Methyl 4-iodopyridine-2-carboxylate
- CAS No.
- 380381-28-2
- Chemical Name:
- Methyl 4-iodopyridine-2-carboxylate
- Synonyms
- Methyl-ioddopicolinate;Methyl 4-iodo-2-pyridinecarboxylate;Methyl 4-iodopyridine-2-carboxylate;Methyl4-iodopyridine-2-carboxylate98%;Methyl 4-iodopyridine-2-carboxylate 98%;2-Pyridinecarboxylic acid, 4-iodo-, methyl ester;Methyl 4-iodopyridine-2-carboxylate ISO 9001：2015 REACH;METHYL 4-IODOPYRIDINE-2-CARBOXYLATE 98%METHYL 4-IODOPICOLINATE
- CBNumber:
- CB4500447
- Molecular Formula:
- C7H6INO2
- Molecular Weight:
- 263.03
- MDL Number:
- MFCD08235100
- MOL File:
- 380381-28-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xi |
| Hazard Note | Irritant/Keep Cold |
| HS Code | 2933399990 |
Methyl 4-iodopyridine-2-carboxylate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR9563 | Methyl 4-iodopyridine-2-carboxylate 98% | 380381-28-2 | 1g | $134 | 2026-06-04 | Buy |
| Apolloscientific | OR9563 | Methyl 4-iodopyridine-2-carboxylate 98% | 380381-28-2 | 5g | $441 | 2026-06-04 | Buy |
| Apolloscientific | OR9563 | Methyl 4-iodopyridine-2-carboxylate 98% | 380381-28-2 | 10g | $777 | 2026-06-04 | Buy |
| Apolloscientific | OR9563 | Methyl 4-iodopyridine-2-carboxylate 98% | 380381-28-2 | 25g | $1326 | 2026-06-04 | Buy |
| Apolloscientific | OR9563 | Methyl 4-iodopyridine-2-carboxylate 98% | 380381-28-2 | 100g | $3448 | 2026-06-04 | Buy |
Methyl 4-iodopyridine-2-carboxylate Chemical Properties, Uses, Production
Synthesis
67-56-1
405939-79-9
380381-28-2
General procedure for the synthesis of methyl 4-iodopyridine-2-carboxylate from methanol and 4-iodopyridine-2-carboxylic acid: a few drops of concentrated sulfuric acid were added to a 500 mL solution of methanol containing 5 g (13.26 mmol) of 4-iodopyridine-2-carboxylic acid. The reaction mixture was refluxed overnight. After evaporation of the solvent, the residue was purified by chromatography to afford methyl 4-iodopyridine-2-carboxylate (14a) as a yellow solid (3.0 g, 86% yield).1H NMR (300 MHz, CDCl3) δ 8.49 (d, J=1.5 Hz,1H), 8.37 (d, J=5.4 Hz,1H), 7.85 (dd, J=1.6,5.2 Hz,1H), 4.00 (s,3H); MS (ESI+): 264.3 [M+H]+. To a dry flask was added 14a (1 g, 3.8 mmol, 1 equiv), triphenylphosphine (79.7 mg, 0.3 mmol, 0.08 equiv), cuprous iodide (57.9 mg, 0.3 mmol, 0.08 equiv), palladium acetate (34.1 mg, 0.15 mmol, 0.04 equiv), and triethylamine (14 mL). The mixture was degassed with nitrogen and 3-butyn-1-ol (0.53 g, 7.6 mmol) was added and stirred at room temperature for 3 hours. The solvent was removed in vacuum to give a dark colored residue. Purification of the residue by chromatography afforded 14b (R=3-hydroxybut-1-ynyl) as a yellow oil (0.78 g, 100% yield).1H NMR (300 MHz, CDCl3) δ 8.66-8.63 (m,1H), 8.09-8.08 (m,1H), 7.43-7.40 (m,1H), 3.99 (s,3H) , 3.88-3.82 (m,2H), 2.72 (t,J=6.3Hz,2H); MS (ESI+): 206.4 [M+H]+. A solution of 14b (R=3-hydroxybut-1-ynyl) above (0.78 g, 3.8 mmol) was mixed with 10% palladium carbon (0.4 g) in 40 mL of methanol. The flask containing the reaction mixture was purged with hydrogen (1 atm) and stirred overnight at room temperature. After filtration to remove the palladium, the filtrate was concentrated to give 14c (R=3-hydroxybutyl) as an oil (0.77 g, 97% yield).1H NMR (300 MHz, CDCl3) δ 8.60 (d,J=4.5 Hz, 1H), 7.97 (d,J=1.2 Hz, 1H), 7.29 (dd,J=1.6,5.0 Hz, 1H). 3.99 (s,3H), 3.67 (t,J=6.3Hz,2H), 2.72 (t,J=7.7Hz,2H), 1.81-1.69 (m,2H), 1.62-1.54 (m,2H); MS (ESI+): 210.4 [M+H]+.
References
[1] Patent: WO2004/16632, 2004, A2. Location in patent: Page 58-59
[2] Patent: WO2013/86266, 2013, A2. Location in patent: Paragraph 00092
[3] Patent: US9533973, 2017, B2. Location in patent: Page/Page column 34-35
Methyl 4-iodopyridine-2-carboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiujiang Yulite Pharmaceutical Technology Co., Ltd. | 792-3901125 13222993784 | sales@unite-pharm.com | China | 433 | 56 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| SpringPharma Tech Co.,Ltd | +86-25-68710855, +86-25-68710897 | sales@springpharma.net | China | 1260 | 62 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Latest Price from Methyl 4-iodopyridine-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Methyl 4-iodopyridine-2-carboxylate
380381-28-2
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited |
-
- Methyl 4-iodopyridine-2-carboxylate
380381-28-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
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