NS 3694
- CAS No.
- 426834-38-0
- Chemical Name:
- NS 3694
- Synonyms
- NS3694, 10 mM in DMSO;Apoptosis Inhibitor II, NS3694;Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem;Benzoic acid, 4-chloro-2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;NS 3694,Inhibitor,Apaf-1,Apoptosis,inhibit,caspase-9,NS-3694,apoptosome inhibitor,NS3694,cytochrome c
- CBNumber:
- CB4498300
- Molecular Formula:
- C15H10ClF3N2O3
- Molecular Weight:
- 358.7
- MDL Number:
- MFCD00249000
- MOL File:
- 426834-38-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: 22 mg/mL, soluble |
| form | solid |
| color | Off-white to light yellow |
| InChI | 1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24) |
| InChIKey | GNCZTZCPXFDPLI-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1cc(ccc1)NC(=O)Nc2c(ccc(c2)Cl)C(=O)O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
NS 3694 price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N7787 | NS3694 ≥98%, powder | 426834-38-0 | 5mg | $114 | 2026-04-30 | Buy |
| Sigma-Aldrich | 178494 | Apoptosis Inhibitor II, NS3694 | 426834-38-0 | 10mg | $189 | 2026-04-30 | Buy |
| Cayman Chemical | 19190 | NS 3694 ≥98% | 426834-38-0 | 5mg | $72 | 2026-04-30 | Buy |
| Cayman Chemical | 19190 | NS 3694 ≥98% | 426834-38-0 | 10mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 19190 | NS 3694 ≥98% | 426834-38-0 | 25mg | $315 | 2026-04-30 | Buy |
NS 3694 Chemical Properties, Uses, Production
Description
Cytochrome c, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome. NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation. It blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC50 value of approximately 50 μM. NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1. It suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine . NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death.
Uses
NS3694 is a suppressor of the formation of apoptosome Apaf-1.
Definition
ChEBI: 4-chloro-2-[[oxo-[3-(trifluoromethyl)anilino]methyl]amino]benzoic acid is a member of ureas.
in vitro
previous study found that ns3694, and its two analogs (ns1764 and ns1784) were well-tolerated by mcf-7s1 breast cancer cells at concentrations up to 100, 50, and 25 μm, respectively. moreove, all three compounds could not inhibit recombinant caspase 9 and caspase 3 at concentrations ranging from 25 to 100 μm. in addition, ns3694 was able to inhibit the co-immunoprecipitation of caspase 9 and apaf-1 from hela cell cytosol stimulated by cytochrome c and datp. ns3694 could also inhibit the formation of the active 700-kda apoptosome complex, but had no effect on tnf-induced caspase-independent death of wehi-s cells. ns3694 did not inhibit fasl-induced caspase activation or death in type i cells neither [1].
IC 50
approximately 50 μm for cytochrome c-induced caspase activation in hela cell cytosolic extracts
References
[1] lademann, u. ,cain, k.,gyrd-hansen, m., et al. diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex. mol.cell biol. 23(21), 7829-7837 (2003).
NS 3694 Preparation Products And Raw materials
Raw materials
Preparation Products
NS 3694 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9781 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
