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Soravtansine

Soravtansine structure

CAS No.: 1461704-01-7

Chemical Name:: Soravtansine

Synonyms: Soravtansine;Sulfo-PDBA-DM4;Sulfo-PDBA-DM4, 98%，;Maytansine, N2'-[4-[(3-carboxy-3-sulfopropyl)dithio]-4-methyl-1-oxopentyl]-N2'-deacetyl-;Maytansine, N2′-[4-[(3-carboxy-3-sulfopropyl)dithio]-4-methyl-1-oxopentyl]-N2′-deacetyl- (ACI);4-[(4-{[(2S)-1-{[(1S,2R,3S,5S,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.11?,1?.03,?]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy}-1-oxopropan-2-yl](methyl)carbamoyl}-2-methylbutan-2-yl)disulfanyl]-2-sulfobutanoic acid

CBNumber:: CB44848220

Molecular Formula:: C42H60ClN3O15S3

Molecular Weight:: 978.58

MDL Number:: MFCD32263224

MOL File:: 1461704-01-7.mol

Last updated:2025-04-18 09:52:19

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Soravtansine Properties

Density	1.41±0.1 g/cm3(Predicted)
pka	0.09±0.50(Predicted)
FDA UNII	6PON74J1XY

Soravtansine Chemical Properties, Uses, Production

Uses

Sulfo-PDBA-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Sulfo-PDBA to make antibody agent conjugate (ADC). Sulfo-PDBA is a gluthatione cleavable linker.

IC 50

Maytansinoids

References

[1] Sun X, et al. Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates. Bioconjug Chem. 2017 May 17;28(5):1371-1381. DOI:10.1021/acs.bioconjchem.7b00062

Soravtansine Preparation Products And Raw materials

Raw materials

Preparation Products

Soravtansine Suppliers

Global Suppliers ( 7)

Supplier	Tel	Email	Country	ProdList	Advantage
Twochem Co.Ltd	021-021-58111628 15800915896	sales@twochem.com	China	303	55
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9718	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Zhengzhou Converging Chemical Co. LTD	0371-53399770 18037166334	3857571523@qq.com	China	7173	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
Qingdao Haizhi Weiyuan Biotechnology Co., Ltd.	18317699790 18317699790	l202008112023@163.com	China	7733	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60

Supplier	Advantage
Twochem Co.Ltd	55
Fan De(Beijing) Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Zhengzhou Converging Chemical Co. LTD	58
TargetMol Chemicals Inc.	58
Qingdao Haizhi Weiyuan Biotechnology Co., Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60

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Soravtansine Sulfo-PDBA-DM4 Maytansine, N2'-[4-[(3-carboxy-3-sulfopropyl)dithio]-4-methyl-1-oxopentyl]-N2'-deacetyl- Sulfo-PDBA-DM4, 98%， 4-[(4-{[(2S)-1-{[(1S,2R,3S,5S,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.11?,1?.03,?]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy}-1-oxopropan-2-yl](methyl)carbamoyl}-2-methylbutan-2-yl)disulfanyl]-2-sulfobutanoic acid Maytansine, N2′-[4-[(3-carboxy-3-sulfopropyl)dithio]-4-methyl-1-oxopentyl]-N2′-deacetyl- (ACI) 1461704-01-7 C42H60ClN3O15S3