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2-Amino-4,6-dichloropyrimidine

2-Amino-4,6-dichloropyrimidine Structure
2-Amino-4,6-dichloropyrimidine structure
CAS No.
56-05-3
Chemical Name:
2-Amino-4,6-dichloropyrimidine
Synonyms
4,6-DICHLOROPYRIMIDIN-2-AMINE;ADCP;2-PYRIMIDINAMINE, 4,6-DICHLORO-;py11;AKOS 90013;oropyrimidine;2-Amino-4,6-dichL;TIMTEC-BB SBB003919;6-dichloropyriMidine;LABOTEST-BB LT00080771
CBNumber:
CB3128097
Molecular Formula:
C4H3Cl2N3
Molecular Weight:
163.99
MDL Number:
MFCD00006090
MOL File:
56-05-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:56:34
Product description Number Pack Size Price
2-Amino-4,6-dichloropyrimidine 98% A48601 10G $129
2-Amino-4,6-dichloropyrimidine 98% A48601 100G $305
2-Amino-4,6-dichloropyrimidine >98.0%(N) A1110 25g $69
2-Amino-4,6-dichloropyrimidine >95.0%(N) A1456 25g $89
2-Amino-4,6-dichloropyrimidine Asreported 258431 100g $307
More product size
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2-Amino-4,6-dichloropyrimidine Properties

Melting point 219-222 °C (lit.)
Boiling point 219-222°C
Density 1.6662 (rough estimate)
refractive index 1.6300 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka 0.14±0.10(Predicted)
form Liquid
color Clear colorless to light yellow
Water Solubility Insoluble in water, soluble in acetone, two monomer (VCM) and thermal toluene.
BRN 118454
InChI InChI=1S/C4H3Cl2N3/c5-2-1-3(6)9-4(7)8-2/h1H,(H2,7,8,9)
InChIKey JPZOAVGMSDSWSW-UHFFFAOYSA-N
SMILES C1(N)=NC(Cl)=CC(Cl)=N1
CAS DataBase Reference 56-05-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 885F759P8I
EPA Substance Registry System 2-Pyrimidinamine, 4,6-dichloro- (56-05-3)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
RTECS  UV6260485
F  10
TSCA  TSCA listed
HazardClass  IRRITANT
HS Code  29335995
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
1 0

2-Amino-4,6-dichloropyrimidine price More Price(87)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A48601 2-Amino-4,6-dichloropyrimidine 98% 56-05-3 10G $129 2026-04-30 Buy
Sigma-Aldrich A48601 2-Amino-4,6-dichloropyrimidine 98% 56-05-3 100G $305 2026-04-30 Buy
TCI Chemical A1110 2-Amino-4,6-dichloropyrimidine >98.0%(N) 56-05-3 25g $69 2026-04-30 Buy
TCI Chemical A1456 2-Amino-4,6-dichloropyrimidine >95.0%(N) 56-05-3 25g $89 2023-06-20 Buy
Usbiological 258431 2-Amino-4,6-dichloropyrimidine Asreported 56-05-3 100g $307 2026-06-03 Buy
Product number Packaging Price Buy
A48601 10G $129 Buy
A48601 100G $305 Buy
A1110 25g $69 Buy
A1456 25g $89 Buy
258431 100g $307 Buy

2-Amino-4,6-dichloropyrimidine Chemical Properties,Uses,Production

Chemical Properties

LIGHT BROWN CRYSTALLINE POWDER

Uses

Microwave-assisted synthesis of pyrazolo [3, 4-d] pyrimidines from 2-amino-4, 6-dichloropyrimidine-5-carbaldehyde is under solvent-free conditions. A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(PPh3)2Cl2 as catalyst.

Synthesis

2-Amino-4,6-dihydroxypyrimidine

56-09-7

2-Amino-4,6-dichloropyrimidine

56-05-3

The general procedure for the synthesis of 2-amino-4,6-dichloropyrimidine from 2-amino-4,6-dihydroxypyrimidine is as follows: in a four-necked flask equipped with a reflux condenser, 510 g of 2-amino-4,6-dihydroxypyrimidine (98% purity, 4 mol) and 1428 g of phosphorus triclosan (99% purity) were added, heated and stirred. 810 g of triethylamine (99% purity) was slowly added dropwise at 40 to 45 °C through a constant pressure dropping funnel. After the dropwise addition, the reaction temperature was raised to 85 to 90 °C and maintained at this temperature for 2 hours. The progress of the reaction was monitored by high performance liquid chromatography (HPLC) and the reaction was considered complete when the amount of 2-amino-4,6-dihydroxypyrimidine was less than 1%. Subsequently, 3000 g of toluene was added to the reaction mixture, cooled to 0-10°C, and 3000 g of ice-water mixture was added for low temperature hydrolysis. The mixture was then warmed to room temperature and left to stratify. The aqueous layer was extracted twice with 400 g of toluene, and the organic phases were combined and washed sequentially with aqueous sodium carbonate and water until neutral. The organic phase was concentrated and 1800 g of toluene was recovered to give 2668 g of highly concentrated toluene solution. The product was analyzed by HPLC, the purity was 96.8%, the content was 22.58% (external standard method), and the yield of crude product was 92%.

