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D-Luciferin

D-Luciferin structure

CAS No.: 2591-17-5

Chemical Name:: D-Luciferin

Synonyms: LUCIFERIN;BEETLE LUCIFERIN;FIREFLY LUCIFERIN;Photinus luciferin;uciferin;D-LUCIFERIN;D-Leciferin;?-Luciferin;LUCIFERIN, D-;D-fluorescein

CBNumber:: CB8283216

Molecular Formula:: C11H8N2O3S2

Molecular Weight:: 280.32

MDL Number:: MFCD00042929

MOL File:: 2591-17-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-08-20 20:20:01

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D-Luciferin Properties

Melting point	200-204 °C
alpha	D22 -36° (c = 1.2 in DMF)
Boiling point	587.6±60.0 °C(Predicted)
Density	1.4916 (rough estimate)
refractive index	1.5650 (estimate)
storage temp.	-20°C
solubility	DMF:30.0(Max Conc. mg/mL);107.02(Max Conc. mM) DMSO:35.33(Max Conc. mg/mL);126.05(Max Conc. mM)
pka	8.31±0.40(Predicted)
form	Powder
color	Off-white to light yellow
biological source	synthetic
λmax	360nm(H2O)(lit.)
Merck	14,4086
BRN	30484
InChI	InChI=1S/C11H8N2O3S2/c14-5-1-2-6-8(3-5)18-10(12-6)9-13-7(4-17-9)11(15)16/h1-3,7,14H,4H2,(H,15,16)/t7-/m1/s1
InChIKey	BJGNCJDXODQBOB-SSDOTTSWSA-N
SMILES	S1C[C@H](C(O)=O)N=C1C1=NC2=CC=C(O)C=C2S1
FDA UNII	5TBB02N29K
UNSPSC Code	12352204
NACRES	NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P271-P280
PPE	Eyeshields, Gloves, type N95 (US)
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37/39-24/25
WGK Germany	3
F	8-10
HS Code	29342000
Storage Class	11 - Combustible Solids

D-Luciferin price More Price(93)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	L6152	D-Luciferin synthetic, BioXtra, ≥99% (HPLC)	2591-17-5	1mg	$309	2026-04-30	Buy
Sigma-Aldrich	L6152	D-Luciferin synthetic, BioXtra, ≥99% (HPLC)	2591-17-5	10mg	$1520	2026-04-30	Buy
TCI Chemical	A5030	D-(-)-Luciferin [Chemiluminescence Reagent] >98.0%(HPLC)	2591-17-5	10mg	$194	2026-04-30	Buy
TCI Chemical	A5030	D-(-)-Luciferin [Chemiluminescence Reagent] >98.0%(HPLC)	2591-17-5	50mg	$591	2026-04-30	Buy
Cayman Chemical	25836	D-Luciferin ≥95%	2591-17-5	10mg	$41	2026-04-30	Buy

Product number	Packaging	Price	Buy
L6152	1mg	$309	Buy
L6152	10mg	$1520	Buy
A5030	10mg	$194	Buy
A5030	50mg	$591	Buy
25836	10mg	$41	Buy

D-Luciferin Chemical Properties, Uses, Production

Description

D-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP, used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications. In an immunocompetent mouse model of ovarian cancer, the use of D-luciferin substrate and firefly luciferase preserves tumour-host immune interactions since bioluminescent imaging is a more sensitive indication of tumour growth than weight gain.

Chemical Properties

off-white to light yellow powder

Uses

In the assay of ATP.

Uses

D-Luciferin has been used in the preparation of the reaction mixture for nitric oxide determination by minescence measurement. It has also been used in the preparation of D-luciferin stock solution for luciferin assays.

Uses

D-Luciferin has been used in determining luciferase activity by luciferase assay in mice and Arabidopsis thaliana seeds. It has also been used in measuring bioluminescence in neonatal rat ventricular cardiomyocytes.

Definition

ChEBI: A 1,3-thiazolemonocarboxylic acid consisting of 3,5-dihydrothiophene-4-carboxylic acid having a 6-hydroxybenzothiazol-2-yl group at the 2-position.

General Description

D-Luciferin is a small molecule present abundantly in bioluminescent organisms. This molecule is sensitive to oxygen and light.

Biochem/physiol Actions

D-Luciferin uptake within the cells is regulated by the adenosine triphosphate (ATP)-binding cassette (ABC) transporter inhibitors like ATP-binding cassette transporter G2 (ABCG2)/ breast cancer resistance protein (BCRP) inhibitor fumitremorgin C. This substrate is oxidized by firefly luciferase that results in emitting a photon, which has the capability of passing through living tissues.

Purification Methods

D-Luciferin crystallises as pale yellow needles from H2O, or MeOH (83mg/7mL). It has UV max at 263 and 327nm (log 3.88 and 4.27) in 95% EtOH. The Na salt has a solubility of 4mg in 1 mL of 0.05M glycine. [White et al. J Am Chem Soc 83 2402 1961, 85 337 1963, UV and IR: Bitler & McElroy Arch Biochem 72 358 1957, Review: Cormier et al. Fortschr Chem Org Naturst 30 1 1973, Beilstein 27 III/IV 8934.]

