1-DODECYLIMIDAZOLE
- CAS No.
- 4303-67-7
- Chemical Name:
- 1-DODECYLIMIDAZOLE
- Synonyms
- 1-DODECYL-1H-IMIDAZOLE;C12IM;SKL1556;SKL1462;n-laurylimidazole;1-laurylimidazole;1-dodecliMidazole;N-DODECYLIMIDAZOLE;1-DODECYLIMIDAZOLE;1-dodecyl-imidazol
- CBNumber:
- CB4495420
- Molecular Formula:
- C15H28N2
- Molecular Weight:
- 236.4
- MDL Number:
- MFCD00278859
- MOL File:
- 4303-67-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Dodecyl-1H-imidazole min. 97.0 % | D6012 | 1G | $36 |
| 1-Dodecyl-1H-imidazole min. 97.0 % | D6012 | 5G | $125 |
| N-Dodecylimidazole ≥97% | 272912 | 1g | $403 |
| N-Dodecylimidazole ≥97% | 272912 | 5g | $904 |
| N-Dodecylimidazole ≥97% | 272912 | 10g | $1396 |
| More product size | |||
| Melting point | 69.5-70.5 °C(Solv: ethyl acetate (141-78-6)) |
|---|---|
| Boiling point | 146 °C (0.5 mmHg) |
| Density | 0.9624 (rough estimate) |
| vapor pressure | 0.009Pa at 20℃ |
| refractive index | 1.5312 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| pka | 7.08±0.10(Predicted) |
| color | Clear yellow |
| InChI | InChI=1S/C15H28N2/c1-2-3-4-5-6-7-8-9-10-11-13-17-14-12-16-15-17/h12,14-15H,2-11,13H2,1H3 |
| InChIKey | JMTFLSQHQSFNTE-UHFFFAOYSA-N |
| SMILES | C1N(CCCCCCCCCCCC)C=CN=1 |
| LogP | 3.56-5.5 at pH5-9 |
| Surface tension | 45mN/m at 20mg/L and 20℃ |
| FDA UNII | Q11NXV80S7 |
| EPA Substance Registry System | 1H-Imidazole, 1-dodecyl- (4303-67-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 37/39-26 |
| TSCA | TSCA listed |
| HS Code | 29332990 |
| REACH Registrations | Active |
1-DODECYLIMIDAZOLE price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D6012 | 1-Dodecyl-1H-imidazole min. 97.0 % | 4303-67-7 | 1G | $36 | 2026-04-30 | Buy |
| TCI Chemical | D6012 | 1-Dodecyl-1H-imidazole min. 97.0 % | 4303-67-7 | 5G | $125 | 2026-04-30 | Buy |
| Usbiological | 272912 | N-Dodecylimidazole ≥97% | 4303-67-7 | 1g | $403 | 2026-06-03 | Buy |
| Usbiological | 272912 | N-Dodecylimidazole ≥97% | 4303-67-7 | 5g | $904 | 2026-06-03 | Buy |
| Usbiological | 272912 | N-Dodecylimidazole ≥97% | 4303-67-7 | 10g | $1396 | 2026-06-03 | Buy |
1-DODECYLIMIDAZOLE Chemical Properties,Uses,Production
Chemical Properties
Clourless Liquid
Uses
A N-alkylated derivative of imidazole as antibacterial agent.
Synthesis
288-32-4
143-15-7
4303-67-7
Imidazole (0.68 g, 10 mmol) and bromododecane (2.5 g, 10 mmol) were added to anhydrous potassium carbonate (2.76 g, 20 mmol) in a 50 mL round-bottomed flask and dissolved in 20 mL of acetone. The mixed solution was heated to reflux for 7 hours. After completion of the reaction, the acetone solvent was removed by rotary evaporation. The crude product was purified by column chromatography using ethyl acetate as eluent. After collecting the target components, the ethyl acetate solvent was removed by rotary evaporation under reduced pressure and the final product was dried under vacuum to give purified 1-dodecylimidazole in 90% yield.
in vivo
The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase[2].
1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats[2].
| Animal Model: | Male rats[2] |
| Dosage: | 150 mg/kg body wt |
| Administration: | By stomach tube; daily for 10 days |
| Result: | Had significantly lower serum cholesterol concentrations than untreated animals. |
References
[1] Russian Journal of Organic Chemistry, 2013, vol. 49, # 9, p. 1291 - 1299
[2] Zh. Org. Khim., 2013, vol. 49, # 9, p. 1308 - 1316,9
[3] Patent: CN106188014, 2016, A. Location in patent: Paragraph 0016
[4] Patent: CN103951702, 2016, B. Location in patent: Paragraph 0059; 0060
[5] Tetrahedron, 2010, vol. 66, # 35, p. 7077 - 7082
1-DODECYLIMIDAZOLE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15083 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| henan kanbei chemical co.,ltd | +undefined-86-1523780-4566 +undefined15237804566 | henankanbeichemical@163.com | China | 511 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
View Lastest Price from 1-DODECYLIMIDAZOLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-09-20 | 1-DODECYLIMIDAZOLE
4303-67-7
|
1kg | 99% | 1000kg | henan kanbei chemical co.,ltd | ||
 |
2019-12-20 | 1-DODECYLIMIDAZOLE
4303-67-7
|
$1.00 | 1g | 99% | 1000KGS | Career Henan Chemical Co |
-
- 1-DODECYLIMIDAZOLE
4303-67-7
- $0.00
- 99%
- henan kanbei chemical co.,ltd
-
- 1-DODECYLIMIDAZOLE
4303-67-7
- $1.00
- 99%
- Career Henan Chemical Co
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