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1,4-Dihydroxynaphthalene

1,4-Dihydroxynaphthalene Structure
1,4-Dihydroxynaphthalene structure
CAS No.
571-60-8
Chemical Name:
1,4-Dihydroxynaphthalene
Synonyms
NAPHTHALENE-1,4-DIOL;1,4-NAPHTHALENEDIOL;1,4-NDO;1.4-Dihydroxyn;1,4-naphthoquinol;1,4-NAPTHALENEDIOL;Hydronaphthoquinone;Naphthohydroquinone;Naphthalin-1,4-diol;1,4-Naphththalenediol
CBNumber:
CB4756341
Molecular Formula:
C10H8O2
Molecular Weight:
160.17
MDL Number:
MFCD00003977
MOL File:
571-60-8.mol
MSDS File:
SDS
Last updated:2026-07-16 07:06:08
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1,4-Dihydroxynaphthalene Properties

Melting point 191-192 °C (dec.)
Boiling point 246.06°C (rough estimate)
Density 1.0924 (rough estimate)
refractive index 1.5178 (estimate)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
pka pK1:9.37;pK2:10.93 (26°C，μ=0.65)
form crystals
color Grey
Water Solubility slightly soluble
BRN 1307689
InChI 1S/C10H8O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6,11-12H
InChIKey PCILLCXFKWDRMK-UHFFFAOYSA-N
SMILES Oc1ccc(O)c2ccccc12
CAS DataBase Reference 571-60-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII AML1P6T42C
NIST Chemistry Reference 1,4-Naphthalenediol(571-60-8)
EPA Substance Registry System 1,4-Naphthalenediol (571-60-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335-H412
Precautionary statements  P261-P273-P280-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,T
Risk Statements  22-37/38-41-43-36/37/38-25
Safety Statements  26-39-45-36/37/39-28A-24
WGK Germany  3
RTECS  QJ4730000
F  8-10-16-23
TSCA  TSCA listed
HS Code  2921450090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Aquatic Chronic 3
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

1,4-Dihydroxynaphthalene price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 70430 1,4-Dihydroxynaphthalene technical, ≥90% (HPLC) 571-60-8 10g $172 2026-04-30 Buy
TCI Chemical D0589 1,4-Dihydroxynaphthalene >97.0%(GC)(T) 571-60-8 5g $117 2026-04-30 Buy
TCI Chemical D0589 1,4-Dihydroxynaphthalene >97.0%(GC)(T) 571-60-8 25g $353 2026-04-30 Buy
ChemScene CS-0197295 Naphthohydroquinone ≥98% 571-60-8 5g $35 2026-06-04 Buy
ChemScene CS-0197295 Naphthohydroquinone ≥98% 571-60-8 25g $78 2026-06-04 Buy
Product number Packaging Price Buy
70430 10g $172 Buy
D0589 5g $117 Buy
D0589 25g $353 Buy
CS-0197295 5g $35 Buy
CS-0197295 25g $78 Buy

1,4-Dihydroxynaphthalene Chemical Properties, Uses, Production

Chemical Properties

brown to greyish powder. 1,4-Naphthalenediol [571-60-8], mp 195℃, is synthesized by reduction of 1,4- naphthoquinone with sodium dithionite, or by hydrolysis of 4-amino-1-naphthol with 20 % sulfuric acid. It undergoes oxidation to give 1,4-naphthoquinone; amination to give 4-amino-1-naphthol; and methylation (MeOH – HCl) to give 4-methoxy-1-naphthol.

Uses

1,4-Dihydroxynaphthalene is frequently used in organic synthesis as a reagent. In particular, it is used in the synthesis of a pH independent and cell permeant fluorescent dye, a hydroxyl regioisomeric 3'',4''-benzorhodol, which can be used as a fluorescent chemosensor and biomarker for biological applications.

Definition

ChEBI: Naphthalene-1,4-diol is a naphthalenediol and a naphthohydroquinone.

Biological Activity

1,4-Dihydroxynaphthalene is a potent HSV-1 protease inhibitor with inhibitory effects on the HCMV protease, which can be used to study herpesviruses.

References

[1] LAURIE S. TSURUDA   A. D J  Michael W Lamé. Formation of epoxide and quinone protein adducts in B6C3F1 mice treated with naphthalene, sulfate conjugate of 1,4-dihydroxynaphthalene and 1,4-naphthoquinone[J]. Archives of Toxicology, 1995, 69 6: 362-367. DOI:10.1007/s002040050185.

