2-Methyl-1,3-benzothiazol-6-ol
- CAS No.
- 68867-18-5
- Chemical Name:
- 2-Methyl-1,3-benzothiazol-6-ol
- Synonyms
- 2-methylbenzo[d]thiazol-6-ol;2-METHYL-6-BENZOTHIAZOLOL;6-Benzothiazolol, 2-methyl-;2-Methylbenzothiazol-6-ol,96%;2-Methyl-1,3-benzothiazol-6-ol;2-Methylbenzothiazol-6-ol, 96%;6-HYDROXY-2-METHYLBENZOTHIAZOLE;6-Hydroxy-2-methylbenzothiazole 97%;6-Benzothiazolol,2-methyl-(6CI,7CI,9CI)
- CBNumber:
- CB4479619
- Molecular Formula:
- C8H7NOS
- Molecular Weight:
- 165.21
- MDL Number:
- MFCD00227234
- MOL File:
- 68867-18-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P280a-P301+P310a-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2934208090 | |||||||||
| NFPA 704 |
|
2-Methyl-1,3-benzothiazol-6-ol price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR936497 | 2-Methyl-1,3-benzothiazol-6-ol 97% | 68867-18-5 | 250mg | $25 | 2026-06-04 | Buy |
| Apolloscientific | OR936497 | 2-Methyl-1,3-benzothiazol-6-ol 97% | 68867-18-5 | 1g | $30 | 2026-06-04 | Buy |
| Apolloscientific | OR936497 | 2-Methyl-1,3-benzothiazol-6-ol 97% | 68867-18-5 | 5g | $122 | 2026-06-04 | Buy |
| Apolloscientific | OR936497 | 2-Methyl-1,3-benzothiazol-6-ol 97% | 68867-18-5 | 25g | $421 | 2026-06-04 | Buy |
| Matrix Scientific | 135633 | 2-Methylbenzo[d]thiazol-6-ol | 68867-18-5 | 1.00g | $101 | 2026-05-18 | Buy |
2-Methyl-1,3-benzothiazol-6-ol Chemical Properties, Uses, Production
Uses
2-Methyl-1,3-benzothiazol-6-ol is a useful reactant for the preparation of G protein-biased D2 dopamine receptor partial agonists.
Synthesis
2941-72-2
68867-18-5
The general procedure for the synthesis of 2-methyl-6-hydroxybenzothiazole from 6-methoxy-2-methylbenzothiazole is as follows: to a dichloromethane solution (10 ml) of 6-methoxy-2-methylbenzothiazole (500 mg, 2.79 mmol) was slowly added to a dichloromethane solution (8.4 ml, 8.40 mmol) of boron bromide (8.4 ml) at -78°C and under nitrogen protection . The reaction mixture was then warmed to 0°C and stirred continuously at this temperature for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of water to the reaction mixture, followed by extraction with dichloromethane. The combined organic phases were washed sequentially with saturated aqueous sodium bicarbonate and pure water, followed by drying with anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure and the resulting crude product was purified by medium pressure preparative liquid chromatography (Yamazen Corporation, W-Prep 2XY) to give 2-methyl-6-hydroxybenzothiazole (103 mg, 22% yield) as a colorless oil. The structure of the product was confirmed by 1H-NMR (CDCl3, 400 MHz) and mass spectrometry (ESI): 1H-NMR δ 7.66 (1H, d, J = 8.8 Hz), 7.23 (1H, d, J = 2.4 Hz), 6.94 (1H, dd, J = 8.8 Hz, 2.4 Hz), 2.74 (3H, s); MS (ESI, m/z). 166 (M + H)+.
References
[1] Helvetica Chimica Acta, 1992, vol. 75, # 4, p. 1185 - 1197
[2] Patent: EP2258697, 2010, A1. Location in patent: Page/Page column 117
[3] Zhurnal Obshchei Khimii, 1949, vol. 19, p. 1158,1159, 1164; engl. Ausg. S. 1153, 1154,1159
[4] Sb. Statei Obshch. Khim., 1953, p. 1263,1264, 1266, 1271
[5] Chem.Abstr., 1955, p. 5443
2-Methyl-1,3-benzothiazol-6-ol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. | 21-54820552 17702105771 | 188738128@qq.com | China | 300 | 66 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Jinan HM Medical Technology Co., Ltd. | 0531-88262980 13156180564 | jnhengmao@163.com | China | 100 | 62 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Suzhou Sibian Chemical Technology Co.,Ltd. | 0512-65617459 18915409046 | sales@sibian-chem.com | China | 1917 | 55 |
View Latest Price from 2-Methyl-1,3-benzothiazol-6-ol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 2-METHYL-1,3-BENZOTHIAZOL-6-OL
68867-18-5
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2-METHYL-1,3-BENZOTHIAZOL-6-OL
68867-18-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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