TYRPHOSTIN AG 538
- CAS No.
- 133550-18-2
- Chemical Name:
- TYRPHOSTIN AG 538
- Synonyms
- AG 538 - CAS 133550-18-2 - Calbiochem;(E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile;(αe)-α-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-benzenepropanenitrile;Benzenepropanenitrile, α-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-, (αE)-;AG 538, (αE)-α-[(3,4-Dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-benzenepropanenitrile
- CBNumber:
- CB4505220
- Molecular Formula:
- C16H11NO5
- Molecular Weight:
- 297.26
- MDL Number:
- MFCD03453581
- MOL File:
- 133550-18-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 637.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.538±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO: 5mg/mL |
| form | solid |
| pka | 7.48±0.35(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | 974K3CXM9B |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
TYRPHOSTIN AG 538 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 658403 | AG 538 | 133550-18-2 | 5mg | $105 | 2026-04-30 | Buy |
| aablocks | AA00A1CG | AG 538 | 133550-18-2 | 1mg | $87 | 2026-05-28 | Buy |
| aablocks | AA00A1CG | AG 538 | 133550-18-2 | 5mg | $183 | 2026-05-28 | Buy |
| aablocks | AA00A1CG | AG 538 | 133550-18-2 | 10mg | $266 | 2026-05-28 | Buy |
| aablocks | AA00A1CG | AG 538 | 133550-18-2 | 25mg | $452 | 2026-05-28 | Buy |
TYRPHOSTIN AG 538 Chemical Properties, Uses, Production
Uses
AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM[1].
Definition
ChEBI: 3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphenyl)-oxomethyl]-2-propenenitrile is a member of chalcones.
Biological Activity
Cell permeable: yes', 'Primary Target
IGF-1 receptor kinase', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 400 nM against IGF-1 receptor kinase
References
[1] G Blum, et al. Substrate Competitive Inhibitors of IGF-1 Receptor Kinase. Biochemistry. 2000 Dec 26;39(51):15705-12. DOI:10.1021/bi001516y
TYRPHOSTIN AG 538 Preparation Products And Raw materials
Raw materials
Preparation Products
TYRPHOSTIN AG 538 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
View Latest Price from TYRPHOSTIN AG 538 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Tyrphostin AG 538
133550-18-2
|
$83.00-307.00 | 99.73% | 10g | TargetMol Chemicals Inc. |
-
- Tyrphostin AG 538
133550-18-2
- $83.00-307.00
- 99.73%
- TargetMol Chemicals Inc.