1,4-Dihydroxynaphthalene synthesis

107-96-0
130-15-4
571-60-8
65726-66-1
Synthesis of 1,4-Dihydroxynaphthalene from 3-Mercaptopropionic acid and 1,4-Naphthoquinone

1,4-Dihydroxynaphthalene Preparation Products And Raw materials

Raw materials

5,6,11,12,17,18-Trinaphthylenehexone 1,4-Naphthalenediol, 1-acetate trans-1-methoxy-1,3-butadiene Propanoic acid,3-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)thio]- Dodecyl aldehyde
1,4-Diacetoxynaphthalene 2-Amino-3-chloro-1,4-naphthoquinone 1,4-Benzoquinone Butyraldehyde Naphthalene
1-Naphthol 3,4-Dihydro-2H-pyran 1-Tetralone

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Preparation Products

2-Chloro-1,4-naphthoquinone 4-Methoxy-1-naphthol 2,3-Dihydro-1,4-naphthoquinone

1,4-Dihydroxynaphthalene Suppliers

Global Suppliers ( 195)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Sphinx Scientific Laboratory (Tianjin) Co., Ltd. 022-66211289-843 13672102692 contact@sphinxpharm.com China 361 62
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28364 80
TCI Europe 320-37350700 sales@tcieurope.eu Europe 23654 75
Supplier Advantage
J & K SCIENTIFIC LTD. 76
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shandong Xiya Chemical Co., Ltd 57
Syntechem Co.,Ltd 57
Sphinx Scientific Laboratory (Tianjin) Co., Ltd. 62
T&W GROUP 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
TOKYO CHEMICAL INDUSTRY CO., LTD. 80
TCI Europe 75

View Latest Price from 1,4-Dihydroxynaphthalene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,4-Dihydroxynaphthalene pictures 2026-09-02 1,4-Dihydroxynaphthalene
571-60-8
 $2.00-10.00 1KG 99% Henan Fengda Chemical Co., Ltd
1,4-Dihydroxynaphthalene pictures 2026-07-16 1,4-Dihydroxynaphthalene
571-60-8
 $31.00 97.10% 10g TargetMol Chemicals Inc.
1,4-Dihydroxynaphthalene pictures 2020-01-01 1,4-Dihydroxynaphthalene
571-60-8
 $1.00 1KG 95-99% 1ton Career Henan Chemical Co

1,4-Dihydroxynaphthalene Spectrum

1,4-Dihydroxynaphthalene(571-60-8)MS1,4-Dihydroxynaphthalene(571-60-8)1HNMR1,4-Dihydroxynaphthalene(571-60-8)13CNMR1,4-Dihydroxynaphthalene(571-60-8)IR11,4-Dihydroxynaphthalene(571-60-8)IR2

571-60-8 (1,4-Dihydroxynaphthalene) Related Search:

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1,4-NAPHTHOHYDROQUINONE 1,4-NAPTHALENEDIOL P-NAPHTHOHYDROQUINONE 1,4-DIHYDROXYNAPHTHALENE 1,4-NDO 1,4-NAPHTHALENEDIOL 1,4-Dihydroxynaphthalene, 95+% ALPHA-NAPHTHOHYDROQUINONE 1,4-dihydroxynaphthalene,1:1mixturewith1,4-naphthoquinone 1,4-naphthoquinol 1,4-Naphththalenediol alpha-naphthoquinhydrone Hydronaphthoquinone Naphthalenediol-(1,4) Naphthohydroquinone 1,4-DIHYDROXYNAPTHALENE 1,4-Naphthalenediol, p-Naphthohydroquinone (α) 1,4-Dihydroxynaphthalene, balance mainly 1,4-Naphthoquinone,92% 1,4-Dihydroxynaphthalene, balance mainly 1,4-Naphthoquinone, 92% Naphthalene-1,4-diol, 95%+ 1,4-Naphthalenediol alpha-Naphthohydroquinone 1.4-Dihydroxyn 1,4-Dihydroxynaphthalene, technical 1,4-Dihydroxynaphthalene > Naphthalin-1,4-diol Bifeprunox Impurity 10 1,4-Dihydroxynaphthalene (Naphthalene-1,4-diol) NAPHTHALENE-1,4-DIOL 571-60-8 132-86-6 Oxygen Compounds Polyols Organic Building Blocks Building Blocks Naphthalene derivatives Intermediates of Dyes and Pigments