PROSTAGLANDIN J2
- CAS No.
- 60203-57-8
- Chemical Name:
- PROSTAGLANDIN J2
- Synonyms
- PGJ2;Aids058772;Aids-058772;PROSTAGLANDIN J2;PGJ2 (Prostaglandin J2);Prostaglandin J2 (PGJ2);Prostaglandin J2 (Standard);Prostaglandin J2, PGD2 analog;9-deoxy-delta-9-prostaglandind2;Prostaglandin J2 Lipid Maps MS Standard
- CBNumber:
- CB4477024
- Molecular Formula:
- C20H30O4
- Molecular Weight:
- 334.45
- MDL Number:
- MFCD00065804
- MOL File:
- 60203-57-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 521.7±50.0 °C(Predicted) |
|---|---|
| Density | 1.103±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMF: >100 mg/ml (from PGD2); DMSO: >50 mg/ml (from PGD2); Ethanol: >75 mg/ml (from PGD2); PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-.DEL |
| pka | 4.75±0.10(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
| EWG's Food Scores | 1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
| Hazard Codes | Xn,Xi,F | |||||||||
| Risk Statements | 20/21/22-36/37/38-67-66-36-11 | |||||||||
| Safety Statements | 26-36-33-29-16 | |||||||||
| NFPA 704 |
|
PROSTAGLANDIN J2 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18500 | Prostaglandin J2 ≥95% | 60203-57-8 | 500μg | $97 | 2026-04-30 | Buy |
| Cayman Chemical | 18500 | Prostaglandin J2 ≥95% | 60203-57-8 | 1mg | $184 | 2026-04-30 | Buy |
| Cayman Chemical | 18500 | Prostaglandin J2 ≥95% | 60203-57-8 | 5mg | $775 | 2026-04-30 | Buy |
| Cayman Chemical | 18500 | Prostaglandin J2 ≥95% | 60203-57-8 | 10mg | $1356 | 2026-04-30 | Buy |
| Usbiological | 462340 | PGJ2 (Prostaglandin J2) | 60203-57-8 | 1mg | $489 | 2026-06-03 | Buy |
PROSTAGLANDIN J2 Chemical Properties, Uses, Production
Description
Prostaglandin J2 (PGJ2) is formed from PGD2 by the elimination of the C-
Uses
PGJ2 (Prostaglandin J2) is a Prostaglandin D2 metabolite that has shown potent anti-neoplastic and antiviral activity.
Definition
ChEBI: A member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer).
in vivo
Prostaglandin J2 (PGJ2; 33.4 μg/injection; unilateral injection to the SNpc; once per week for 2 or 4 weeks) induces progressive PD-like pathology and exhibites microglia and astrocyte activation and motor deficits in the rats[4].
| Animal Model: | Sixteen-week-old Sprague Dawley male rats[4] |
| Dosage: | 33.4 μg/injection |
| Administration: | Unilateral (right side) injections to the SNpc; once per week for 2 or 4 weeks |
| Result: | Induced progressive dopaminergic neuronal loss in the rat substantia nigra pars compacta (SNpc). Developed parkinsonian-like motor deficits in a progressive manner. |
IC 50
hDP: 0.9 nM (Ki); hCRTH2: 6.6 nM (Ki); hEP1: 15.678 μM (Ki); hEP2: 989 nM (Ki); hEP3: 319 nM (Ki); hEP4: 1065 nM (Ki); hFP: 553 nM (Ki); hIP: >25 μM (Ki); hTP: 6426 nM (Ki); Human Endogenous Metabolite
References
[1] D. HAMISH WRIGHT. Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist[J]. British Journal of Pharmacology, 2009, 123 7: 1317-1324. DOI: 10.1038/sj.bjp.0701708
[2] NICOLE SAWYER. Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2[J]. British Journal of Pharmacology, 2009, 137 8: 1163-1172. DOI: 10.1038/sj.bjp.0704973
[3] TENEKA JEAN-LOUIS Maria E F P Patricia Rockwell. Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α- and β-secretases: relevance to Alzheimer’s disease[J]. Neurobiology of Aging, 2018, 62: Pages 130-145. DOI: 10.1016/j.neurobiolaging.2017.10.009
[4] MARIA E. FIGUEIREDO-PEREIRA John B Chuhyon Corwin. Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration[J]. Annals of the New York Academy of Sciences, 2016, 1363 1: 125-137. DOI: 10.1111/nyas.12987
[5] CHUHYON CORWIN. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets.[J]. Journal of Neuroinflammation, 2018: 272. DOI: 10.1186/s12974-018-1305-3
[6] ABHITA MALAVIYA Paul W S. Synergistic Antiproliferative Effects of Combined γ -Tocotrienol and PPAR γ Antagonist Treatment Are Mediated through PPAR γ -Independent Mechanisms in Breast Cancer Cells.[J]. PPAR Research, 2014: 439146. DOI: 10.1155/2014/439146
PROSTAGLANDIN J2 Preparation Products And Raw materials
Raw materials
Preparation Products
PROSTAGLANDIN J2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| amyjet | 4006800868;027-59626688 18771149750 | sales@amyjet.com | China | 2909 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Hubei Aiputi Bioengineering Co., Ltd. | 17762444226 | d17762444226@163.com | China | 2400 | 58 |
60203-57-8 (PROSTAGLANDIN J2) Related Search:
1of4