References

[1] Patent: CN108395409, 2018, A. Location in patent: Paragraph 0046-0047; 0050
[2] Organic Letters, 2009, vol. 11, # 1, p. 61 - 64
[3] Chemical Communications, 2017, vol. 53, # 18, p. 2689 - 2692
[4] Organic and Biomolecular Chemistry, 2017, vol. 15, # 47, p. 10087 - 10094
[5] Tetrahedron Letters, 2015, vol. 56, # 10, p. 1179 - 1182

2-Amino-4,6-dichloropyrimidine Preparation Products And Raw materials

Raw materials

4,6-Dihydroxypyrimidine Triethylamine 2-Amino-4,6-dihydroxypyrimidine

Preparation Products

Bensulfuron methyl 2-Amino-4,6-dimethoxypyrimidine 2-AMINO-4-HYDROXY-6-HYDRAZINOPYRIMIDINE 4-(4,6-Dichloropyrimidin-2-yl)morpholine 4-chloro-6-(2,3-dichlorophenyl)pyrimidin-2-amine
6-Chloro-N~4~-ethylpyrimidine-2,4-diamine 2-AMINO-4-HYDROXY-6-IODOPYRIMIDINE 5-ETHYLCYCLOHEXANE-1,3-DION 2-AMINO-4-CHLORO-6-GUANIDINOPYRIMIDINE 4-Chloro-6-hydrazinylpyrimidin-2-amine
2-Amino-4,6-dimercaptopyrimidine N4,N6-dimethyl-pyrimidine-2,4,6-triamine 4-CHLORO-6-MORPHOLIN-4-YLPYRIMIDIN-2-AMINE

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2-Amino-4,6-dichloropyrimidine Suppliers

Global( 531)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5223 58
Jiangsu Liyang Kunlun Biological Technology Co., Ltd. 		+86-13813530041 z13813530041@126.com China 337 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21585 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Jiangsu Liyang Kunlun Biological Technology Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58

View Lastest Price from 2-Amino-4,6-dichloropyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-4,6-dichloropyrimidine pictures 2026-05-28 2-Amino-4,6-dichloropyrimidine
56-05-3
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
2-Amino-4,6-dichloropyrimidine pictures 2026-03-20 2-Amino-4,6-dichloropyrimidine
56-05-3
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Amino-4,6-dichloropyrimidine pictures 2025-04-02 2-Amino-4,6-dichloropyrimidine
56-05-3
 5000kg 0.99 50 tons Jiangsu Liyang Kunlun Biological Technology Co., Ltd.

2-Amino-4,6-dichloropyrimidine Spectrum

2-Amino-4,6-dichloropyrimidine(56-05-3)MS2-Amino-4,6-dichloropyrimidine(56-05-3)1HNMR2-Amino-4,6-dichloropyrimidine(56-05-3)13CNMR2-Amino-4,6-dichloropyrimidine(56-05-3)IR12-Amino-4,6-dichloropyrimidine(56-05-3)IR22-Amino-4,6-dichloropyrimidine(56-05-3)Raman

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Pyrimidine, 2-amino-4,6-dichloro- 2-AMINO-4,6-DICHLOROPYRIMIDINE, TECH. 95% 4,6-Dichloro-2-aminopyrimidine 2-Amino-4,6-dichloropyrimidine,95%,tech. 6-dichloropyriMidine 2-Amino-4,6-dichloropyrimidine,98% 4,6-Dichloropyrimidin-2-amine, 2-Amino-4,6-dichloro-1,3-diazine 2-Amino-4,6-dichL oropyrimidine TIMTEC-BB SBB003919 LABOTEST-BB LT00080771 4,6-dichloro-2-pyrimidinamine 4,6-DICHLORO-PYRIMIDIN-2-YLAMINE 2-AMINO-4,6-DICHLOROPYRIMIDINE AKOS 90013 2-PYRIMIDINAMINE, 4,6-DICHLORO- 2-amino-4,6-dichoropyrimidine 2-AMINO-4,6-DICHLOROPYRIMIDINE 95+% 2-AMINO-4,6-DICHLOROPYRIMIDINE 97+% 2-amino-4,6-dichloro-pyrimidin 4,6-dichloro-2-pyrimidinamin py11 2-AMINO-4-6-DICHLOROPYRIMIDINECRYSTALLIN E 2-Amino-4,6-dichloropyrimidine > 4,6-Dichlorpyrimidin-2-ylamin 4,6-Dichloro-2-pyrimidinamine, 97+% 56-05-3 2-Amino-4,6-dichloropyrimidine 56-05-3 4,6-DICHLOROPYRIMIDIN-2-AMINE ADCP 56-05-3 1956-05-03 1956-0'5-3 56-05-4 56-05-6 56-05-5 65-05-3 1956-05-3 C4H3N3Cl2 C4H3Cl2N3 C4HH3Cl2N3 C4H3CI2N3 Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines Heterocycle-Pyrimidine series Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks Pyrimidines Pyridines, Pyrimidines, Purines and Pteredines Pyrimidine bc0001