2-Chloromandelic acid
- CAS No.
- 10421-85-9
- Chemical Name:
- 2-Chloromandelic acid
- Synonyms
- 2-(2-CHLOROPHENYL)-2-HYDROXYACETIC ACID;TIMTEC-BB SBB003705;2-Chloromandelic aci;2-CHLOROMANDELIC ACID;o-chloromandelic acid;Chloromandelic Acid DL-;DL- Chloromandelic acid;DL-2-CHLOROMANDELIC ACID;Orthochloromandelic acid;2-Chloromandelic acid,98%
- CBNumber:
- CB4680112
- Molecular Formula:
- C8H7ClO3
- Molecular Weight:
- 186.59
- MDL Number:
- MFCD00084962
- MOL File:
- 10421-85-9.mol
- MSDS File:
- SDS
| Melting point | 90-93 °C(lit.) |
|---|---|
| Boiling point | 266.91°C (rough estimate) |
| Density | 1.3245 (rough estimate) |
| refractive index | 1.5250 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 3.30±0.10(Predicted) |
| color | White to pale cream |
| Water Solubility | Very soluble in water. |
| BRN | 2367070 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C8H7ClO3/c9-6-4-2-1-3-5(6)7(10)8(11)12/h1-4,7,10H,(H,11,12) |
| InChIKey | RWOLDZZTBNYTMS-UHFFFAOYSA-N |
| SMILES | C(C1C=CC=CC=1Cl)(O)C(=O)O |
| CAS DataBase Reference | 10421-85-9(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29181990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
2-Chloromandelic acid price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 530182 | 2-Chloromandelic acid 98% | 10421-85-9 | 5g | $173 | 2026-04-30 | Buy |
| TCI Chemical | C3937 | 2-(2-Chlorophenyl)-2-hydroxyacetic Acid min. 98.0 % | 10421-85-9 | 25G | $43 | 2026-04-30 | Buy |
| TCI Chemical | C3937 | 2-(2-Chlorophenyl)-2-hydroxyacetic Acid min. 98.0 % | 10421-85-9 | 100G | $128 | 2026-04-30 | Buy |
| TRC | TRC-C432673-5G | 2-Chloromandelic acid | 10421-85-9 | 5g | $62 | 2026-06-03 | Buy |
| TRC | TRC-C432673-50G | 2-Chloromandelic acid | 10421-85-9 | 50g | $101 | 2026-06-03 | Buy |
2-Chloromandelic acid Chemical Properties, Uses, Production
Chemical Properties
White to pale cream crystalline powder
Uses
2-Chloromandelic acid, is used as a pharmaceutical intermediate as well as in the medicine industry. It is used as a intermediate of clopidrogrel.
General Description
2-Chloromandelic acid (2-ClMA) is a mandelic acid derivative. A report based on its solid state-NMR, X-ray powder diffraction (XPRD) and Fourier transform infrared spectroscopy (FTIR) data reveals that in solid state 2-ClMA exists as a racemic compound. The study also suggests that the crystals of racemic 2-ClMA belongs the monoclinic space group P21/c. The efficiency of (R)-(+)-N-benzyl-1-phenylethylamine in resolving racemate 2-ClMA has been investigated.
Synthesis
74-90-8
89-98-5
10421-85-9
52923-20-3
First, 150 mL of toluene was added to a flask equipped with a stirrer and an internal thermometer. Under stirring conditions, 0.09 g (0.08 x 10^-3 mol) of the (R,R)-VO salen complex from Example 1 and 21.1 g (0.15 mol) of freshly prepared 2-chlorobenzaldehyde were added sequentially. Subsequently, 10.1 g (0.375 mol) of hydrocyanic acid was added all at once. The resulting dark green homogeneous solution was stirred for 24 h at room temperature in a closed apparatus. The conversion was analyzed by gas chromatography (GC) to be 98% and the enantiomeric excess (ee) value of (S)-2-chloromandelate cyanohydrin was 73%.
References
[1] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
2-Chloromandelic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Jintan Kuncheng Biotechnology Co., Ltd | 13814785958 | 772059499@qq.com | China | 73 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Latest Price from 2-Chloromandelic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 2-Chloromandelic acid
10421-85-9
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-06-27 | 2-Chloromandelic acid
10421-85-9
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2025-04-04 | 2-Chloromandelic acid
10421-85-9
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2-Chloromandelic acid
10421-85-9
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Chloromandelic acid
10421-85-9
- $0.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Chloromandelic acid
10421-85-9
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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