3-Amino-4-iodobenzotrifluoride
- CAS No.
- 105202-02-6
- Chemical Name:
- 3-Amino-4-iodobenzotrifluoride
- Synonyms
- 3-AMINO-4-IODOBENZOTRIFLUORIDE;3-Amino-4-iodobenzotrifluoride98%;3-Amino-4-iodobenzotrifluoride 98%;Benzenamine, 2-iodo-5-(trifluoromethyl)-;2-Iodo-5-(trifluoromethyl)aniline【3-Amino-4-iodobenzotrifluoride】;3-AMino-4-iodobenzotrifluoride[2-Iodo-5-(trifluoroMethyl)aniline];2-Iodo-5-(trifluoromethyl)aniline, 6-Iodo-alpha,alpha,alpha-trifluoro-m-toluidine
- CBNumber:
- CB4695044
- Molecular Formula:
- C7H5F3IN
- Molecular Weight:
- 287.02
- MDL Number:
- MFCD04972658
- MOL File:
- 105202-02-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36/37/39 |
| Hazard Note | Irritant |
| HS Code | 2921490090 |
3-Amino-4-iodobenzotrifluoride price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC2015 | 3-Amino-4-iodobenzotrifluoride 98% | 105202-02-6 | 500mg | $59 | 2026-06-04 | Buy |
| Apolloscientific | PC2015 | 3-Amino-4-iodobenzotrifluoride 98% | 105202-02-6 | 1g | $67 | 2026-06-04 | Buy |
| Apolloscientific | PC2015 | 3-Amino-4-iodobenzotrifluoride 98% | 105202-02-6 | 5g | $108 | 2026-06-04 | Buy |
| Apolloscientific | PC2015 | 3-Amino-4-iodobenzotrifluoride 98% | 105202-02-6 | 10g | $198 | 2026-06-04 | Buy |
| Apolloscientific | PC2015 | 3-Amino-4-iodobenzotrifluoride 98% | 105202-02-6 | 25g | $468 | 2026-06-04 | Buy |
3-Amino-4-iodobenzotrifluoride Chemical Properties, Uses, Production
Chemical Properties
colorless to light yellow liquid
Uses
3-Amino-4-iodobenzotrifluoride is a useful intermediate for the preparation of trifluoromethylindoles by coupling-annulation of alkynes with iodo(trifluoromethyl)anilines.
Synthesis
400-97-5
105202-02-6
General procedure for the synthesis of 2-iodo-5-trifluoromethylaniline from 3-nitro-4-iodobenzotrifluoride: Iron powder (750 mg, 13.43 mmol) was added to a mixed HOAc-EtOH solution (10 mL, 1:5, v/v) of 3-nitro-4-iodobenzotrifluoride (850 mg, 2.68 mmol) at 23 °C. The reaction mixture was stirred at 23 °C for 3 h. The reaction was subsequently quenched with saturated NaHCO3 solution (20 mL) and diluted with EtOAc (50 mL). The organic and aqueous layers were separated and the organic layer was washed with deionized water (3 x 10 mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel as stationary phase, eluent hexane:EtOAc, 10:1, v/v) to afford 2-iodo-5-trifluoromethylaniline (754 mg, 98% yield) as a yellow solid.1H NMR (400 MHz, CDCl3) δ = 7.76 (dd, J = 8.2,0.7Hz, 1H), 6.96 (d, J = 1.7 Hz, 1H), 6.72 (ddd, J=8.2,2.0,0.6 Hz, 1H), 4.32 (brs, 2H). Mass spectrum (ESI) m/z: 288.0 [M+H]+.
References
[1] Patent: WO2016/29310, 2016, A1. Location in patent: Paragraph 00357-00359
[2] Patent: US5079245, 1992, A
[3] Angewandte Chemie - International Edition, 2011, vol. 50, # 32, p. 7354 - 7358
[4] Patent: US5998334, 1999, A
[5] Organic Letters, 2017, vol. 19, # 17, p. 4484 - 4487
3-Amino-4-iodobenzotrifluoride Preparation Products And Raw materials
3-Amino-4-iodobenzotrifluoride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Wuhan Arike Technology Co., Ltd. | 027- 51832457 94518350 | China | 746 | 62 | |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3833 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 3-Amino-4-iodobenzotrifluoride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-02-02 | 3-Amino-4-iodobenzotrifluoride
105202-02-6
|
10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
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- 3-Amino-4-iodobenzotrifluoride
105202-02-6
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
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