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Facinicline

Facinicline Structure
Facinicline structure
CAS No.
677306-35-3
Chemical Name:
Facinicline
Synonyms
R-3487;MEM-3454;RO-5313534;Facinicline;Facinicline (free base);1H-Indazole-3-carboxamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-
CBNumber:
CB44919924
Molecular Formula:
C15H18N4O
Molecular Weight:
270.33
MDL Number:
MFCD27957376
MOL File:
677306-35-3.mol
MSDS File:
SDS
Last updated:2026-05-11 19:39:08
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Facinicline Properties

Boiling point 558.8±30.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
pka 12.44±0.40(Predicted)
FDA UNII 6A6FX0J03K

Facinicline Chemical Properties, Uses, Production

Uses

Facinicline (RG3487) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM[1].

References

[1] Tanya L Wallace, et al. RG3487, a Novel Nicotinic α7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents. J Pharmacol Exp Ther. 2011 Jan;336(1):242-53. DOI:10.1124/jpet.110.171892

Facinicline Preparation Products And Raw materials

Raw materials

Preparation Products

Facinicline Suppliers

Global Suppliers ( 4)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29873 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
TargetMol Chemicals Inc. +1-781-999-5354; support@targetmol.com United States 38999 58
Supplier Advantage
BOC Sciences 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from Facinicline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Facinicline free base pictures 2026-08-15 Facinicline free base
677306-35-3
 $1520.00-2500.00 10g TargetMol Chemicals Inc.

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Facinicline Facinicline (free base) MEM-3454 R-3487 RO-5313534 1H-Indazole-3-carboxamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl- 677306-35-3