ChemicalBook >> CAS DataBase List >>4'-(Trifluoromethyl)propiophenone

4'-(Trifluoromethyl)propiophenone

4'-(Trifluoromethyl)propiophenone structure

CAS No.: 711-33-1

Chemical Name:: 4'-(Trifluoromethyl)propiophenone

Synonyms: p-trifluoromethylpropiophenone;4-(TRIFLUOROMETHYL)PROPIOPHENONE;4'-(Trifluoromethyl)propiophenone;4'-(Trifluoromethyl)propiophenone 97%;4'-(Trifluoromethyl)propiophenone,97%;Ethyl 4-(trifluoromethyl)phenyl ketone;p-Trifluoromethylpropiophenone, min. 97%;1-[4-(Trifluoromethyl)phenyl]-1-propanone;1-(4-(trifluoromethyl)phenyl)propan-1-one;1-Propanone, 1-[4-(trifluoromethyl)phenyl]-

CBNumber:: CB4723967

Molecular Formula:: C10H9F3O

Molecular Weight:: 202.17

MDL Number:: MFCD00039231

MOL File:: 711-33-1.mol

MSDS File:: SDS

Last updated:2026-09-12 18:52:57

Request For Quotation

4'-(Trifluoromethyl)propiophenone Properties

Melting point	36-39 °C(lit.)
Boiling point	216 °C(lit.)
Density	1,973 g/cm³
Flash point	210 °F
storage temp.	Inert atmosphere,Room Temperature
form	fused solid
color	White/colourless
BRN	1874014
InChI	1S/C10H9F3O/c1-2-9(14)7-3-5-8(6-4-7)10(11,12)13/h3-6H,2H2,1H3
InChIKey	QFKOWENRSZZLPK-UHFFFAOYSA-N
SMILES	CCC(=O)c1ccc(cc1)C(F)(F)F
CAS DataBase Reference	711-33-1(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HazardClass

IRRITANT

HS Code

29147000

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
0		0

4'-(Trifluoromethyl)propiophenone price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	T4250	1-[4-(Trifluoromethyl)phenyl]propan-1-one min. 98.0 %	711-33-1	5G	$63	2026-04-30	Buy
Apolloscientific	PC7766	4'-(Trifluoromethyl)propiophenone 97%	711-33-1	5g	$22	2026-06-04	Buy
Apolloscientific	PC7766	4'-(Trifluoromethyl)propiophenone 97%	711-33-1	25g	$101	2026-06-04	Buy
Apolloscientific	PC7766	4'-(Trifluoromethyl)propiophenone 97%	711-33-1	100g	$343	2026-06-04	Buy
Activate Scientific	AS48676	1-(4-(Trifluoromethyl)phenyl)propan-1-one 97%	711-33-1	5g	$23	2026-06-04	Buy

Product number	Packaging	Price	Buy
T4250	5G	$63	Buy
PC7766	5g	$22	Buy
PC7766	25g	$101	Buy
PC7766	100g	$343	Buy
AS48676	5g	$23	Buy

4'-(Trifluoromethyl)propiophenone Chemical Properties, Uses, Production

Chemical Properties

solid

Uses

4-(Trifluoromethyl)propiophenone is used as a reagent in the preparation of ketones and alcohols in organic synthesis. It is also used as a starting material for the synthesis of various compounds such as 4-(trifluoromethyl)phenylacetic acid, which is used as a building block in the synthesis of pharmaceuticals.

Synthesis

1-[4-(TRIFLUOROMETHYL)PHENYL]PROPAN-1-OL

67081-98-5

711-33-1

General procedure for the synthesis of 4-(trifluoromethyl)propiophenone from 1-(4-trifluoromethylphenyl)-1-propanol: First, a solution of 1-(4-trifluoromethylphenyl)-1-propanol prepared in step 1 was mixed with 3.9 kg of tetrabutylammonium hydrogensulphate and 12.3 kg of sodium dihydrogen phosphate dihydrate and dissolved in 32 L of deionized water. Subsequently, the mixture was washed with 10 L of deionized water, and then 318 kg of a 12% aqueous sodium perchlorate solution was added to the mixture, followed by washing the reaction mixture with 35 L of deionized water. The resulting solution was allowed to stand for 30 minutes before the organic layer was separated and mixed with 358 L of deionized water and 18 kg of 38% hydrochloric acid and stirred for 5 minutes. The organic layer was separated and washed with deionized water to finally obtain 378 kg of 4-(trifluoromethyl)propiophenone from the organic layer (yield: 97.2%).

