber BP, et al. Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12. DOI:10.1016/j.bmcl.2015.05.055
GNE-6468 Preparation Products And Raw materials
Raw materials
Preparation Products
GNE-6468 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2970 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