D-Luciferin Preparation Products And Raw materials

Raw materials

Preparation Products

D-Luciferin Suppliers

Global Suppliers ( 443)

Supplier	Tel	Email	Country	ProdList	Advantage
Heliosense Biotechnologies,Inc	0592-5667290 18649641090	info@heliosense.com	China	98	58
Dezhou LonWel Pharmaceutical Technology Co., Ltd.	13761310616	39324283@qq.com	China	1359	58
Shanghai Chino Pharmaceutical Technology Co., Ltd	021-021-51557188 15901710861	sales@channelpharm.com	China	1253	58
Xi’an Yino Biotechnology Co., Ltd.	18809207782 18809207782	527644240@qq.com	China	543	58
Hubei Innerse Biotechnology Co., Ltd.	88189299 18186187538	2479490947@qq.com	China	104	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Heliosense Biotechnologies,Inc	58
Dezhou LonWel Pharmaceutical Technology Co., Ltd.	58
Shanghai Chino Pharmaceutical Technology Co., Ltd	58
Xi’an Yino Biotechnology Co., Ltd.	58
Hubei Innerse Biotechnology Co., Ltd.	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
TCI (Shanghai) Development Co., Ltd.	81

View Latest Price from D-Luciferin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-17	D-luciferin 2591-17-5		10G	98%min	30kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-08-19	D-Luciferin 2591-17-5	$45.00-119.00		99.37%	10g	TargetMol Chemicals Inc.
2025-04-04	D-Luciferin 2591-17-5		1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

D-luciferin
2591-17-5
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

D-Luciferin
2591-17-5
$45.00-119.00
99.37%
TargetMol Chemicals Inc.

D-Luciferin
2591-17-5
98%
Henan Aochuang Chemical Co.,Ltd.

D-Luciferin Spectrum

D-LUCIFERIN(2591-17-5)¹HNMR

2591-17-5 (D-Luciferin) Related Search:

D-Luciferin potassium salt L-LUCIFERIN,L-Luciferin free acid, 99%,L-Luciferin free acid, 99%,L-LUCIFERIN Coelenterazine D-Luciferin D-Luciferin sodium salt

LUCIFERASE 6-Benzothiazolol(7CI,8CI,9CI) D-LUCIFERIN D-Luciferin, ethyl ester D-luciferin 6-O-phosphate sodium,D-LUCIFERIN 6'-O-PHOSPHATE TRISODIUM &,D-LUCIFERIN 6'-O-PHOSPHATE TRISODIUM &,D-luciferin 6-O-phosphate sodium

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4,5-Dihydro-2[6-amino-2-benzthiazolyl]-4-thiazole carboxylic acid 4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid potassium salt 4,5-Dihydro-2-[6-methoxy-2-benzothiazolyl]-4-thiazolinecarboxylic acid sodium salt

1of4

4,5-DIHYDRO-2-(6-HYDROXY-2-BENZOTHIAZOLYL)-4-THIAZOLECARBOXY 4,5-DIHYDRO-2-[6-HYDROXY-2-BENZOTHIAZOLYL]-4-THIAZOLE-CARBOXYLIC ACID 4,5-DIHYDRO-(6-HYDROXY-2-BENZOTHIAZOYL)-4-THIAZOLE CARBOXYLIC ACID LUCIFERIN, D- D(-)-2-(6'-HYDROXY-BENZOTHIAZOLYL)-DELTA2-THIAZOLINE-4-CARBOXYLIC ACID D(-)-LUCIFERIN D-LUCIFERIN D-LUCIFERIN FIREFLY D-Luciferin≥ 99% (HPLC) D-Luciferin, free acid *CAS#: 2591-17-5* (S)-4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4 thiazolecarboxylic acid (4S)-2-(6-Hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid Luciferin, D- - Firefly Luciferin 2-(6-oxo-1,3-benzothiazol-2-ylidene)-4-thiazolidinecarboxylic acid AURORA KA-6717 (S)-2-[6-HYDROXY-2-BENZOTHIAZOLYL]-2-THIAZOLENE-4 (S)-2-(6-HYDROXY-2-BENZOTHIAZOLYL)-2-THIAZOLINE-4-CARBOXYLIC ACID (S)-4,5-dihydro-2-(6-hydroxybenzothiazol-2-yl)thiazole-4-carboxylic acid D-Luciferin free acid, 99% D-LUCIFERIN SYNTHETIC D-LUCIFERIN SIGMAULTRA D -LUCIFERIN SYNTHETIC CRYSTALLINE Beetle luciferin Firefly luciferin D-LUCIFERIN,FREEACID,ULTRAPURE D-Leciferin (4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid D-(-)-Luciferin (D)-4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid, Firefly (synthetic), 99% D-LUCIFERINFREEACID,99% D-Luciferin, Free acid >99.5% 2-(6-Hydroxy-benzothiazol-2-yl)-thiazole-4-carboxylic acid D-Luciferin Firefly Luciferin, (S)-2-(6-Hydroxy-2-benzothiazolyl)-2-thiazoline-4-carboxylic acid, 4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid (4S)-2-(6-Hydroxy-2-benzothiazolyl)-2-thiazoline-4β-carboxylic acid (4S)-2-(6-Hydroxybenzothiazole-2-yl)-2-thiazoline-4-carboxylic acid D-(-)-Luciferin [Chemiluminescence Reagent] (4S)-4,5-Dihydro-(6-hydroxy-2-benzothiazoyl)-4-thiazolecarboxylic acid (S)-2-(6-hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid D-(-)-Luciferin [Chemiluminescence Reagent]> uciferin 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, (4S)- D-luciferin (Firefly luciferin) D-Luciferin ex. Firefly, 99% 7-Dihydroxyflavone D-Luciferin Firefly, Free Acid D-Luciferin, chemiluminescent luciferase substrate D-Luciferin, free acid UltraPure Grade - 25 mg D-Luciferin ?-Luciferin D-Luciferin[L9504] D-Luciferinfreeacid (S)-4,5-dihydro-2-(6-hydroxybenzenebenzothiazole-2-yl)thiazole-4-macetic acid FIREFLY LUCIFERIN BEETLE LUCIFERIN LUCIFERIN Photinus luciferin D-fluorescein 2591-17-5 2951-17-5