2-Chloro-3-hydroxybenzaldehyde 97
- CAS No.
- 56962-10-8
- Chemical Name:
- 2-Chloro-3-hydroxybenzaldehyde 97
- Synonyms
- 2-chloro-3-hydroxy-;Benzaldehyde, 2-chloro-3-hydroxy-;2-Chloro-3-hydroxybenzaldehyde 97;2-Chloro-3-hydroxybenzaldehyde 97%
- CBNumber:
- CB4505396
- Molecular Formula:
- C7H5ClO2
- Molecular Weight:
- 156.57
- MDL Number:
- MFCD06798118
- MOL File:
- 56962-10-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 139-143 °C (lit.) |
|---|---|
| Boiling point | 245.0±20.0 °C(Predicted) |
| Density | 1.404±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 7.77±0.10(Predicted) |
| form | solid |
| color | Off-white to faint orange |
| InChI | 1S/C7H5ClO2/c8-7-5(4-9)2-1-3-6(7)10/h1-4,10H |
| InChIKey | SEEAPLJEIJXFFU-UHFFFAOYSA-N |
| SMILES | [H]C(=O)c1cccc(O)c1Cl |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H318-H335-H400 |
| Precautionary statements | P273-P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn,N |
| Risk Statements | 22-37/38-41-50 |
| Safety Statements | 26-36-60-61 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 2 |
| HazardClass | 9 |
| PackingGroup | Ⅲ |
| HS Code | 2913000090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
| Limited Quantities | 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
2-Chloro-3-hydroxybenzaldehyde 97 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 647365 | 2-Chloro-3-hydroxybenzaldehyde 97% | 56962-10-8 | 1g | $57 | 2023-01-07 | Buy |
| Sigma-Aldrich | 647365 | 2-Chloro-3-hydroxybenzaldehyde 97% | 56962-10-8 | 10g | $248 | 2023-01-07 | Buy |
| Apolloscientific | OR939587 | 2-Chloro-3-hydroxybenzaldehyde 97% | 56962-10-8 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR939587 | 2-Chloro-3-hydroxybenzaldehyde 97% | 56962-10-8 | 5g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR939587 | 2-Chloro-3-hydroxybenzaldehyde 97% | 56962-10-8 | 25g | $104 | 2026-06-04 | Buy |
2-Chloro-3-hydroxybenzaldehyde 97 Chemical Properties, Uses, Production
Uses
2-chloro-3-hydroxy-Benzaldehyde is a versatile building block used in the preparation of positional isomers of NOSH-aspirin a dual nitric oxide and hydrogen sulfide releasing hybrid pharmaceutical.
Synthesis
100-83-4
56962-10-8
Under stirring conditions, tBuOCl (20 mL, 176 mmol) was slowly added dropwise to a suspension of 3-hydroxybenzaldehyde (20.12 g, 160 mmol) in HOAc (40 mL). The reaction solution gradually changed to a clarified solution with significant exothermic phenomenon. The reaction mixture was cooled and stirred continuously for 16 h, during which a white precipitate was generated. The solid product was collected by filtration, washed with deionized water and dried to afford 2-chloro-3-hydroxybenzaldehyde (13.77 g, 55% yield), which was analyzed by GCMS (EI) showing m/z 156,158 (M+). Subsequently, 2-chloro-3-hydroxybenzaldehyde (4.55 g, 29 mmol) was dissolved in DMF (30 mL), and K2CO3 (4.8 g, 34.9 mmol) and MeI (2.7 mL, 43.6 mmol) were added sequentially, and the reaction was stirred for 16 h at room temperature. After the reaction was completed, the solvent was removed by distillation under reduced pressure, and the residue was dissolved with ethyl acetate, washed with water and saturated saline in turn, dried over anhydrous Na2SO4 and concentrated. Purification was carried out by silica gel column chromatography with ethyl acetate/hexane (1:5) as eluent to obtain 2-chloro-3-methoxybenzaldehyde 3a (4.68 g, 94% yield) as a colorless oil, which was solidified after standing.GCMS (EI) analysis showed m/z 170,172 (M+).
References
[1] ACS Catalysis, 2018, vol. 8, # 5, p. 4033 - 4043
[2] Australian Journal of Chemistry, 2005, vol. 58, # 8, p. 565 - 571
[3] Patent: WO2005/7164, 2005, A1. Location in patent: Page 30-31
[4] Patent: WO2005/7165, 2005, A1. Location in patent: Page 46
[5] Patent: WO2005/7633, 2005, A1. Location in patent: Page 33
2-Chloro-3-hydroxybenzaldehyde 97 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 |
View Latest Price from 2-Chloro-3-hydroxybenzaldehyde 97 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2-CHLORO-3-HYDROXYBENZALDEHYDE 97
56962-10-8
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 2-CHLORO-3-HYDROXYBENZALDEHYDE 97
56962-10-8
- $1.00
- 98%
- Career Henan Chemical Co
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