ChemicalBook >> CAS DataBase List >>Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate structure

CAS No.: 3641-14-3

Chemical Name:: Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate

Synonyms: ethyl 5-aMino-1H-1,2,4-triazole-3-carboxylate;Asciminib Impurity 21;5-AMINO-1H-1 2 4-TRIAZOLE-3-CARBOXYLIC;3-Amino-5-(methoxycarbonyl)-1,2,4-triazole;Methyl 5-aMino-1,2,4-triazole-3-carboxylate;Methyl 3-aMino-1,2,4-triazole-5-carboxylate;Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate;Methyl 5-aMino-2H-1,2,4-triazole-3-carboxylate;methyl 3-azanyl-1H-1,2,4-triazole-5-carboxylate;2,4-triazole-3-carboxylicacid,5-amino-1h-methylester

CBNumber:: CB4498603

Molecular Formula:: C4H6N4O2

Molecular Weight:: 142.12

MDL Number:: MFCD00297193

MOL File:: 3641-14-3.mol

MSDS File:: SDS

Last updated:2026-05-28 04:44:00

Request For Quotation

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Properties

Melting point	218-222 °C (lit.)
Boiling point	379.0±25.0 °C(Predicted)
Density	1.505±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	8.92±0.40(Predicted)
form	Crystalline Powder
color	White
InChI	InChI=1S/C4H6N4O2/c1-10-3(9)2-6-4(5)8-7-2/h1H3,(H3,5,6,7,8)
InChIKey	MGRNUMFYRVKLEO-UHFFFAOYSA-N
SMILES	N1C(N)=NC(C(OC)=O)=N1
CAS DataBase Reference	3641-14-3(CAS DataBase Reference)
FDA UNII	33BDL3S99S
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317
Precautionary statements	P280
PPE	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes	Xi
Risk Statements	43
Safety Statements	36/37
WGK Germany	3
HazardClass	IRRITANT
Storage Class	11 - Combustible Solids
Hazard Classifications	Skin Sens. 1

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	573787	5-Amino-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester 96%	3641-14-3	1g	$63.1	2026-04-30	Buy
Activate Scientific	AS33655	Methyl 5-amino-4H-[1,2,4]triazole-3-carboxylate 95%	3641-14-3	5g	$28	2026-06-04	Buy
Activate Scientific	AS33655	Methyl 5-amino-4H-[1,2,4]triazole-3-carboxylate 95%	3641-14-3	25g	$63	2026-06-04	Buy
Activate Scientific	AS33655	Methyl 5-amino-4H-[1,2,4]triazole-3-carboxylate 95%	3641-14-3	100g	$140	2026-06-04	Buy
AK Scientific	V0790	Methyl-5-amino-1H-1,2,4-triazole-3-carboxylate 98%(HPLC)	3641-14-3	1g	$16	2026-06-04	Buy

Product number	Packaging	Price	Buy
573787	1g	$63.1	Buy
AS33655	5g	$28	Buy
AS33655	25g	$63	Buy
AS33655	100g	$140	Buy
V0790	1g	$16	Buy

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Chemical Properties, Uses, Production

Synthesis

67-56-1

3-Amino-1,2,4-triazole-5-carboxylic acid

3641-13-2

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate

3641-14-3

To a solution of 5-amino-1H-1,2,4-triazole-3-carboxylic acid (3.9 g, 30.45 mmol) in methanol (100 mL) was slowly added thionyl chloride (SOCl2, 12 g, 100.84 mmol). The reaction mixture was stirred at 70 °C for 48 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The residue was dissolved in water (100 mL) and the pH was adjusted with saturated sodium bicarbonate (NaHCO3) solution to 8. Subsequently, the aqueous phase was extracted with dichloromethane (3 x 50 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford methyl 5-amino-1H-1,2,4-triazole-3-carboxylate as a white solid (800 mg, 65% yield). The product was confirmed by LC/MS (ES, m/z): [M + H]+ 143.0. 1H NMR (300 MHz, DMSO-d6): δ 3.85 (s, 3H).

