Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Bisindolylmaleimide III

Bisindolylmaleimide III

Bisindolylmaleimide III Structure
Bisindolylmaleimide III structure
CAS No.
137592-43-9
Chemical Name:
Bisindolylmaleimide III
Synonyms
Bisindolylmaleimide III;Bisindolylmaleimide III, 10 mM in DMSO;Bisindolylmaleimide III, PKC inhibitor;3-[1-(3-aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-
CBNumber:
CB4728487
Molecular Formula:
C23H20N4O2
Molecular Weight:
384.43
MDL Number:
MFCD01076633
MOL File:
Mol file
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:57
Request For Quotation

Bisindolylmaleimide III Properties

Boiling point 708.7±60.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
solubility DMSO: soluble; Methanol: soluble
form A crystalline solid
pka 8.15±0.60(Predicted)
color Brown to reddish brown

Bisindolylmaleimide III price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 11072 Bisindolylmaleimide III ≥98% 137592-43-9 1mg $63 2026-04-30 Buy
Cayman Chemical 11072 Bisindolylmaleimide III ≥98% 137592-43-9 5mg $190 2026-04-30 Buy
Usbiological 044604 Bisindolylmaleimide III ≥98%(NMR) 137592-43-9 1mg $295 2026-06-03 Buy
Usbiological 044604 Bisindolylmaleimide III ≥98%(NMR) 137592-43-9 5mg $460 2026-06-03 Buy
ChemScene CS-0065853 Bisindolylmaleimide III 98.95% 137592-43-9 5mg $162 2026-06-04 Buy
Product number Packaging Price Buy
11072 1mg $63 Buy
11072 5mg $190 Buy
044604 1mg $295 Buy
044604 5mg $460 Buy
CS-0065853 5mg $162 Buy

Bisindolylmaleimide III Chemical Properties, Uses, Production

Description

Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine. At 1 μM, bisindolylmaleimide III inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency. Additionally, it inhibits PDK1, an important kinase in the insulin signaling pathway, with an IC50 value of 3.8 μM.

Uses

Bisindolylmaleimide III is a protein kinase C inhibitor and was also shown to exhibit inhibitory activities towards PDK1, an important kinase in the insulin signaling pathway,

Definition

ChEBI: Bisindolylmaleimide III is a member of maleimides and a member of indoles. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor. It is functionally related to a maleimide.

IC 50

PKCα

References

[1] PETER D. DAVIS. Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides[J]. Journal of Medicinal Chemistry, 1992, 35 1: 177-184. DOI: 10.1021/jm00079a024
[2] DAVID SORIANO-CASTELL  Pamela M  Antonio Currais. Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis[J]. Free Radical Biology and Medicine, 2021, 171: Pages 219-231. DOI: 10.1016/j.freeradbiomed.2021.05.023

Bisindolylmaleimide III Preparation Products And Raw materials

Raw materials

Preparation Products

Bisindolylmaleimide III Suppliers

Global Suppliers ( 42)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979 info@tsbiochem.com China 8039 58
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9787 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 sales@rrkchem.com China 57336 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Shanghai TaoSu Biochemical Technology Co., Ltd. 58
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58

View Latest Price from Bisindolylmaleimide III manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bisindolylmaleimide III pictures 2026-07-14 Bisindolylmaleimide III
137592-43-9
 $71.00-195.00 98.60% 10g TargetMol Chemicals Inc.

Bisindolylmaleimide III Spectrum

BISINDOLYLMALEIMIDE III(137592-43-9)1HNMR

137592-43-9 (Bisindolylmaleimide III) Related Search:

GF109203X Bisindolylmaleimide I hydrochloride Bisindolylmaleimide VIII acetate salt Bisindolylmaleimide V 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione
RO-31-8220

1of2

3-[1-(3-aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione 1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)- 3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione Bisindolylmaleimide III, PKC inhibitor Bisindolylmaleimide III, 10 mM in DMSO Bisindolylmaleimide III 137592-43-9 Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals