DBCO-PEG5-NHS ester manufacturers
- DBCO-PEG5-NHS
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2026-07-24
- CAS:2144395-59-3
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
- DBCO-PEG5-NHS ester
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2025-06-07
- CAS:2144395-59-3
- Min. Order: 50mg
- Purity: >99.00%
- Supply Ability: 250mg
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| | DBCO-PEG5-NHS ester Basic information |
| Product Name: | DBCO-PEG5-NHS ester | | Synonyms: | 4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester;DBCO-NH-PEG5-CH2CH2COONHS | | CAS: | 2144395-59-3 | | MF: | C36H43N3O11 | | MW: | 693.74 | | EINECS: | | | Product Categories: | | | Mol File: | 2144395-59-3.mol |  |
| | DBCO-PEG5-NHS ester Chemical Properties |
| storage temp. | -20°C, sealed storage, away from moisture and light | | solubility | Soluble in DMSO, DCM, DMF | | form | Oil | | color | Colorless to light yellow |
| | DBCO-PEG5-NHS ester Usage And Synthesis |
| Description | DBCO-PEG5-NHS Ester is a DBCO-containing PEG linker containing NHS ester that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. PEG5 spacer increases the water solubility of compounds in aqueous media. DBCO is commonly used for copper-free Click Chemistry reaction. | | Biological Activity | DBCO-PEG5-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class, for the synthesis of a series of PROTAC molecules. DBCO-PEG5-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | | in vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | | target | | Cleavable | Alkyl/ether | PEGs | |
| | DBCO-PEG5-NHS ester Preparation Products And Raw materials |
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