| Company Name: |
Twochem Co.Ltd |
| Tel: |
021-021-58111628 15800915896 |
| Email: |
sales@twochem.com |
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| | Soravtansine Basic information |
| Product Name: | Soravtansine | | Synonyms: | Soravtansine;Sulfo-PDBA-DM4;Maytansine, N2'-[4-[(3-carboxy-3-sulfopropyl)dithio]-4-methyl-1-oxopentyl]-N2'-deacetyl-;Sulfo-PDBA-DM4, 98%，;4-[(4-{[(2S)-1-{[(1S,2R,3S,5S,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.11?,1?.03,?]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy}-1-oxopropan-2-yl](methyl)carbamoyl}-2-methylbutan-2-yl)disulfanyl]-2-sulfobutanoic acid;Maytansine, N2′-[4-[(3-carboxy-3-sulfopropyl)dithio]-4-methyl-1-oxopentyl]-N2′-deacetyl- (ACI) | | CAS: | 1461704-01-7 | | MF: | C42H60ClN3O15S3 | | MW: | 978.58 | | EINECS: | | | Product Categories: | | | Mol File: | 1461704-01-7.mol |  |
| | Soravtansine Chemical Properties |
| density | 1.41±0.1 g/cm3(Predicted) | | pka | 0.09±0.50(Predicted) |
| | Soravtansine Usage And Synthesis |
| Uses | Sulfo-PDBA-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Sulfo-PDBA to make antibody agent conjugate (ADC). Sulfo-PDBA is a gluthatione cleavable linker. | | IC 50 | Maytansinoids | | References | [1] Sun X, et al. Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates. Bioconjug Chem. 2017 May 17;28(5):1371-1381. DOI:10.1021/acs.bioconjchem.7b00062 |
| | Soravtansine Preparation Products And Raw materials |
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