References

[1] Chemical and Pharmaceutical Bulletin, 2004, vol. 52, # 2, p. 192 - 198
[2] Russian Journal of Applied Chemistry, 2006, vol. 79, # 5, p. 783 - 786
[3] Patent: WO2014/66743, 2014, A1. Location in patent: Paragraph 0146

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate synthesis

Synthesis of Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate from Methanol and 3-Amino-1,2,4-triazole-5-carboxylic acid

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Preparation Products And Raw materials

Raw materials

3-Amino-1,2,4-triazole-5-carboxylic acid Methanol

Preparation Products

3-(morpholin-4-ylcarbonyl)-1H-1,2,4-triazol-5-amine(SALTDATA: FREE) 5-amino-2H-1,2,4-triazole-3-carbohydrazide

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Suppliers

Global Suppliers ( 177)

Supplier	Tel	Email	Country	ProdList	Advantage
Tianjin Englon Technology Co., LTD	010-010-1234567 17526513758	2062435649@qq.com	China	97	49
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Ark Pharm, Inc.	847-367-3680	sales@arkpharminc.com	United States	1669	56
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Thermo Fisher Scientific	800-810-5118	cnchemical@thermofisher.com	China	17752	75
Nanjing Baifuli Technology Co., Ltd.	25-25-58740604 15951658055	sales@unisyn.cn	China	622	58

Supplier	Advantage
Tianjin Englon Technology Co., LTD	49
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Ark Pharm, Inc.	56
Beijing Ouhe Technology Co., Ltd	60
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Thermo Fisher Scientific	75
Nanjing Baifuli Technology Co., Ltd.	58

View Latest Price from Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-07-15	Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate 3641-14-3	$1.00	1KG	99%	20t	Shaanxi Dideu Medichem Co. Ltd
	2021-07-13	Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate 3641-14-3	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate
3641-14-3
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate
3641-14-3
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Spectrum

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate(3641-14-3)¹HNMR

3641-14-3 (Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate) Related Search:

Kresoxim-methyl 5-Methyl-1H-benzotriazole Methanol Methyl acrylate 1,2,4-Triazole

RESMETHRIN 1H-Benzotriazole 1,2,3-1H-Triazole Methylparaben Methyl anthranilate

RIBAVIRINA Basic Violet 1 Acetonitrile Methyl 4-aminosalicylate 1-Chloromethyl-1H-1,2,4-triazole

Methyl ethyl 5-amino-2H-1,2,4-triazole-3-carboxylate Methyl 5-amino-4H-1,2,4-triazole-3-carboxylate hydrochloride

1of4

Methyl 3-aMino-1,2,4-triazole-5-carboxylate Methyl 5-aMino-1,2,4-triazole-3-carboxylate Methyl 5-AMino-1H-1,2,4-Triazole-3-Carboxylate Sulfate Salt 5-Amino-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester 96% 1H-1,2,4-Triazole-3-carboxylicacid, 5-amino-, methyl ester 5-Amino-1H-[1, 2, 4]-triazole-3-carboxylic acid methyleester 2,4-triazole-3-carboxylicacid,5-amino-1h-methylester 5-AMINO-1H-1 2 4-TRIAZOLE-3-CARBOXYLIC Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate 3-Amino-5-(methoxycarbonyl)-1,2,4-triazole 1H-5-Amino-1,2,4-trazole-3-caboxylic acid methyl ester 5-Amino-1h-1,2,4-Triazole-3-Carboxylic Acid Methyl Ester Sulfate methyl 5-amino-1H-1,2,4-triazole-3-carboxylate hydrochloride 1H-1,2,4-triazole-3-carboxylic acid, 5-amino-, methyl este methyl 5-amino-1H-1,2,4-triazole-3-carboxylate nitrate 3-amino-1H-1,2,4-triazole-5-carboxylic acid methyl ester methyl 3-azanyl-1H-1,2,4-triazole-5-carboxylate Methyl 5-aMino-2H-1,2,4-triazole-3-carboxylate Asciminib Impurity 21 5-Amino-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester ethyl 5-aMino-1H-1,2,4-triazole-3-carboxylate 3641-14-3 Building Blocks Heterocyclic Building Blocks Triazoles Building Blocks Chemical Synthesis Heterocyclic Building Blocks