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2-Amino-4-chloro-6-methoxypyrimidine

2-Amino-4-chloro-6-methoxypyrimidine structure

CAS No.: 5734-64-5

Chemical Name:: 2-Amino-4-chloro-6-methoxypyrimidine

Synonyms: ACMP;2-Pyrimidinamine, 4-chloro-6-methoxy-;4-CHLORO-6-METHOXY-PYRIMIDIN-2-YLAMINE;TIMTEC-BB SBB003975;2-amino-4-chloro-6-methoxypyri;2-Amino-4-methoxy-6-chloropyri;4-chloro-6-methoxy-2-pyrimidinamin;2-AMino-4-chloro-6-MethylyriMidine;4-Chloro-6-methoxy-2-pyrimidinamine;2-amino-4-chloro-6-methoxypyrimidne

CBNumber:: CB4707363

Molecular Formula:: C5H6ClN3O

Molecular Weight:: 159.57

MDL Number:: MFCD00233535

MOL File:: 5734-64-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:29:29

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2-Amino-4-chloro-6-methoxypyrimidine Properties

Melting point	168-171 °C (lit.)
Boiling point	349.4±45.0 °C(Predicted)
Density	1.6625 (rough estimate)
refractive index	1.4510 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	1.96±0.10(Predicted)
form	Crystalline Powder
color	Light yellow
InChI	1S/C5H6ClN3O/c1-10-4-2-3(6)8-5(7)9-4/h2H,1H3,(H2,7,8,9)
InChIKey	VFEYBTFCBZMBAU-UHFFFAOYSA-N
SMILES	COc1cc(Cl)nc(N)n1
CAS DataBase Reference	5734-64-5(CAS DataBase Reference)
EWG's Food Scores	1
EPA Substance Registry System	2-Pyrimidinamine, 4-chloro-6-methoxy- (5734-64-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312a-P330-P501a

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

Safety Statements

22-2

WGK Germany

RTECS

UV6260335

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29335990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

REACH Registrations

Inactive

NFPA 704

	1
2		0

2-Amino-4-chloro-6-methoxypyrimidine price More Price(65)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	518646	2-Amino-4-chloro-6-methoxypyrimidine 95%	5734-64-5	10g	$55.9	2023-06-20	Buy
Sigma-Aldrich	518646	2-Amino-4-chloro-6-methoxypyrimidine 95%	5734-64-5	50g	$164	2023-06-20	Buy
TCI Chemical	A1520	2-Amino-4-chloro-6-methoxypyrimidine >95.0%(HPLC)(T)	5734-64-5	5g	$19	2026-04-30	Buy
TCI Chemical	A1520	2-Amino-4-chloro-6-methoxypyrimidine >95.0%(HPLC)(T)	5734-64-5	25g	$23	2026-04-30	Buy
Usbiological	295304	2-Amino-6-chloro-4-methoxypyrimidine Asreported	5734-64-5	5g	$275	2026-06-03	Buy

Product number	Packaging	Price	Buy
518646	10g	$55.9	Buy
518646	50g	$164	Buy
A1520	5g	$19	Buy
A1520	25g	$23	Buy
295304	5g	$275	Buy

2-Amino-4-chloro-6-methoxypyrimidine Chemical Properties, Uses, Production

Chemical Properties

light yellow crystalline powder

Uses

2-Amino-4-chloro-6-methoxy-pyrimidine is one of the two major metabolites formed in the degradation of chlorimuron-ethyl; a pre- and post-emergence herbicide for the control of important broad-leaved weeds in soybean and maize.

Synthesis

67-56-1

56-05-3

5734-64-5

GENERAL PROCEDURE: Intermediate Id-f was prepared similarly to Intermediate Ia-c. Anhydrous tetrahydrofuran (12 mL) solution of sodium hydride (5.8 mmol) was cooled to 0 °C under nitrogen protection, followed by slow dropwise addition of substitutional alcohol (6.1 mmol). The reaction mixture was kept stirred at 0 °C for 15 min. Then, 2-amino-4,6-dichloropyrimidine (5.8 mmol) was added to the reaction system. The reaction temperature was raised to 62°C and the reaction was continued for 15 hours. After completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with 1 M hydrochloric acid solution (1 mL). The reaction mixture was diluted with ethyl acetate (20 mL), washed twice sequentially with saturated sodium bicarbonate solution (20 mL) and brine (20 mL), and the organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether as eluent) to afford the target compound Id-f. 4-Chloro-6-methoxypyrimidin-2-amine (Id) was a white solid with a melting point of 165-167 °C in 84% yield.1H-NMR (CDCl3) δ 6.04 (s, 1H, ArH), 5.35-5.14 (m, 2H , NH2), 3.81 (s, 3H, OCH3).

