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Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy-

Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- structure

CAS No.: 1604821-43-3

Chemical Name:: Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy-

Synonyms: Lipid Uptake Inhibitor, ML278;Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy-

CBNumber:: CB45488498

Molecular Formula:: C23H23N3O5S

Molecular Weight:: 453.51

MDL Number:

MOL File:: 1604821-43-3.mol

Last updated:2026-01-13 13:16:50

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Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- Properties

Density	1.339±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 5mg/mL
pka	6.84±0.50(Predicted)
form	solid
color	light yellow
UNSPSC Code	12352211
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0015973	ML278	1604821-43-3	5mg	$439	2026-06-04	Buy
ChemScene	CS-0015973	ML278	1604821-43-3	10mg	$704	2026-06-04	Buy
ChemScene	CS-0015973	ML278	1604821-43-3	25mg	$1403	2026-06-04	Buy
ChemScene	CS-0015973	ML278	1604821-43-3	50mg	$2248	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0015973	5mg	$439	Buy
CS-0015973	10mg	$704	Buy
CS-0015973	25mg	$1403	Buy
CS-0015973	50mg	$2248	Buy

Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- Chemical Properties, Uses, Production

Uses

A cell-permeable, non-toxic, indolinyl-thiazole based compound that acts as a highly potent, reversible inhibitor of lipid uptake via scavenger receptor class B type I (SR-BI; IC₅₀ = 6 nM). Shown to block the uptake of [³H] labeled cholesteryl oleate ester ([³H]CE) from [³H]CE-HDL (IC₅₀ = 7 nM). Exhibits high selectivity when tested against a panel of 67 different receptors and secondary targets (at 10 µM). Displays excellent stability in human plasma (99% remaining after 5 h, with 94% plasma protein bound) and mouse liver microsomes (75% remaining after 1 h).
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biological Activity

Cell permeable: yes', 'Primary Target
scavenger receptor class B type I', 'Reversible: yes

Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
Merck KGaA	--	ordercn@merckgroup.com	China	6376	58

Supplier	Advantage
Merck KGaA	58

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Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- Lipid Uptake Inhibitor, ML278 1604821-43-3