DBCO-PEG5-NHS ester
- CAS No.
- 2144395-59-3
- Chemical Name:
- DBCO-PEG5-NHS ester
- Synonyms
- DBCO-NH-PEG5-CH2CH2COONHS;4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber:
- CB44849429
- Molecular Formula:
- C36H43N3O11
- Molecular Weight:
- 693.74
- MDL Number:
- MFCD22380747
- MOL File:
- 2144395-59-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
DBCO-PEG5-NHS ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0107985 | DBCO-PEG5-NHS ester ≥95% | 2144395-59-3 | 5mg | $195 | 2026-06-04 | Buy |
| ChemScene | CS-0107985 | DBCO-PEG5-NHS ester ≥95% | 2144395-59-3 | 10mg | $303 | 2026-06-04 | Buy |
| ChemScene | CS-0107985 | DBCO-PEG5-NHS ester ≥95% | 2144395-59-3 | 25mg | $563 | 2026-06-04 | Buy |
| ChemScene | CS-0107985 | DBCO-PEG5-NHS ester ≥95% | 2144395-59-3 | 50mg | $867 | 2026-06-04 | Buy |
| ChemScene | CS-0107985 | DBCO-PEG5-NHS ester ≥95% | 2144395-59-3 | 100mg | $1300 | 2026-06-04 | Buy |
DBCO-PEG5-NHS ester Chemical Properties,Uses,Production
Description
DBCO-PEG5-NHS Ester is a DBCO-containing PEG linker containing NHS ester that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. PEG5 spacer increases the water solubility of compounds in aqueous media. DBCO is commonly used for copper-free Click Chemistry reaction.
Biological Activity
DBCO-PEG5-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class, for the synthesis of a series of PROTAC molecules. DBCO-PEG5-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| Alkyl/ether
| PEGs
|
DBCO-PEG5-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
DBCO-PEG5-NHS ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Send Pharmaceutical Technology Co., Ltd. | 021-58088081 18317173152 | Hailey@shsendpharm.com | China | 845 | 55 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80534353 19917294565 | et@chemextension.com | China | 3904 | 55 |
| Borenpharm Co., Ltd | 027-65563561 | sales@borenpharm.com | China | 1245 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4229 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Wuhan Ruilida Biomedical Technology Co., Ltd. | 18201884268 | magean83@163.com | China | 2510 | 58 |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 13892832556 | 2440688701@qq.com | China | 1977 | 58 |
| Henan Lien Chemical Products Co., Ltd. | 0371-63357898 15378766539 | 535046669@qq.com | China | 5744 | 58 |
View Lastest Price from DBCO-PEG5-NHS ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | DBCO-PEG5-NHS
2144395-59-3
|
1g | 98% | 1g/bottle, 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | ||
 |
2026-07-17 | DBCO-PEG5-NHS ester
2144395-59-3
|
10g | TargetMol Chemicals Inc. | ||||
 |
2025-06-07 | DBCO-PEG5-NHS ester
2144395-59-3
|
50mg | >99.00% | 250mg | Xian confluore Biological Technology Co., Ltd. |
-
- DBCO-PEG5-NHS
2144395-59-3
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- DBCO-PEG5-NHS ester
2144395-59-3
- $0.00
- TargetMol Chemicals Inc.
-
- DBCO-PEG5-NHS ester
2144395-59-3
- $0.00
- >99.00%
- Xian confluore Biological Technology Co., Ltd.
