6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride
- CAS No.
- 1376162-36-5
- Chemical Name:
- 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride
- Synonyms
- C1s-IN-1 (trihydrochloride);6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride
- CBNumber:
- CB45858455
- Molecular Formula:
- C16H20ClN5
- Molecular Weight:
- 317.82
- MDL Number:
- MOL File:
- 1376162-36-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 |
6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BFC16236 | 6-(4-Phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride | 1376162-36-5 | 50mg | $323.5 | 2026-06-04 | Buy |
| Biosynth | BFC16236 | 6-(4-Phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride | 1376162-36-5 | 0.5g | $1109.2 | 2026-06-04 | Buy |
| ChemScene | CS-0481924 | C1s-IN-1 (trihydrochloride) ≥98% | 1376162-36-5 | 100mg | $123 | 2026-06-04 | Buy |
| ChemScene | CS-0481924 | C1s-IN-1 (trihydrochloride) ≥98% | 1376162-36-5 | 250mg | $204 | 2026-06-04 | Buy |
| ChemScene | CS-0481924 | C1s-IN-1 (trihydrochloride) ≥98% | 1376162-36-5 | 1g | $541 | 2026-06-04 | Buy |
6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride Chemical Properties, Uses, Production
Uses
C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 μM[1].
References
[1] Xu X, et al., Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol. 2024 Feb 15;212(4):689-701. DOI:10.4049/jimmunol.2300630
6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39718 | 58 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
| Zhejiang Huida Biotech Co., Ltd. | 0571-89903022 18679456698 | zilong@hizyme.com | China | 7853 | 58 |
