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4-Chloro-3-fluoroanisole

4-Chloro-3-fluoroanisole Structure
4-Chloro-3-fluoroanisole structure
CAS No.
501-29-1
Chemical Name:
4-Chloro-3-fluoroanisole
Synonyms
1-CHLORO-2-FLUORO-4-METHOXYBENZENE;4-Chloro-3-fluoroanisole;3-Fluoro-4-chloroanisole;4-Chloro-3-fluoroanisole98%;4-Chloro-3-fluoroanisole,97%;4-Chloro-3-fluoroanisole 98%;4-Chloro-3-fluoroanisole >chloro-2-fluoro-4-methoxybenzene;Benzene, 1-chloro-2-fluoro-4-Methoxy-;4-CHLORO-3-FLUOROANISOLE ISO 9001：2015 REACH
CBNumber:
CB9181841
Molecular Formula:
C7H6ClFO
Molecular Weight:
160.57
MDL Number:
MFCD00042570
MOL File:
501-29-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:56:12
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4-Chloro-3-fluoroanisole Properties

Boiling point 200-204°C
Density 1.26
refractive index 1.516-1.518
Flash point 60.8±21.8℃
storage temp. Sealed in dry,Room Temperature
form clear liquid
color Colorless to Light yellow
CAS DataBase Reference 501-29-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H227
Precautionary statements  P210-P280-P403+P235-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26
RIDADR  1993
Hazard Note  Irritant
HS Code  2909309090
NFPA 704
0
1 0

4-Chloro-3-fluoroanisole price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C1273 4-Chloro-3-fluoroanisole >95.0%(GC) 501-29-1 5g $77 2024-03-01 Buy
Apolloscientific PC1824J 4-Chloro-3-fluoroanisole 98% 501-29-1 5g $21 2026-06-04 Buy
Apolloscientific PC1824J 4-Chloro-3-fluoroanisole 98% 501-29-1 25g $52 2026-06-04 Buy
Apolloscientific PC1824J 4-Chloro-3-fluoroanisole 98% 501-29-1 100g $204 2026-06-04 Buy
Activate Scientific AS26298 4-Chloro-3-fluoroanisole 95% 501-29-1 5g $30 2026-06-04 Buy
Product number Packaging Price Buy
C1273 5g $77 Buy
PC1824J 5g $21 Buy
PC1824J 25g $52 Buy
PC1824J 100g $204 Buy
AS26298 5g $30 Buy

4-Chloro-3-fluoroanisole Chemical Properties, Uses, Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Synthesis

4-Chloro-3-fluorophenol

348-60-7

Iodomethane

74-88-4

4-CHLORO-3-FLUOROANISOLE

501-29-1

To a solution of acetone (10 mL) containing 4-chloro-3-fluorophenol (500 mg, 3.41 mmol) was added potassium carbonate (942.59 mg, 6.82 mmol) and iodomethane (1.94 g, 13.64 mmol). The reaction mixture was stirred at 60 °C for 16 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether:ethyl acetate = 20:1) to confirm the completion of the reaction. After completion of the reaction, the mixture was concentrated to remove the solvent. Water (20 mL) was added to the residue and extracted with ethyl acetate (20 mL x 3). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 4-chloro-3-fluoroanisole (470 mg, 2.93 mmol, 85.84% yield) as a colorless oil.

References

[1] Patent: CN105330698, 2016, A. Location in patent: Paragraph 0593; 0594; 0595; 0596
[2] Patent: WO2011/56652, 2011, A1. Location in patent: Page/Page column 118-119

4-Chloro-3-fluoroanisole Preparation Products And Raw materials

Raw materials

4-Chloro-3-fluorophenol Iodomethane Potassium carbonate Acetone

Preparation Products

1-Chloro-2-fluoro-3-iodo-4-methoxybenzene

4-Chloro-3-fluoroanisole Suppliers

Global Suppliers ( 135)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
J & K SCIENTIFIC LTD. 76
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Jia Xing Isenchem Co.,Ltd 66
Adamas Reagent, Ltd. 59
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64

View Latest Price from 4-Chloro-3-fluoroanisole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-3-fluoroanisole pictures 2022-02-19 4-Chloro-3-fluoroanisole
501-29-1
 1KG 97.0% 100 tons Honest Joy Holdings Limited
4-CHLORO-3-FLUOROANISOLE pictures 2020-02-17 4-CHLORO-3-FLUOROANISOLE
501-29-1
 $1.00 1KG 98% HPLC 10 tons Career Henan Chemical Co

4-Chloro-3-fluoroanisole Spectrum

4-CHLORO-3-FLUOROANISOLE(501-29-1)1HNMR4-CHLORO-3-FLUOROANISOLE(501-29-1)FT-IR

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Benzene, 1-chloro-2-fluoro-4-Methoxy- 4-Chloro-3-fluoroanisole 98% 4-Chloro-3-fluoroanisole98% 3-Fluoro-4-chloroanisole 4-Chloro-3-fluoroanisole,97% chloro-2-fluoro-4-methoxybenzene 4-Chloro-3-fluoroanisole > 4-CHLORO-3-FLUOROANISOLE ISO 9001：2015 REACH 1-CHLORO-2-FLUORO-4-METHOXYBENZENE 4-Chloro-3-fluoroanisole 501-29-1 Anisole Anisoles, Alkyloxy Compounds & Phenylacetates Chlorine Compounds Fluorine Compounds