2-Oxoindoline-5-sulphonyl chloride 97
- CAS No.
- 199328-31-9
- Chemical Name:
- 2-Oxoindoline-5-sulphonyl chloride 97
- Synonyms
- 5-Chlorosulfonyloxindole;2-OXOINDOLINE-5-SULP;Indolone-5-sulfonyl chloride;5-CHLOROSULPHONYL-2-OXINDOLE;5-chlorosulfonyl-2-indolinone;2-Oxindole-5-sulfonyl chloride;2-Oxindole-5-sulphonyl chloride;2-Oxindole-5-sulphonylchloride97%;2-Oxoindoline-5-sulphonyl chloride;2-Oxindole-5-sulphonyl chloride 97%
- CBNumber:
- CB4501358
- Molecular Formula:
- C8H6ClNO3S
- Molecular Weight:
- 231.66
- MDL Number:
- MFCD06655924
- MOL File:
- 199328-31-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310 | |||||||||
| Hazard Codes | C | |||||||||
| Hazard Note | Corrosive | |||||||||
| HS Code | 2933790090 | |||||||||
| NFPA 704 |
|
2-Oxoindoline-5-sulphonyl chloride 97 price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR8665 | 2-Oxindole-5-sulphonyl chloride 97% | 199328-31-9 | 100mg | $92 | 2026-06-04 | Buy |
| Apolloscientific | OR8665 | 2-Oxindole-5-sulphonyl chloride 97% | 199328-31-9 | 250mg | $131 | 2026-06-04 | Buy |
| Apolloscientific | OR8665 | 2-Oxindole-5-sulphonyl chloride 97% | 199328-31-9 | 1g | $304 | 2026-06-04 | Buy |
| Matrix Scientific | 084450 | 2-Oxoindoline-5-sulfonyl chloride | 199328-31-9 | 250.00mg | $59 | 2026-05-18 | Buy |
| Matrix Scientific | 084450 | 2-Oxoindoline-5-sulfonyl chloride | 199328-31-9 | 1.00g | $117 | 2026-05-18 | Buy |
2-Oxoindoline-5-sulphonyl chloride 97 Chemical Properties, Uses, Production
Uses
2-Oxo-5-indolinesulfonyl Chloride is a reactant used in the preparation of bis-indole-substituted pyridines and piperazinediones derivatives with potential antitumor activity. Also used in the preparation of antitumor 3,5-substituted indolin-2-one derivatives.
Synthesis
59-48-3
199328-31-9
General procedure for the synthesis of 2-oxoindoline-5-sulfonyl chloride from 2-indolone: Chlorosulfonic acid (27 mL, 408 mmol) was slowly added dropwise to indolin-2-one (13.3 g, 100 mmol) under stirring, and the dropwise acceleration was controlled to keep the reaction temperature below 30 °C. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 1.5 h, followed by warming up to 68 °C for 1 h. The reaction was then carried out at room temperature for 1.5 h. The reaction temperature was increased to 68 °C. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into water. The precipitated solid product was collected by vacuum filtration, washed with water and dried in a vacuum oven to afford 2-oxoindoline-5-sulfonyl chloride (3.02 g, 13.03 mmol, 98% yield), which can be used in subsequent reactions without further purification. The melting point of the product was 180-185 °C. 1H NMR (δ, ppm): 3.46 (s, 2H, CH2), 6.74 (d, 1H, J = 7.7 Hz, Ar), 7.42-7.46 (m, 2H, Ar), 10.48 (br s, 1H). 13C NMR (δ, ppm): 175.89, 143.68, 139.71, 124.55, 121.32, 107.39, 35.16. Elemental analysis (C8H6ClNO3S) Calculated values: C 41.48, H 2.61, N 6.05, S 13.84; measured values: C 41.57, H 2.72, N 6.14, S 13.92. S 13.92.
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 105, p. 274 - 288
[2] Journal of Antibiotics, 2018, vol. 71, # 10, p. 887 - 897
[3] Patent: CN104211632, 2016, B. Location in patent: Paragraph 0081; 0082
[4] Patent: WO2011/119777, 2011, A2. Location in patent: Page/Page column 26
[5] European Journal of Medicinal Chemistry, 2008, vol. 43, # 4, p. 755 - 762
2-Oxoindoline-5-sulphonyl chloride 97 Preparation Products And Raw materials
2-Oxoindoline-5-sulphonyl chloride 97 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Atop-Pharma (Shanghai) Technology Co., Ltd. | +86 (21) 5196-9732 | China | 996 | 57 | |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2297 | 55 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Huainan Kedi Chemical Factory | 0554-2106669 | sales1@kedichem.com | China | 4914 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 2-Oxoindoline-5-sulphonyl chloride 97 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | 2-OXOINDOLINE-5-SULPHONYL CHLORIDE 97
199328-31-9
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- 2-OXOINDOLINE-5-SULPHONYL CHLORIDE 97
199328-31-9
- $1.00
- 95-99%
- Career Henan Chemical Co
