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Clozapine N-oxide

Clozapine N-oxide Structure
Clozapine N-oxide structure
CAS No.
34233-69-7
Chemical Name:
Clozapine N-oxide
Synonyms
Clozapine N-oxide;Clozapine Impurity 16;Clozapine N-Oxide imp;Clozapine N-oxide (CNO);CNO (Clozapine N-oxide);Clozapine N-oxide[C0832];Clozapine N-oxide solution;CLOZAPINE N-OXIDE, 10 mM in DMSO;Clozapine N-oxide Methanol Adduct;Clozapine N-oxide dihydrochloride NEW
CBNumber:
CB4759216
Molecular Formula:
C18H19ClN4O
Molecular Weight:
342.82
MDL Number:
MFCD00210190
MOL File:
34233-69-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:57
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Clozapine N-oxide Properties

Melting point 190-248°C
Flash point 9℃
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility Soluble in DMSO.
form powder
pka 6.86±0.20(Predicted)
color Yellow
biological source synthetic
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI InChI=1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChIKey OGUCZBIQSYYWEF-UHFFFAOYSA-N
SMILES N1=C(N2CC[N+]([O-])(C)CC2)C2=CC=CC=C2NC2=CC=C(Cl)C=C12
FDA UNII MZA8BK588J
UNSPSC Code 12352119
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301-H336
Precautionary statements  P301+P310+P330
target organs Central nervous system
Hazard Codes  Xn,T,F
Risk Statements  22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements  26-36-45-36/37-16-7
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  HP1760000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29335990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
STOT SE 3
NFPA 704
0
4 0

Clozapine N-oxide price More Price(75)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C0832 Clozapine N-oxide 34233-69-7 5mg $257 2026-04-30 Buy
TCI Chemical C3891 Clozapine N-Oxide 34233-69-7 25MG $426 2025-07-31 Buy
Cayman Chemical 16882 Clozapine N-oxide ≥98% 34233-69-7 1mg $43 2026-04-30 Buy
Cayman Chemical 16882 Clozapine N-oxide ≥98% 34233-69-7 5mg $86 2026-04-30 Buy
Cayman Chemical 16882 Clozapine N-oxide ≥98% 34233-69-7 10mg $151 2026-04-30 Buy
Product number Packaging Price Buy
C0832 5mg $257 Buy
C3891 25MG $426 Buy
16882 1mg $43 Buy
16882 5mg $86 Buy
16882 10mg $151 Buy

Clozapine N-oxide Chemical Properties, Uses, Production

Description

Clozapine-N-oxide (34233-69-7) is a clozapinemetabolite1which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2May be used to control grafted human pluripotent stem cell-derived neurons engineered to express DREADDs.3,4Numerous other applications.5,6

Chemical Properties

Yellow Solid

Uses

Clozapine N-oxide has been used:

  • for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
  • for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
  • in behavioral testing in mice and for stimulating (HEK293) cells

Uses

A 5-HT2 antagonist. A major metabolite of clozapine that can be monitored by HPLC. Possesses little or no activity towards serotonin receptors

Definition

ChEBI: Clozapine N-oxide is a dibenzodiazepine.

General Description

Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.

Biochem/physiol Actions

5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.

storage

Room temperature (desiccate)

References

[1] BIRGIT EIERMANN. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine[J]. British journal of clinical pharmacology, 2003, 44 5: 439-446. DOI:10.1046/j.1365-2125.1997.t01-1-00605.x
[2] BLAINE N ARMBRUSTER. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2007: 5163-5168. DOI:10.1073/pnas.0700293104
[3] YUEJUN CHEN. Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease.[J]. Cell stem cell, 2016, 18 6: 817-826. DOI:10.1016/j.stem.2016.03.014
[4] ELENA M VAZEY  Gary A J. Designer receptors: therapeutic adjuncts to cell replacement therapy in Parkinson’s disease.[J]. Journal of Clinical Investigation, 2014, 124 7: 2858-2860. DOI:10.1172/jci76833
[5] JUAN L. GOMEZ. Chemogenetics revealed: DREADD occupancy and activation via converted clozapine[J]. Science, 2017, 357 6350. DOI:10.1126/science.aan2475
[6] CATHERINE A. MARCINKIEWCZ. Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala[J]. Nature, 2016, 537 7618: 97-101. DOI:10.1038/nature19318

Clozapine N-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

Clozapine N-oxide Suppliers

Global Suppliers ( 229)
Supplier Tel Email Country ProdList Advantage
Shanghai Zhuyan Biotechnology Co., Ltd. 17521259211 17521259211@163.com China 136 58
Beijing Yisiyan Technology Research Center 010-56645598 13366904824; bjkaida@163.com China 1596 59
Shanghai Fine Biotech Co.，Ltd 18221172427; 18221172427 sale@fine-biotech.com China 227 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
ShangHai YuanYe Biotechnology Co., Ltd. 15026964105 shyysw007@163.com China 4998 60
Supplier Advantage
Shanghai Zhuyan Biotechnology Co., Ltd. 58
Beijing Yisiyan Technology Research Center 59
Shanghai Fine Biotech Co.，Ltd 58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chembest Research Laboratories Limited 61
Adamas Reagent, Ltd. 59
Chemsky（shanghai）International Co.,Ltd. 50
Dalian Meilun Biotech Co., Ltd. 58
ShangHai YuanYe Biotechnology Co., Ltd. 60

View Latest Price from Clozapine N-oxide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Clozapine N-Oxide pictures 2026-07-27 Clozapine N-Oxide
34233-69-7
 $30.00-76.00 99.65% 10g TargetMol Chemicals Inc.
Clozapine N-oxide pictures 2021-07-13 Clozapine N-oxide
34233-69-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
Clozapine N-oxide pictures 2021-07-09 Clozapine N-oxide
34233-69-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • Clozapine N-oxide pictures
  • Clozapine N-oxide
    34233-69-7
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Clozapine N-oxide pictures
  • Clozapine N-oxide
    34233-69-7
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Clozapine N-oxide Spectrum

CLOZAPINE N-OXIDE(34233-69-7)1HNMR

34233-69-7 (Clozapine N-oxide) Related Search:

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1of4

e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(n-oxide 8-CHLORO-11-[4-METHYL-1-PIPERAZINYL]-5H-DIBENZO[B,E][1,4]DIAZEPINE N-OXIDE MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS Clozapine N-oxide Methanol Adduct Clozapine N-oxide solution Clozapine N-oxide (CNO) 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine Clozapine impurity 5/Clozapine N-Oxide/4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide Clozapine N-oxide dihydrochloride NEW Clozapine N-Oxide (1.0 mg/mL in Methanol) Clozapine N-oxide (4-oxido-piprazinyl) 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)- Clozapine N-OxideQ: What is Clozapine N-Oxide Q: What is the CAS Number of Clozapine N-Oxide Q: What is the storage condition of Clozapine N-Oxide Q: What are the applications of Clozapine N-Oxide Clozapine Impurity 16 3-Chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine Clozapine N-Oxide imp 4-(8-Chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide Clozapine N-oxide (4-oxido-piprazinyl) in methanol Clozapine N-oxide, Metabolite of Clozapine (aqueous solution) Clozapine N-oxide, Metabolite of Clozapine CLOZAPINE N-OXIDE, 10 mM in DMSO CNO (Clozapine N-oxide) Clozapine N-oxide[C0832] Clozapine N-oxide 34233-69-7 C18H19ClN4O2HCl C18H19ClN4O Various Metabolites and Impurities Metabolites