References

[1] Synthetic Communications, 1989, vol. 19, # 9-10, p. 1735 - 1744
[2] Patent: WO2006/112565, 2006, A1. Location in patent: Page/Page column 16-17
[3] Journal of Medicinal Chemistry, 1995, vol. 38, # 20, p. 3918 - 3932
[4] European Journal of Medicinal Chemistry, 1995, vol. 30, # 1, p. 85 - 94
[5] Journal of Organic Chemistry, 2003, vol. 68, # 4, p. 1594 - 1596

4'-(Trifluoromethyl)propiophenone synthesis

Synthesis of 4'-(Trifluoromethyl)propiophenone from 2-Bromobenzotrifluoride and Propionic anhydride

4'-(Trifluoromethyl)propiophenone Preparation Products And Raw materials

Raw materials

Phenyl 4-(trifluoromethyl)benzoate Benzene, 1-(1-propynyl)-4-(trifluoromethyl)- Benzene, 1-(1E)-1-propen-1-yl-4-(trifluoromethyl)- Lithium, [4-(trifluoromethyl)phenyl]- 1-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol

alpha,alpha,alpha-Trifluoro-o-toluoyl chloride 1-[4-(Trifluoromethyl)phenyl]propan-1-ol 4'-(Trifluoromethyl)acetophenone 1-(4-(trifluoroMethyl)phenyl)propan-2-one N-Methoxy-N-methyl-propionamide

2-Bromobenzotrifluoride Bromoethane 4-(Trifluoromethyl)benzoic acid 4-Bromobenzotrifluoride

1of3

Preparation Products

2-Methyl-1-[4-(trifluoromethyl)phenyl]propan-1-one

4'-(Trifluoromethyl)propiophenone Suppliers

Global Suppliers ( 142)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Shanghai Harvest Chemical Industrial Co., Ltd.	15721252604 17321035817	sales@harvest-chem.com	China	2829	64
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Energy Chemical	61
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Jia Xing Isenchem Co.,Ltd	66
Shanghai Harvest Chemical Industrial Co., Ltd.	64
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Shandong Xiya Chemical Co., Ltd	57
Tianjin heowns Biochemical Technology Co., Ltd.	57

View Latest Price from 4'-(Trifluoromethyl)propiophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	4'-(TRIFLUOROMETHYL)PROPIOPHENONE 711-33-1	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2024-04-24	4'-(Trifluoromethyl)propiophenone 711-33-1	$30.00-100.00	1kg	99.93%	1000kg per week	Ouhuang Engineering Materials (Hubei) Co., Ltd
2023-08-18	4'-(TRIFLUOROMETHYL)PROPIOPHENONE 711-33-1	$50.00	1kg	99.9%	10000MT	Henan Bao Enluo International TradeCo.，LTD

4'-(TRIFLUOROMETHYL)PROPIOPHENONE
711-33-1
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

4'-(Trifluoromethyl)propiophenone
711-33-1
$30.00-100.00
99.93%
Ouhuang Engineering Materials (Hubei) Co., Ltd

4'-(TRIFLUOROMETHYL)PROPIOPHENONE
711-33-1
$50.00
99.9%
Henan Bao Enluo International TradeCo.，LTD

4'-(Trifluoromethyl)propiophenone Spectrum

4'-(TRIFLUOROMETHYL)PROPIOPHENONE(711-33-1)¹HNMR

711-33-1 (4'-(Trifluoromethyl)propiophenone) Related Search:

3'-Fluoro-4'-(trifluoromethyl)propiophenone 3'-Fluoro-5'-(trifluoromethyl)propiophenone 2'-Fluoro-3'-(trifluoromethyl)propiophenone 2'-Fluoro-4'-(trifluoromethyl)propiophenone 3',5'-Bis(trifluoromethyl)propiophenone

Lanperisone 2'-(Trifluoromethyl)propiophenone 97%,2'-(TRIFLUOROMETHYL)PROPIOPHENONE,2-(TRIFLUOROMETHYL)PROPIOPHENONE,2'-(Trifluoromethyl)propiophenone97% 3-(Trifluoromethyl)phenylacetone 2'-Fluoro-5'-(trifluoromethyl)propiophenone 2-Methoxybenzylhydrazine dihydrochloride

2-Fluoro-5-(trifluoromethyl)propiophenone, 97 3'-(Trifluoromethyl)propiophenone 4'-(Trifluoromethyl)propiophenone 4'-Fluoro-3'-(trifluoromethyl)propiophenone 1-[4-(Trifluoromethyl)phenyl]propane-1,2-dione

2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione 6-Chloro-1-oxo-1-(4-trifluoromethylphenyl)hexane 5-Chloro-1-oxo-1-(4-trifluoromethylphenyl)pentane

1of4

4'-(Trifluoromethyl)propiophenone,97% 4'-(Trifluoromethyl)propiophenone 97% 1-(4-(trifluoromethyl)phenyl)propan-1-one p-Trifluoromethylpropiophenone, min. 97% 1-[4-(Trifluoromethyl)phenyl]-1-propanone Ethyl 4-(trifluoromethyl)phenyl ketone 4-(TRIFLUOROMETHYL)PROPIOPHENONE p-trifluoromethylpropiophenone 1-Propanone, 1-[4-(trifluoromethyl)phenyl]- 1-[4-(trifluoromethyl)phenyl]propan-1-one 4'-(TRIFLUOROMETHYL)PROPIOPHENONE 4′-(Trifluoromethyl)propiophenone, CAS 711-33-1 4'-(Trifluoromethyl)propiophenone 711-33-1 Carbonyl Compounds C10 Building Blocks Ketones Organic Building Blocks KETONE C10 Carbonyl Compounds Ketones