References

[1] Patent: WO2004/37795, 2004, A1. Location in patent: Page/Page column 8
[2] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 10, p. 774 - 779
[3] Molecules, 2018, vol. 23, # 9,
[4] Nippon Kagaku Zasshi, 1953, vol. 74, p. 624
[5] Chem.Abstr., 1954, p. 13693

2-Amino-4-chloro-6-methoxypyrimidine Preparation Products And Raw materials

Raw materials

Methanol 2-Amino-4,6-dichloropyrimidine Sodium Methoxide Sodium hydride Tetrahydrofuran

Preparation Products

2-Amino-4-chloro-6-methoxypyrimidine Suppliers

Global Suppliers ( 361)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Ark Pharm, Inc.	847-367-3680	sales@arkpharminc.com	United States	1669	56
Beijing dtftchem Technology Co., Ltd.	010-60275820 13031183356	elainezt@sina.com	China	1386	62
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Ark Pharm, Inc.	56
Beijing dtftchem Technology Co., Ltd.	62
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60

View Latest Price from 2-Amino-4-chloro-6-methoxypyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	2-Amino-4-chloro-6-methoxypyrimidine 5734-64-5	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-06-25	2-Amino-4-chloro-6-methoxypyrimidine 5734-64-5	$1.10	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	2-Amino-4-chloro-6-methoxypyrimidine 5734-64-5	$1.00	1KG	98%	100KG	Career Henan Chemical Co

2-Amino-4-chloro-6-methoxypyrimidine
5734-64-5
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Amino-4-chloro-6-methoxypyrimidine
5734-64-5
$1.10
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2-Amino-4-chloro-6-methoxypyrimidine
5734-64-5
$1.00
98%
Career Henan Chemical Co

2-Amino-4-chloro-6-methoxypyrimidine Spectrum

2-Amino-4-chloro-6-methoxypyrimidine(5734-64-5)¹HNMR

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1of4

2-AMINO-4-CHLORO-6-METHOXYPYRIMIDINE 2-AMINO-4-METHOXY-6-CHLORO PYRIMIDINE 2-AMINO-6-CHLORO-4-METHOXYPYRIMIDINE 4-Chloro-6-methoxy-2-pyrimidinamine 4-CHLORO-6-METHOXY-2-PYRIMIDINYLAMINE 4-CHLORO-6-METHOXY-PYRIMIDIN-2-AMINE 4-chloro-6-methoxy-2-pyrimidinamin 4-methoxy-6-chloro-2-aminopyrimidine 2-amino-4-Chlorine-6-methoxypyrimidine 2-Amino-4-chloro-6-methoxylpyrimidine TIMTEC-BB SBB003975 2-amino-4-chloro-6-methoxypyri 2-Amino-4-methoxy-6-chloropyri 2-AMINO-4-CHLORO-6-METHOXYPYRIMIDINE(2-AMINO-4-METHOXY-6-CHLOROPYRIMIDINE) 2-amino-4-chloro-6-methoxypyrimidne 2-AMINO-4-CHLORO-6-METHOXYPYRIMIDINE 97% 2-Amino-4-chloro-6-methoxypyrimidine ,98% 6-Chloro-4-methoxypyrimidine-2-amine 2-Amino-6-chloro-4-methoxypyrimidine,98% 2-Amino-4-chloro-6-methoxypyrimidine,95% 2-AMino-4- chloro-6-MethoxypyriMidine , 4-Chloro-6-Methoxy-2-pyriMidinaMine 2-Pyrimidinamine, 4-chloro-6-methoxy- 2-AMino-4-chloro-6-MethylyriMidine 4-Chloro-6-methoxypyrimidin-2-amine, 2-Amino-4-chloro-6-methoxy-1,3-diazine 2-Amino-4-chloro-6-methoxypyrimidine > 2-Amino-4-chloro-6-methoxypyrimidine ISO 9001：2015 REACH 4-Chloro-6-methoxypyrimidin-2-amine - [C71535] 4-CHLORO-6-METHOXY-PYRIMIDIN-2-YLAMINE ACMP 5734-64-5 5743-64-5 C5H6N3OCl C5H6ClN3O Building Blocks Pyrimidines Heterocyclic Building Blocks Halogenated Heterocycles Heterocycle-Pyrimidine series Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks Pyrimidines Pyrimidine Pyridines, Pyrimidines, Purines and Pteredines