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2-CHLORO-5-FLUOROANISOLE

2-CHLORO-5-FLUOROANISOLE structure

CAS No.: 450-89-5

Chemical Name:: 2-CHLORO-5-FLUOROANISOLE

Synonyms: 2-Chloro-5-flouroanisole;2-CHLORO-5-FLUOROANISOLE;2-Chloro-5-fluoroanisole98%;2-Chloro-5-fluoroanisole >2-Chloro-5-fluoroanisole,97%;2-Chloro-5-fluoroanisole 98%;1-CHLORO-4-FLUORO-2-METHOXYBENZENE;1-Chloro-2-methoxy-4-fluorobenzene;Benzene, 1-chloro-4-fluoro-2-methoxy-;2-CHLORO-5-FLUOROANISOLE ISO 9001：2015 REACH

CBNumber:: CB4753153

Molecular Formula:: C7H6ClFO

Molecular Weight:: 160.57

MDL Number:: MFCD00042573

MOL File:: 450-89-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:15:13

Product description	Number	Pack Size	Price
2-Chloro-5-fluoroanisole >97.0%(GC)	C2216	5g	$60
2-Chloro-5-fluoroanisole >98%	PC1824E	1g	$21
2-Chloro-5-fluoroanisole >98%	PC1824E	5g	$28
2-Chloro-5-fluoroanisole >98%	PC1824E	25g	$119
2-Chloro-5-fluoroanisole >98%	PC1824E	100g	$434
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2-CHLORO-5-FLUOROANISOLE Properties

Boiling point	195 °C / 757mmHg
Density	1.28
refractive index	1.519
storage temp.	Sealed in dry,Room Temperature
form	Liquid
color	Clear colorless
CAS DataBase Reference	450-89-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H227-H315-H319

Precautionary statements

P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501

Hazard Codes

Risk Statements

10-36/37/38-36/38

Safety Statements

16-26-36-37/39-35-28-15-3/9

RIDADR

1993

Hazard Note

Irritant

HS Code

29093090

NFPA 704

	2
2		0

2-CHLORO-5-FLUOROANISOLE price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C2216	2-Chloro-5-fluoroanisole >97.0%(GC)	450-89-5	5g	$60	2026-04-30	Buy
Apolloscientific	PC1824E	2-Chloro-5-fluoroanisole >98%	450-89-5	1g	$21	2026-06-04	Buy
Apolloscientific	PC1824E	2-Chloro-5-fluoroanisole >98%	450-89-5	5g	$28	2026-06-04	Buy
Apolloscientific	PC1824E	2-Chloro-5-fluoroanisole >98%	450-89-5	25g	$119	2026-06-04	Buy
Apolloscientific	PC1824E	2-Chloro-5-fluoroanisole >98%	450-89-5	100g	$434	2026-06-04	Buy

Product number	Packaging	Price	Buy
C2216	5g	$60	Buy
PC1824E	1g	$21	Buy
PC1824E	5g	$28	Buy
PC1824E	25g	$119	Buy
PC1824E	100g	$434	Buy

2-CHLORO-5-FLUOROANISOLE Chemical Properties,Uses,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Synthesis

3827-49-4

74-88-4

450-89-5

To a solution of 2-chloro-5-fluorophenol (959 mg, 6.54 mmol) in N,N-dimethylformamide (DMF, 15 mL) was added 60% sodium hydride (NaH, 496 mg, 12.4 mmol) in batches at 0 °C. After the hydrogen bubbling stopped, iodomethane (0.43 mL, 6.91 mmol) was added and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was slowly poured into a beaker containing water and crushed ice, alkalized with saturated aqueous sodium bicarbonate (NaHCO3) and extracted with dichloromethane (DCM). The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using hexane:ethyl acetate (9:1) as eluent to afford 1-chloro-4-fluoro-2-methoxybenzene (600 mg) as a colorless oil. High performance liquid chromatography (HPLC, 254 nm) retention time (Rt): 6.15 min. 1H nuclear magnetic resonance (NMR, 600 MHz, DMSO-d6) δ ppm: 3.86 (s, 3H), 6.76-6.85 (m, 1H), 7.10 (dd, J = 10.90, 2.84 Hz, 1H), 7.45 (dd, J = 8.70, 6.14 Hz, 1H).

References

[1] Patent: WO2017/220477, 2017, A1. Location in patent: Page/Page column 33

2-CHLORO-5-FLUOROANISOLE Preparation Products And Raw materials

Raw materials

2-Chloro-5-fluorophenol Iodomethane Sodium hydride N,N-Dimethylformamide

Preparation Products

4-Fluoro-2-methoxyphenol

2-CHLORO-5-FLUOROANISOLE Suppliers

Global( 128)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14304	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Changzhou Ansciep Chemical Co., Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
career henan chemical co	58
Fuxin Pharmaceutical	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58

View Lastest Price from 2-CHLORO-5-FLUOROANISOLE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-10	2-CHLORO-5-FLUOROANISOLE 450-89-5	$1.00	1KG	99%	100KG	Career Henan Chemical Co

2-CHLORO-5-FLUOROANISOLE
450-89-5
$1.00
99%
Career Henan Chemical Co

2-CHLORO-5-FLUOROANISOLE Spectrum

2-CHLORO-5-FLUOROANISOLE(450-89-5)¹HNMR

450-89-5(2-CHLORO-5-FLUOROANISOLE)Related Search:

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1-CHLORO-4-FLUORO-2-METHOXYBENZENE 2-CHLORO-5-FLUOROANISOLE 2-Chloro-5-fluoroanisole 98% 2-Chloro-5-fluoroanisole98% 1-Chloro-2-methoxy-4-fluorobenzene 2-Chloro-5-fluoroanisole,97% 2-Chloro-5-fluoroanisole1-Chloro-4-fluoro-2-methoxybenzene 2-Chloro-5-flouroanisole 1-Chloro-4-fluoro-2-methoxybenzene, 2-Chloro-5-fluorophenyl methyl ether 2-Chloro-5-fluoroanisole > Benzene, 1-chloro-4-fluoro-2-methoxy- 2-CHLORO-5-FLUOROANISOLE ISO 9001：2015 REACH 450-89-5 Anisole Anisoles, Alkyloxy Compounds & Phenylacetates Chlorine Compounds Fluorine Compounds