LY 303511
- CAS No.
- 154447-38-8
- Chemical Name:
- LY 303511
- Synonyms
- NV-128 (NV 128;LY303511, >=98%;LY-303511(Nv-128);LY 303511; LY303511;LY 303511, PI3-kinase inhibitor;8-phenyl-2-(piperazin-1-yl)-4H-chromen-4-one;8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one;2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 8-phenyl-2-(1-piperazinyl)-;LY 303511 dihydrochloride, Negative control for LY 294002
- CBNumber:
- CB4498214
- Molecular Formula:
- C19H18N2O2
- Molecular Weight:
- 306.36
- MDL Number:
- MFCD03453556
- MOL File:
- 154447-38-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 496.1±45.0 °C(Predicted) |
|---|---|
| Density | 1.237±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO |
| form | Amber solid |
| pka | 9.20±0.10(Predicted) |
| color | amber |
| InChI | 1S/C19H18N2O2/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13,20H,9-12H2 |
| InChIKey | NGAGMBNBKCDCDJ-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| WGK Germany | WGK 1 |
| Storage Class | 11 - Combustible Solids |
LY 303511 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 440203 | LY 303511 - CAS 154447-38-8 - Calbiochem A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002. | 154447-38-8 | 1mg | $187 | 2024-03-01 | Buy |
| Usbiological | 255723 | LY 303511 Asreported | 154447-38-8 | 5mg | $389 | 2026-06-03 | Buy |
| Biosynth | FL29540 | LY 303511 | 154447-38-8 | 1g | $2998.38 | 2026-06-04 | Buy |
| ApexBio Technology | A3568 | LY 303511 | 154447-38-8 | 5mg | $90 | 2026-05-06 | Buy |
| ApexBio Technology | A3568 | LY 303511 | 154447-38-8 | 10mg | $135 | 2026-05-06 | Buy |
LY 303511 Chemical Properties, Uses, Production
Uses
LY 303511 is an inactive analog of the phosphoinositide 3-kinase inhibitor LY294002.
Definition
ChEBI: 8-phenyl-2-(1-piperazinyl)-1-benzopyran-4-one is a N-arylpiperazine.
Biological Activity
Negative control compound with respect to LY 294004 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-onehydrochloride ) PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (K v ) channels (IC 50 = 64.6 μ M) and inhibits IL-1 β -stimulated NF- κ B activation, attenuating MCP-1 expression. Anti-proliferative.
in vivo
Intraperitoneal administration of vehicle or LY303511 (10 mg/kg/day) is performed when tumors reach a volume of ~150 mm3, at which time 35 mice have developed a tumor. After 21 days, >15% of the mice require euthanasia because of excessive tumor growth, and these data are censored due to unreliable estimates of average tumor volume. The administration of LY303511, 10 mg/kg/day, is sufficient to inhibit PC-3 tumor growth in vivo[4].
LY 303511 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| GIHI CHEMICALS CO.,LTD | 0086-571-86217390 | Sales@gihichem.com | China | 858 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2308 | 55 |
View Latest Price from LY 303511 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | LY 303511
154447-38-8
|
$2.00-5.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-07-27 | LY 303511
154447-38-8
|
$330.00-898.00 | 99.91% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-20 | LY 303511
154447-38-8
|
$1.00 | 1KG | 99% | 100kgs | Career Henan Chemical Co |
